2022
RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice.
Joshi AA, Wu Y, Deng S, Preston-Hurlburt P, Forbes JM, Herold KC. RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice. Clinical Immunology 2022, 245: 109165. PMID: 36257528, DOI: 10.1016/j.clim.2022.109165.Peer-Reviewed Original ResearchConceptsXenograft rejectionIL-17AHumanized miceIL-1βT cellsImmune responseRAGE antagonistsAdaptive human immune responsesPD-1 expressionSkin graft rejectionHuman immune cell responsesImmune cell responsesHuman immune responseHuman immune cellsInnate immune responseAdvanced glycation endproductsInhibition of pathwaysSmall molecule antagonistsMultiple inflammatory processesAZ therapyRAGE antagonismGraft rejectionIL-23Serum levelsMedian time
2017
β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice
Rui J, Deng S, Arazi A, Perdigoto AL, Liu Z, Herold KC. β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice. Cell Metabolism 2017, 25: 727-738. PMID: 28190773, PMCID: PMC5342930, DOI: 10.1016/j.cmet.2017.01.005.Peer-Reviewed Original ResearchConceptsΒ-cellsImmune attackNon-obese diabetic (NOD) miceImmune inhibitory markersProgression of T1DChronic autoimmune diseaseType 1 diabetesLong-term survivalNormal β-cellsHuman β-cellsIslet infiltratesAutoimmune diabetesNOD miceDiabetic miceAutoimmune diseasesInhibitory markersImmune cellsImmune responseDiabetesStemness genesΒ cell identity genesSimilar changesCell deathDiseaseMice
2014
CD45 ligation expands Tregs by promoting interactions with DCs
Camirand G, Wang Y, Lu Y, Wan YY, Lin Y, Deng S, Guz G, Perkins DL, Finn PW, Farber DL, Flavell RA, Shlomchik WD, Lakkis FG, Rudd CE, Rothstein DM. CD45 ligation expands Tregs by promoting interactions with DCs. Journal Of Clinical Investigation 2014, 124: 4603-4613. PMID: 25202978, PMCID: PMC4191025, DOI: 10.1172/jci74087.Peer-Reviewed Original ResearchConceptsT cellsTreg proliferationTreg expansionVivo expansionRegulatory T cellsConventional T cellsTransfer of TregsActivated T cellsTreg numbersTreg populationImmune toleranceHomeostatic proliferationWT miceExogenous antigensPeripheral homeostasisTregsImmune responseTherapeutic useCD45 ligationNuclear factorIntegrin-dependent mannerNuclear translocationLigationAntigenProliferationHumanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy
Vudattu NK, Waldron-Lynch F, Truman LA, Deng S, Preston-Hurlburt P, Torres R, Raycroft MT, Mamula MJ, Herold KC. Humanized Mice as a Model for Aberrant Responses in Human T Cell Immunotherapy. The Journal Of Immunology 2014, 193: 587-596. PMID: 24943216, PMCID: PMC4123131, DOI: 10.4049/jimmunol.1302455.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAutoimmune DiseasesCytokinesDisease Models, AnimalFlow CytometryHumansInterleukin Receptor Common gamma SubunitIpilimumabLiverLymphocyte ActivationMacrophagesMiceMice, Inbred NODMice, KnockoutMice, SCIDPhosphorylationSTAT5 Transcription FactorStem Cell TransplantationSurvival AnalysisT-LymphocytesT-Lymphocytes, RegulatoryTransplantation, HeterologousWeight LossConceptsAnti-nuclear AbsAutoimmune diseasesRegulatory cellsHumanized miceT cellsImmune responseWeight lossMesenteric lymph nodesHuman autoimmune diseasesInduction of autoimmunityT-cell immunotherapyRelease of IFNHuman immune responseImmune-deficient miceIpilimumab treatmentInflammatory sequelaeLymph nodesCell immunotherapyIP-10Macrophage infiltrationCytokine productionSpleen cellsPathologic processesHepatitisMice
2005
Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells
Nasr IW, Wang Y, Gao G, Deng S, Diggs L, Rothstein DM, Tellides G, Lakkis FG, Dai Z. Testicular Immune Privilege Promotes Transplantation Tolerance by Altering the Balance between Memory and Regulatory T Cells. The Journal Of Immunology 2005, 174: 6161-6168. PMID: 15879112, DOI: 10.4049/jimmunol.174.10.6161.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BlockingApoptosisCD40 AntigensCD40 LigandCD8-Positive T-LymphocytesEpitopes, T-LymphocyteGraft RejectionGrowth InhibitorsImmunologic MemoryIslets of Langerhans TransplantationLymphocyte ActivationLymphocyte CountMaleMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Interleukin-2T-Lymphocytes, RegulatoryTestisTransplantation ToleranceTransplantation, HeterotopicConceptsRegulatory T cellsNon-privileged sitesIslet allograftsTransplantation toleranceT cellsImmune privilegeCD40/CD40L costimulationIntratesticular islet allograftsIslet allograft toleranceAcute allograft rejectionProlong allograft survivalLate allograft failureTesticular immune privilegePrivileged siteAllograft failureAllograft survivalAllograft toleranceCostimulatory blockadeAllograft rejectionAlloimmune responseSkin allograftsIslet transplantationImmune regulationImmune responseAllografts