2024
PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury
Kauer S, Benson C, Carrara J, Tarafder A, Ibrahim Y, Estacion M, Waxman S, Tan A. PAK1 inhibition with Romidepsin attenuates H‐reflex hyperexcitability after spinal cord injury. The Journal Of Physiology 2024, 602: 5061-5081. PMID: 39231098, DOI: 10.1113/jp284976.Peer-Reviewed Original ResearchDendritic spine dysgenesisSpinal cord injurySCI-induced spasticityRomidepsin treatmentSpine dysgenesisLoss of rate-dependent depressionCutaneous T-cell lymphomaTreatment of cutaneous T-cell lymphomaContusive spinal cord injuryT-cell lymphomaSpinal cord injury animalsCord injuryRate-dependent depressionExaggerated reflex responsesH-reflex changesSpinal cord injury mouse modelManaging spasticityReduce spasticityReporter micePreclinical utilityDrug responseRomidepsinControl cohortIntervention effectsSpinal hyperreflexia
2023
Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury
Benson C, Olson K, Patwa S, Kauer S, King J, Waxman S, Tan A. Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury. Journal Of Neuroscience 2023, 44: e1670222023. PMID: 37963762, PMCID: PMC10851682, DOI: 10.1523/jneurosci.1670-22.2023.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRate-dependent depressionΑ-motor neuronsGlutamate transporter 1Dendritic spine dysgenesisCord injurySpine dysgenesisDevelopment of SCIMild contusion spinal cord injuryAstrocytic glutamate transporter 1Glial-specific glutamate transporterContusion spinal cord injuryTransporter 1Development of hyperreflexiaMonosynaptic H-reflexDendritic spine densityPre-injury levelSpinal reflex circuitsVentral spinal cordReflex hyperexcitabilityHyperexcitability disordersFunctional recoveryGlutamate clearanceH-reflexVentral hornIncreased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia
Benson C, King J, Kauer S, Waxman S, Tan A. Increased astrocytic GLT-1 expression in tripartite synapses is associated with SCI-induced hyperreflexia. Journal Of Neurophysiology 2023, 130: 1358-1366. PMID: 37877184, PMCID: PMC10972632, DOI: 10.1152/jn.00234.2023.Peer-Reviewed Original ResearchConceptsSpinal cord injuryRate-dependent depressionTripartite synapsesGLT-1Astrocytic GLT-1 expressionChronic neurological complicationsGLT-1 expressionAstrocyte involvementChronic spasticityUninjured shamsNeurological complicationsNeuropathic painHyperexcitability disordersH-reflexPSD-95 proteinReactive astrocytesVentral hornCord injuryMuscle toneAstrocytes' roleSpinal cordSpinal circuitsSynaptic transmissionHyperreflexiaSpasticity
2008
Alarm or curse? The pain of neuroinflammation
Saab C, Waxman S, Hains B. Alarm or curse? The pain of neuroinflammation. Brain Research Reviews 2008, 58: 226-235. PMID: 18486228, DOI: 10.1016/j.brainresrev.2008.04.002.Peer-Reviewed Original ResearchConceptsImmune cellsExperimental spinal cord injuryContribution of microgliaNociceptive nervous systemPeripheral nerve injuryExposure of neuronsSpinal cord injuryDevelopment of pharmacotherapiesNeuropathic injuryNeuropathic painNerve injuryPainful behaviorChronic painNeuroexcitatory effectsCord injuryChronic activationNervous systemPainImmune systemInjuryIdentification of moleculesNeuronsFunctional consequencesCellsDetrimental consequencesLocomotor Dysfunction and Pain: The Scylla and Charybdis of Fiber Sprouting After Spinal Cord Injury
Deumens R, Joosten E, Waxman S, Hains B. Locomotor Dysfunction and Pain: The Scylla and Charybdis of Fiber Sprouting After Spinal Cord Injury. Molecular Neurobiology 2008, 37: 52-63. PMID: 18415034, DOI: 10.1007/s12035-008-8016-1.Peer-Reviewed Original ResearchConceptsChronic painFiber sproutingAutonomic dysreflexiaMotor functionDorsal horn laminaePrimary afferent fibersSpinal cord injuryInterruption of connectionsDevelopment of therapiesMotor deficitsMotor dysfunctionNociceptive processingSensory fibersAfferent fibersCord injuryMotor fibersAberrant sproutingRegenerative sproutingSpinal cordLocomotor dysfunctionInhibitory barrierPainAxonal growthFiber tractsDysreflexia
2006
Fire and phantoms after spinal cord injury: Na+ channels and central pain
