2024
TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization
Gualdani R, Barbeau S, Yuan J, Jacobs D, Gailly P, Dib-Hajj S, Waxman S. TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406186121. PMID: 39226353, PMCID: PMC11406256, DOI: 10.1073/pnas.2406186121.Peer-Reviewed Original ResearchConceptsLaser-assisted in situ keratomileusisPhotorefractive keratectomyOcular Surface Disease Index scoreCapsaicin-induced desensitizationPhotorefractive keratectomy enhancementDisease Index scorePhysiological membrane potentialsCorneal neuralgiaTRPV1 variantsCorneal painRefractive surgeryRefractive errorCapsaicin desensitizationPersistent painBradykinin sensitivityNerve injuryM mutationPatch clampChannel activitySurgical techniqueLeftward shiftInflammatory mediatorsM-channelPainIndex score
2011
Sodium channels and microglial function
Black JA, Waxman SG. Sodium channels and microglial function. Experimental Neurology 2011, 234: 302-315. PMID: 21985863, DOI: 10.1016/j.expneurol.2011.09.030.Peer-Reviewed Original ResearchConceptsCentral nervous systemSodium channel isoformsEffector functionsChannel isoformsMultiple cytokines/chemokinesResident immune cellsResponse of microgliaCytokines/chemokinesVoltage-gated sodium channel isoformsSpinal cord parenchymaSodium channel activityMicroglial functionPromotion of repairCord parenchymaImmune cellsMicrogliaNervous systemCell surface receptorsContinuous surveillanceAdhesion moleculesSodium channelsActivating signalsChannel activitySignaling pathwaysSurface receptors