2021
Sex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III
Verplaetse TL, Peltier MR, Roberts W, Burke C, Moore KE, Pittman B, McKee SA. Sex and alcohol use disorder predict the presence of cancer, respiratory, and other medical conditions: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Addictive Behaviors 2021, 123: 107055. PMID: 34311184, PMCID: PMC8419091, DOI: 10.1016/j.addbeh.2021.107055.Peer-Reviewed Original ResearchConceptsSignificant medical conditionsMedical conditionsNational Epidemiologic SurveyDSM-5 AUDRespiratory conditionsEpidemiologic SurveyAlcohol useU.S. National Epidemiologic SurveyRate of drinkingPresence of cancerAlcohol use disorderRelated Conditions-IIIHeavy alcohol useGreater health consequencesYears cancerProblematic alcohol useUse disordersOrgan systemsCancerHealth consequencesRelated conditionsEffective interventionsWomenConditions-IIISexSex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders
Peltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology 2021, 187: 108499. PMID: 33600842, PMCID: PMC7992136, DOI: 10.1016/j.neuropharm.2021.108499.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStress-related disordersAlcohol useMajor depressive disorderAlcohol-related disordersAlcohol use disorderPosttraumatic stress disorderStress regulation systemComplex comorbiditiesDepressive disorderProblematic alcohol useUse disordersAlcohol misuseTherapeutic potentialTrauma exposureSubstance abuseStress disorderAnxiety disordersDisordersExposure resultsProgestogensNeurosteroidsNegative affectWomenComorbiditiesMale counterparts
2020
A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States
Roberts W, Marotta PL, Verplaetse TL, Peltier MR, Burke C, Ramchandani VA, McKee SA. A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States. Drug And Alcohol Dependence 2020, 216: 108210. PMID: 32805549, PMCID: PMC7609495, DOI: 10.1016/j.drugalcdep.2020.108210.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioRisk factorsAlcohol useTobacco usersNicotine metabolismTrans-3'-HydroxycotinineWave 1Biochemical risk factorsAlcohol consumption amountCurrent tobacco usersNicotine metabolism rateAssociated health outcomesSex differencesAlcohol use outcomesCigarette smokersNicotine exposureProspective studyOdds ratioTobacco useDrinking statusHealth StudyAlcohol consumptionNicotine useMetabolite ratiosHealth outcomesChanges in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation
Peltier MR, Verplaetse TL, Roberts W, Moore K, Burke C, Marotta PL, Phillips S, Smith PH, McKee SA. Changes in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation. Biology Of Sex Differences 2020, 11: 37. PMID: 32665024, PMCID: PMC7362573, DOI: 10.1186/s13293-020-00314-7.Peer-Reviewed Original ResearchConceptsMenopausal transitionExcessive alcohol useExcessive drinkingAlcohol useRandom effects logistic regressionAlcohol-related health consequencesSuch health problemsMethodsThe present studyPresent studyConclusionsThe present studyMenopausal transition stageSex-specific factorsHigher testosterone levelsBackgroundRecent dataEstradiol levelsPostmenopausal stageSex hormonesTestosterone levelsHormonal changesOlder womenAlcoholism criteriaAlcohol abuseAlcohol consumptionWomen's healthStudy of womenSex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years
Verplaetse TL, Cosgrove KP, Tanabe J, McKee SA. Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years. Journal Of Neuroscience Research 2020, 99: 309-323. PMID: 32333417, PMCID: PMC7584757, DOI: 10.1002/jnr.24625.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol consumptionNarrative reviewBrain functionAlcohol useRisk of AUDMagnetic resonance imagingPositron emission tomographyDiffusion tensor imagingHigh-risk drinkingFunctional magnetic resonanceImaging outcomesSex/genderProblematic alcohol consumptionUse disordersResonance imagingEmission tomographySex/gender differencesRobust increaseTensor imagingBrain imaging researchRecent neuroimaging literatureWomenEvent-related potentialsNeurobiological underpinningsProspective association of e‐cigarette and cigarette use with alcohol use in two waves of the Population Assessment of Tobacco and Health