Waxman S, Hains B. Fire and phantoms after spinal cord injury: Na+ channels and central pain. Trends In Neurosciences 2006, 29: 207-215. PMID: 16494954, DOI: 10.1016/j.tins.2006.02.003.Peer-Reviewed Original ResearchConceptsSpinal cord injuryNeuropathic painCord injurySpinal cord dorsal horn neuronsDorsal horn neuronsNervous system injuryCentral painPain pathwaysSystem injuryThalamic neuronsPainAbnormal expressionPhantom phenomenaNeuronsInjuryMolecular targetsMolecular changesRecent findingsHyperexcitabilityNav1.3Molecular basis
2003
Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury
Hains B, Black J, Waxman S. Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. The Journal Of Comparative Neurology 2003, 462: 328-341. PMID: 12794736, DOI: 10.1002/cne.10733.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCortical motor neuronsFluoro-GoldCorticospinal tractCord injuryMotor neuronsTerminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphateAdult male Sprague-Dawley ratsRetrograde tracer Fluoro-GoldMale Sprague-Dawley ratsApoptotic cell deathDorsal corticospinal tractPrimary motor cortexTracer Fluoro-GoldSprague-Dawley ratsVoluntary motor controlTUNEL-positive cellsCell deathEvidence of apoptosisSham surgeryDorsal funiculusMotor cortexPyramidal cellsLesion sitePositive cells
2002
Primary motor neurons fail to up‐regulate voltage‐gated sodium channel Nav1.3/brain type III following axotomy resulting from spinal cord injury
Hains B, Black J, Waxman S. Primary motor neurons fail to up‐regulate voltage‐gated sodium channel Nav1.3/brain type III following axotomy resulting from spinal cord injury. Journal Of Neuroscience Research 2002, 70: 546-552. PMID: 12404508, DOI: 10.1002/jnr.10402.Peer-Reviewed Original ResearchConceptsSpinal cord injuryUpper motor neuronsPrimary motor cortexDorsal root gangliaMotor neuronsCord injuryMotor cortexRat primary motor cortexDorsal column transectionIpsilateral DRG neuronsCortical motor neuronsSciatic nerve transectionTraumatic head injuryFacial motor neuronsSodium channel expressionPrimary motor neuronsVoltage-gated sodium channelsPeripheral axotomyDRG neuronsNerve transectionLayer VControl brainsHead injuryRoot gangliaSpinal cord
2000
Experimental Approaches to Restoration of Function of Ascending and Descending Axons in Spinal Cord Injury
Waxman S, Kocsis J. Experimental Approaches to Restoration of Function of Ascending and Descending Axons in Spinal Cord Injury. Contemporary Neuroscience 2000, 215-239. DOI: 10.1007/978-1-59259-200-5_10.Peer-Reviewed Original ResearchSpinal cord injuryRestoration of functionCord injuryDemyelinated spinal cord axonsSpinal cord traumaResult of demyelinationSpinal cord axonsSubpopulation of axonsNormal action potentialCord traumaResidual axonsAxonal conductionSpinal cordConduction blockDescending axonsSCI researchAction potentialsAxonsDemyelinationInjurySignificant factor
1997
Spinal Cord Repair: Progress Towards a Daunting Goal
Waxman S, Kocsis J. Spinal Cord Repair: Progress Towards a Daunting Goal. The Neuroscientist 1997, 3: 263-269. DOI: 10.1177/107385849700300414.Peer-Reviewed Original ResearchSpinal cord repairSpinal cordHuman spinal cord injuryUse of neurotrophinsSpinal cord injuryMyelin-forming glial cellsSpinal cord tractsFunctional recoveryNerve graftsAnatomical repairCord injuryGlial cellsAnimal modelsWhite matterGray matterClinical goalsCordInjuryPartial restorationRepairDaunting goalTransplantationNeurotrophinsGraftCNS
1991
Non-synaptic mechanisms of Ca2+-mediated injury in CNS white matter
Waxman S, Ransom B, Stys P. Non-synaptic mechanisms of Ca2+-mediated injury in CNS white matter. Trends In Neurosciences 1991, 14: 461-468. PMID: 1722366, DOI: 10.1016/0166-2236(91)90046-w.Peer-Reviewed Original Research
1989
Demyelination in spinal cord injury
Waxman S. Demyelination in spinal cord injury. Journal Of The Neurological Sciences 1989, 91: 1-14. PMID: 2664092, DOI: 10.1016/0022-510x(89)90072-5.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryDemyelinated axonsFunctional recoveryCompressive spinal cord injuryAbsence of remyelinationRecovery of conductionRecovery of functionSmall-diameter axonsModification of conductionHemorrhagic necrosisPathophysiological basisClinical criteriaComplete transectionSchwann cellsDemyelinationDiameter axonsAction potentialsInjuryDemyelinated fibersAxonsRemyelinationNeurophysiological evidencePhysiological studiesTransection