Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation
Lowthert L, Leffert J, Lin A, Umlauf S, Maloney K, Muralidharan A, Lorberg B, Mane S, Zhao H, Sinha R, Bhagwagar Z, Beech R. Increased ratio of anti-apoptotic to pro-apoptotic Bcl2 gene-family members in lithium-responders one month after treatment initiation. Biology Of Mood & Anxiety Disorders 2012, 2: 15. PMID: 22967286, PMCID: PMC3448519, DOI: 10.1186/2045-5380-2-15.Peer-Reviewed Original ResearchBCL2-antagonist/killer 1Insulin receptor substrate 2Pathway analysisBCL2 gene family membersGene family membersRegulation of apoptosisGene expression profilesPro-apoptotic genesAnti-apoptotic genesClinical responseBipolar disorderBlood gene expression profilesLevel of expressionMolecular basisTranscript probesExpression profilesGeneGo MetaCore softwareMetaCore softwarePeripheral blood gene expression profilesCell deathSubstrate 2GenesOpen-label treatmentGold standard medicationDifferential response