Roberts W, Verplaetse T, Peltier MKR, Moore KE, Gueorguieva R, McKee SA. Prospective association of e‐cigarette and cigarette use with alcohol use in two waves of the Population Assessment of Tobacco and Health. Addiction 2020, 115: 1571-1579. PMID: 31977106, PMCID: PMC7340560, DOI: 10.1111/add.14980.Peer-Reviewed Original ResearchConceptsAlcohol use outcomesHazardous alcohol useE-cigarette useE-cigarettesCigarette useAlcohol useUse outcomesExposure groupCigarette usersTotal drinksSocio-demographic risk factorsUnited States adult populationWave 1Non-institutionalized adultsStates adult populationHarmful alcohol consumptionNon-daily useE-cigarette usersPoorer alcohol use outcomesSocio-demographic characteristicsRisk factorsHealth SurveyHigher oddsTobacco cigarettesAlcohol abuse
2019
Sex differences in stress-related alcohol use
Peltier MR, Verplaetse TL, Mineur YS, Petrakis IL, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in stress-related alcohol use. Neurobiology Of Stress 2019, 10: 100149. PMID: 30949562, PMCID: PMC6430711, DOI: 10.1016/j.ynstr.2019.100149.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAlcohol use disorderAlcohol useSex differencesAlcohol-induced neurodegenerationStress reactivityPresent narrative reviewAlcohol-related health consequencesEarly life stressBrain stress systemsOvarian hormonesPsychiatric comorbidityStress-related drinkingProblematic alcohol useUse disordersNarrative reviewBrain regionsBehavioral treatmentHealth consequencesStress systemAvailable evidenceRole of stressAlcohol addictionWomenLife stressExamination of sex
2018
Electronic Cigarette Use and Risk of Harmful Alcohol Consumption in the U.S. Population
Roberts W, Moore K, Peltier MR, Verplaetse TL, Oberleitner L, Hacker R, McKee SA. Electronic Cigarette Use and Risk of Harmful Alcohol Consumption in the U.S. Population. Alcohol Clinical And Experimental Research 2018, 42: 2385-2393. PMID: 30222189, PMCID: PMC6286236, DOI: 10.1111/acer.13889.Peer-Reviewed Original ResearchConceptsAlcohol use disorderE-cigarette useHarmful alcohol useE-cigarette usersHarmful alcohol consumptionAlcohol use outcomesElectronic cigarette useCigarette useAlcohol useE-cigarettesUse outcomesNondaily usersUse disordersAlcohol consumptionPast-year e-cigarette useHazardous drinkingAssociated Disabilities Interview ScheduleCigarette/e-cigarette useU.S. populationRelated Conditions Wave IIIDrinking frequencyTobacco cigarette useNational Epidemiologic SurveyBinge drinking frequencyQuantity/frequencyTobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking
Roberts W, Ralevski E, Verplaetse TL, McKee SA, Petrakis IL. Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. Journal Of Substance Use And Addiction Treatment 2018, 94: 91-96. PMID: 30243424, PMCID: PMC6154389, DOI: 10.1016/j.jsat.2018.08.015.Peer-Reviewed Original ResearchConceptsAlcohol use disorderClinical trialsSmoking outcomesNicotinic acetylcholine receptor antagonistAlcohol useHigh-dependence smokersEffects of mecamylamineSubgroups of smokersAcetylcholine receptor antagonistHigh tobacco dependencePlacebo groupMedication conditionReceptor antagonistMedication effectsTobacco dependenceTobacco useTreatment respondersMecamylamineSmokingTreatment phaseUse disordersAlcohol dependenceSmokersTrialsSignificant differences
2017
Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms
Roberts W, Verplaetse TL, Moore K, Oberleitner L, Picciotto MR, McKee SA. Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms. Journal Of Psychopharmacology 2017, 31: 906-914. PMID: 28351203, PMCID: PMC5823265, DOI: 10.1177/0269881117699618.Peer-Reviewed Original ResearchConceptsDepressive symptomsAlcohol cravingAlcohol useEffects of vareniclineRole of nAChRsHuman laboratory studiesDSM-IV criteriaSymptoms of depressionAlcohol use disorderLaboratory testing sessionsMore depressive symptomsMedication pretreatmentPlasma levelsPriming doseVareniclineUse disordersTreatment moderatorsAlcohol consumptionDepression symptomsHeavy drinkersAlcohol usersDrinking taskSymptomsLess drinkingDrinkers