2022
Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH)
Tuan JJ, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao M, Salahuddin S, Gupta S, Sutton R, Friedland G, Emu B, Ogbuagu O. Long-term quantitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV (PWH). BMC Infectious Diseases 2022, 22: 744. PMID: 36131232, PMCID: PMC9491266, DOI: 10.1186/s12879-022-07737-0.Peer-Reviewed Original ResearchConceptsT cell responsesAnti-spike IgGVisit 3SARS-CoV-2Older PWHVisit 2Immune responseSingle-center longitudinal observational studyVirus-specific T cell responsesVaccine-induced humoral immunityLong-term protective immunityT cell immune responsesOlder peopleMedian age 61RBD IgG levelsPrimary study outcomeCOVID-19 vaccinationImmune response evaluationLongitudinal observational studyCOVID-19 vaccineWilcoxon signed-rank testBNT162b2 boosterBNT162b2 vaccinationCD8 responsesDetectable CD4Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population
Zhao M, Slotkin R, Sheth AH, Pischel L, Kyriakides TC, Emu B, McNamara C, Shi Q, Delgobbo J, Xu J, Marhoffer E, Mercer-Falkoff A, Holleck J, Ardito D, Sutton RE, Gupta S. Serum Neutralizing Antibody Titers 12 Months After Coronavirus Disease 2019 Messenger RNA Vaccination: Correlation to Clinical Variables in an Adult, US Population. Clinical Infectious Diseases 2022, 76: e391-e399. PMID: 35639598, PMCID: PMC9278145, DOI: 10.1093/cid/ciac416.Peer-Reviewed Original ResearchConceptsMonth postboosterRNA vaccinationClinical variablesNeutralization responseEnd-stage renal diseaseBooster dose responsePrimary series vaccinationPrimary vaccine seriesMultiple clinical factorsSystemic steroid useDoses of vaccinePrior COVID-19Maximal inhibitory concentration valuesHalf maximal inhibitory concentration (IC50) valuesSeries vaccinationVaccine seriesVaccine regimensClinical factorsDiabetes mellitusRenal diseaseComorbid conditionsSteroid useCOVID infectionImmune responseUS populationDevelopment of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2
Ssenyange G, Kerfoot M, Zhao M, Farhadian S, Chen S, Peng L, Ren P, Dela Cruz CS, Gupta S, Sutton RE. Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2. Cell Reports Methods 2022, 2: 100252. PMID: 35757815, PMCID: PMC9213030, DOI: 10.1016/j.crmeth.2022.100252.Peer-Reviewed Original ResearchConceptsAnti-spike monoclonal antibodiesTransmission assaysTherapeutic antiviral drugsSARS-CoV-2Quantitative readoutVirus-cell bindingRapid quantificationConvalescent seraNeutralization assaysAntiviral drugsResearch reagentsSmall molecule drugsClinical settingViral replicationPseudotyped particlesMonoclonal antibodiesLaboratory equipmentQuantitative assayClinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states
Lee M, Cosentino D, Kyriakides TC, Cavallaro T, Stack G, Gupta S. Clinical and virologic factors associated with outcomes of COVID‐19 before and after vaccination among Veterans: Retrospective analysis from six New England states. Journal Of Hospital Medicine 2022, 17: 534-538. PMID: 35661577, PMCID: PMC9348310, DOI: 10.1002/jhm.12852.Peer-Reviewed Original ResearchConceptsCOVID-19Intensive care unit admissionVeterans Administration Healthcare SystemCare unit admissionNonpsychiatric hospitalizationsVirologic factorsFull vaccinationUnit admissionICU careClinical outcomesPoor outcomeMean ageRetrospective analysisD614G mutationHealthcare systemVeteransNew England statesHospitalizationOlder cohortOutcomesViral epidemiologyVaccinationDemographic factorsG mutationAgePancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites
Ilagan-Ying YC, Park EY, Lam R, Gupta S. Pancreatic Neuroendocrine Tumor Presenting with Chylous Ascites: Multidisciplinary Workup to Differentiate from Malignant Ascites. Journal Of General Internal Medicine 2022, 37: 2082-2085. PMID: 35260958, PMCID: PMC9198176, DOI: 10.1007/s11606-022-07463-y.Peer-Reviewed Case Reports and Technical Notes
2020
Advances in rapid diagnostics for bloodstream infections
Briggs N, Campbell S, Gupta S. Advances in rapid diagnostics for bloodstream infections. Diagnostic Microbiology And Infectious Disease 2020, 99: 115219. PMID: 33059201, DOI: 10.1016/j.diagmicrobio.2020.115219.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSARS-CoV-2 detection in setting of viral swabs scarcity: Are MRSA swabs and viral swabs equivalent?
