2017
β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice
Rui J, Deng S, Arazi A, Perdigoto AL, Liu Z, Herold KC. β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice. Cell Metabolism 2017, 25: 727-738. PMID: 28190773, PMCID: PMC5342930, DOI: 10.1016/j.cmet.2017.01.005.Peer-Reviewed Original ResearchConceptsΒ-cellsImmune attackNon-obese diabetic (NOD) miceImmune inhibitory markersProgression of T1DChronic autoimmune diseaseType 1 diabetesLong-term survivalNormal β-cellsHuman β-cellsIslet infiltratesAutoimmune diabetesNOD miceDiabetic miceAutoimmune diseasesInhibitory markersImmune cellsImmune responseDiabetesStemness genesΒ cell identity genesSimilar changesCell deathDiseaseMice
2005
Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue
Dai Z, Nasr IW, Reel M, Deng S, Diggs L, Larsen CP, Rothstein DM, Lakkis FG. Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue. The Journal Of Immunology 2005, 174: 1165-1170. PMID: 15661869, DOI: 10.4049/jimmunol.174.3.1165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCD8-Positive T-LymphocytesCell MovementEpitopes, T-LymphocyteFas ReceptorGraft RejectionImmunologic MemoryIslets of Langerhans TransplantationKi-1 AntigenKidneyMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutMice, Mutant StrainsMice, TransgenicTestisTransplantation, HeterotopicConceptsMemory T cellsCD8 memory T cellsT cellsForeign AgsPrivileged tissuesT cell-mediated rejectionCell-mediated rejectionPancreatic islet allograftsDelayed graft rejectionTNFR family membersPrivileged siteIntratesticular graftsGraft rejectionIslet allograftsImmunosuppressive mechanismsImmune privilegeAllogeneic graftsDiabetic miceKidney capsuleSame AgTumor cellsGraftImpaired recallFamily membersCells