Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity
Jastreboff AM, Lacadie C, Seo D, Kubat J, Van Name MA, Giannini C, Savoye M, Constable RT, Sherwin RS, Caprio S, Sinha R. Leptin Is Associated With Exaggerated Brain Reward and Emotion Responses to Food Images in Adolescent Obesity. Diabetes Care 2014, 37: 3061-3068. PMID: 25139883, PMCID: PMC4207200, DOI: 10.2337/dc14-0525.Peer-Reviewed Original ResearchConceptsLow-calorie foodsBrain responsesFood imagesEmotion processingEmotion responsesAdolescent brainNeural responsesNeural activationHigh-calorie food consumptionFood cravingsNeural alterationsBrain rewardFunctional MRIAdolescent obesityRisk of overconsumptionAdolescentsObesity-related metabolic changesEndogenous leptin levelsFood advertisingMetabolic changesYouthDevelopment of obesityType 2 diabetesLean adolescentsNation's youthA low disposition index in adolescent offspring of mothers with gestational diabetes: a risk marker for the development of impaired glucose tolerance in youth
Holder T, Giannini C, Santoro N, Pierpont B, Shaw M, Duran E, Caprio S, Weiss R. A low disposition index in adolescent offspring of mothers with gestational diabetes: a risk marker for the development of impaired glucose tolerance in youth. Diabetologia 2014, 57: 2413-2420. PMID: 25168408, DOI: 10.1007/s00125-014-3345-2.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusImpaired glucose toleranceType 2 diabetesGlucose toleranceNGDM groupDisposition indexInsulin sensitivityNormal glucose toleranceLower disposition indexOral disposition indexBeta-cell functionGestational diabetesDiabetes mellitusUtero exposureObese adolescentsRisk markersGlucose exposureBeta cellsDiabetesAdolescent offspringCell functionSignificant predictorsUteroEarlier inabilityExposure