Sinan Guloksuz, MD, PhD
About
Research
Publications
2024
The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier
Drukker M, Todor T, Bongaarts J, Broggi E, Kelkar M, Wigglesworth T, Verhiel K, van Leeuwen K, Koster M, Derom C, Thiery E, De Hert M, Menne-Lothmann C, Decoster J, Collip D, van Winkel R, Jacobs N, Guloksuz S, Rutten B, van Os J. The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier. BMC Psychiatry 2024, 24: 736. PMID: 39462331, PMCID: PMC11515186, DOI: 10.1186/s12888-024-06176-2.Peer-Reviewed Original ResearchConceptsAberrant salienceGeneral population twinsPsychotic experiencesGenetic vulnerabilityGeneral population samplePsychotic symptomsAssociated with psychotic experiencesUltra-high-risk patientsPositive symptom scalesSubclinical psychotic symptomsWhite noise taskEpisode psychosis patientsAssociated with psychosisPopulation samplePsychosis spectrumPsychosis patientsSymptom ScaleNoise taskSaliencePsychosisSevere endVulnerabilitySymptomsTaskAssociationClassification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts
Visoki E, Moore T, Zhang X, Tran K, Ly C, Gataviņš M, DiDomenico G, Brogan L, Fein J, Warrier V, Guloksuz S, Barzilay R. Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts. JAMA Psychiatry 2024, 81: 1020-1029. PMID: 39018056, PMCID: PMC11255979, DOI: 10.1001/jamapsychiatry.2024.1887.Peer-Reviewed Original ResearchMillennium Cohort StudyExposome scoreLifestyle factorsAdolescent Brain Cognitive DevelopmentCohort studyExposome-wide association studyAssociated with suicide attemptsUK Millennium Cohort StudyNational longitudinal cohortSuicide attemptsProtective exposuresLogistic regression modelsFamily history of suicideRisk classificationAdolescent Brain Cognitive Development StudyUS hospitalsEnvironmental/lifestyle factorsEmergency departmentTest associationsHistory of suicidePopulation settingCause of deathUS adolescentsFamily historyLongitudinal cohortCharacterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter
Malamud J, Guloksuz S, van Winkel R, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Rutten B, Huys Q. Characterizing the dynamics, reactivity and controllability of moods in depression with a Kalman filter. PLOS Computational Biology 2024, 20: e1012457. PMID: 39312537, PMCID: PMC11449358, DOI: 10.1371/journal.pcbi.1012457.Peer-Reviewed Original ResearchConceptsEcological momentary assessmentEcological momentary assessment dataMood statesMood disordersDepressive stateMood dynamicsFeatures of mood disordersCombination of ecological momentary assessmentsControl of moodSymptoms of depressionInternal emotional statesAlterations to interactionsPsychopathological featuresMomentary assessmentMoodEmotional statesDepressionEnvironmental stimuliAssociations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences
Ku B, Yuan Q, Arias-Magnasco A, Lin B, Walker E, Druss B, Ren J, van Os J, Guloksuz S. Associations Between Genetic Risk, Physical Activities, and Distressing Psychotic-like Experiences. Schizophrenia Bulletin 2024, sbae141. PMID: 39171674, DOI: 10.1093/schbul/sbae141.Peer-Reviewed Original ResearchPhysical activityPRS-SCZDistressing psychotic-like experiencesPsychotic-like experiencesDevelopment of psychosisMechanisms of physical activityGenetic liabilityParticipants of European ancestryPolygenic risk scoresIncome-to-needs ratioBody mass indexAssociated with trajectoriesAssociated with less riskAdolescent Brain Cognitive Development StudyAssociated with impaired functionFamily history of psychosisLinear mixed modelsGeneralized linear mixed modelsCognitive Development StudyHistory of psychosisEuropean ancestryGenetic riskFamily historyMass indexRisk scoreThe European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment
Schoretsanitis G, Correll C, Agorastos A, Sanchez A, Erzin G, Grigoras R, Benussi M, Gondek T, Guloksuz S, Højlund M, Jerotic S, Kilic O, Metaj E, Sidhu D, Skandali N, Skuhareuski A, Tveito M, Wolthusen R, Communication and Publications E, Chumakov E, de Filippis R. The European psychiatric association (EPA) – early career psychiatrists committee survey on trainees’ and early-career psychiatrists’ attitudes towards therapeutic drug monitoring (TDM) use and utility during antipsychotic treatment. The World Journal Of Biological Psychiatry 2024, 25: 342-351. PMID: 38905131, DOI: 10.1080/15622975.2024.2367138.Peer-Reviewed Original ResearchConceptsEuropean Psychiatric AssociationAntipsychotic treatmentPsychiatrists' attitudesTherapeutic drug monitoringEarly-career psychiatristsExploratory factor analysisBenefit of therapeutic drug monitoringPsychiatric AssociationAntipsychoticsNegative expectationsAssociated with frequencyTDM useDrug monitoringTherapeutic drug monitoring useFactor analysisBeliefs of patientsHigh-income countriesLow-/middle-income countriesResponse varianceClinical benefitClozapineOutpatient settingLinear regression analysisClinical settingPsychiatristsThe relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study.
Üçok A, Noyan H, Gülöksüz S, Saka M, Alptekin K, Atbaşoğlu C, Akturan E, Karadayı G, Baran Tatar Z, Akdede B, Binbay T, Altınyazar V, Ulaş H, Yalınçetin B, Gümüş-Akay G, Cihan B, Soygür H, Şahin Cankurtaran E, Ulusoy Kaymak S, Rutten B, van Os J. The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study. Psychological Medicine 2024, 54: 2414-2425. PMID: 38606591, DOI: 10.1017/s0033291724000540.Peer-Reviewed Original ResearchNegative cognitive schemasChildhood traumaCognitive schemasPsychotic symptomsEU-GEIEmotional abuseBrief Core Schema ScalesEU-GEI studySubthreshold psychotic experiencesSubtypes of traumaChildhood emotional abuseChildhood Trauma QuestionnaireNon-clinical populationsHealthy controlsNegative schemasPositive symptomsPersecutory delusionsPsychotic experiencesSchema ScaleTrauma QuestionnaireChildhood abuseSymptom severitySchizophreniaSexual abuseAbuseThe why and the how of transdiagnostic clinical research in youth psychiatry
Díaz-Caneja C, Guloksuz S. The why and the how of transdiagnostic clinical research in youth psychiatry. European Neuropsychopharmacology 2024, 82: 55-56. PMID: 38490086, DOI: 10.1016/j.euroneuro.2024.02.012.Peer-Reviewed Original ResearchCorrection: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. Correction: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1567-1567. PMID: 38351175, DOI: 10.1038/s41380-024-02481-0.Peer-Reviewed Original ResearchOn the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1361-1381. PMID: 38302562, DOI: 10.1038/s41380-024-02415-w.Peer-Reviewed Original ResearchSources of heterogeneitySystematic reviewProportion of patientsMeta-analysisSubgroup analysisCochrane Database of Systematic ReviewsDatabase of Systematic ReviewsMeta-analysis of studies of patientsPsychosis onsetProspective cohort studyCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsAPA PsycInfoNarrative synthesisMeta-analysis estimatesCochrane Central RegisterPrevention of psychosisAscertainment methodsWeb of Science Core CollectionRecall biasQualitative studyAssess heterogeneityCohort studyOvid MEDLINEPopulation Salutogenesis—The Future of Psychiatry?
van Os J, Guloksuz S. Population Salutogenesis—The Future of Psychiatry? JAMA Psychiatry 2024, 81: 115-116. PMID: 38117509, DOI: 10.1001/jamapsychiatry.2023.4582.Peer-Reviewed Original Research