Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands
Liosi ME, Ippolito JA, Henry SP, Krimmer SG, Newton AS, Cutrona KJ, Olivarez RA, Mohanty J, Schlessinger J, Jorgensen WL. Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. Journal Of Medicinal Chemistry 2022, 65: 8380-8400. PMID: 35653642, PMCID: PMC9939005, DOI: 10.1021/acs.jmedchem.2c00283.Peer-Reviewed Original ResearchHumansJanus Kinase 2Janus KinasesLigandsMutationMyeloproliferative DisordersSignal TransductionSTAT Transcription Factors