Federman DG, Gupta S, Stack G, Campbell SM, Peaper DR, Dembry LM, Fisher A, Tarabar AF, Kozal M, Ruser CB. SARS-CoV-2 detection in setting of viral swabs scarcity: Are MRSA swabs and viral swabs equivalent? PLOS ONE 2020, 15: e0237127. PMID: 32756602, PMCID: PMC7406068, DOI: 10.1371/journal.pone.0237127.Peer-Reviewed Original ResearchConceptsMRSA swabsViral swabSARS-CoV-2 PCR testingCopan ESwabSevere acute respiratory syndromeMRSA nasal swabSARS-CoV-2 assayAcute respiratory syndromeCOVID-19SARS-CoV-2SARS-CoV-2 detectionNasopharyngeal swabsCoronavirus 2Nasal swabsRespiratory syndromePCR testingSwab collectionSwabsSwab samplesCepheid Xpert XpressXpert XpressWidespread testingCollection kitHealthcare systemViral mediaHospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System
Gupta S, Federman DG. Hospital preparedness for COVID-19 pandemic: experience from department of medicine at Veterans Affairs Connecticut Healthcare System. Postgraduate Medicine 2020, 132: 489-494. PMID: 32331509, PMCID: PMC7212542, DOI: 10.1080/00325481.2020.1761668.Peer-Reviewed Original ResearchConceptsVeterans Affairs Connecticut Healthcare SystemPandemic coronavirus disease 2019Healthcare systemCoronavirus disease 2019Department of MedicineSurge of patientsMore patientsHealthcare workersDisease 2019Hospital preparednessEpidemiologic predictionsPandemic preparednessHospital systemCOVID-19PatientsCOVID-19 pandemicPandemicHospitalPreparednessCare
2019
Stethoscope hygiene: Using cultures and real-time feedback with bioluminescence-based adenosine triphosphate technology to change behavior
Holleck JL, Campbell S, Alrawili H, Frank C, Merchant N, Rodwin B, Perez MF, Gupta S, Federman DG, Chang JJ, Vientos W, Dembry L. Stethoscope hygiene: Using cultures and real-time feedback with bioluminescence-based adenosine triphosphate technology to change behavior. American Journal Of Infection Control 2019, 48: 380-385. PMID: 31761292, DOI: 10.1016/j.ajic.2019.10.005.Peer-Reviewed Original ResearchNative Joint Septic Arthritis: Comparison of Outcomes with Medical and Surgical Management.
Harada K, McConnell I, DeRycke EC, Holleck JL, Gupta S. Native Joint Septic Arthritis: Comparison of Outcomes with Medical and Surgical Management. Southern Medical Journal 2019, 112: 238-243. PMID: 30943544, DOI: 10.14423/smj.0000000000000958.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnkle JointAnti-Bacterial AgentsArthritis, InfectiousArthrocentesisArthroscopyCandidiasisDrainageElbow JointFemaleGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsHip JointHospitalizationHumansKnee JointMaleMiddle AgedRange of Motion, ArticularRecovery of FunctionRetrospective StudiesShoulder JointStaphylococcal InfectionsSternoclavicular JointStreptococcal InfectionsTertiary Care CentersWrist JointConceptsSeptic arthritisSurgical managementCases of SADiagnosis of SARetrospective single-center studyNative joint septic arthritisSingle-center studyTertiary care hospitalLong-term outcomesLength of stayShort-term rehabilitationComparison of outcomesNative joint infectionsCare hospitalMedical managementJoint infectionRehabilitation unitInclusion criteriaEvaluated outcomesNative jointProsthetic jointsFull recoveryPatientsOutcomesSame joint
2018
Menace Elbow: Disseminated Nocardiosis
Datta R, Kramer E, Reinhart H, Campbell S, Wong E, Gupta S. Menace Elbow: Disseminated Nocardiosis. The American Journal Of Medicine 2018, 131: 1307-1309. PMID: 29729234, PMCID: PMC6482376, DOI: 10.1016/j.amjmed.2018.04.012.Peer-Reviewed Case Reports and Technical Notes
2017
The “Hand-in” Project
Holleck JL, Gunderson CG, Antony SM, Gupta S, Chang JJ, Merchant N, Lin S, Federman DG. The “Hand-in” Project. Southern Medical Journal 2017, 110: 694-698. PMID: 29100218, DOI: 10.14423/smj.0000000000000724.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmbulatory CareComputer SecurityContinuity of Patient CareElectronic MailEmergency Service, HospitalFemaleHospitalistsHospitalizationHumansInterprofessional RelationsMalePatient ReadmissionPhysicians, Primary CareProspective StudiesUnited StatesUnited States Department of Veterans AffairsCan education influence stethoscope hygiene?
Holleck JL, Merchant N, Lin S, Gupta S. Can education influence stethoscope hygiene? American Journal Of Infection Control 2017, 45: 811-812. PMID: 28668135, DOI: 10.1016/j.ajic.2017.02.004.Peer-Reviewed Original Research
2016
Diagnostic accuracy of methicillin-resistant Staphylococcus aureus nasal colonization to predict methicillin-resistant S aureus soft tissue infections
Gunderson CG, Holleck JL, Chang JJ, Merchant N, Lin S, Gupta S. Diagnostic accuracy of methicillin-resistant Staphylococcus aureus nasal colonization to predict methicillin-resistant S aureus soft tissue infections. American Journal Of Infection Control 2016, 44: 1176-1177. PMID: 27311510, DOI: 10.1016/j.ajic.2016.03.039.Peer-Reviewed Original ResearchConceptsSoft tissue infectionsMRSA infectionTissue infectionsPrevalence populationsMethicillin-resistant Staphylococcus aureus nasal colonizationMRSA soft tissue infectionsStaphylococcus aureus nasal colonizationHigh-prevalence populationsLow-prevalence populationsPositive likelihood ratioNegative likelihood ratioNasal MRSALikelihood ratioNasal colonizationClinical utilityInfectionDiagnostic accuracyAdmissionHospitalPopulationMRSAPrevalenceClinical characteristics and outcomes of veterans hospitalised with purulent soft tissue infections with and without systemic signs of infection
Gunderson CG, Holleck J, Chang JJ, Lin S, Merchant N, Gupta S. Clinical characteristics and outcomes of veterans hospitalised with purulent soft tissue infections with and without systemic signs of infection. Infectious Diseases 2016, 48: 503-508. PMID: 26950290, DOI: 10.3109/23744235.2016.1154599.Peer-Reviewed Original ResearchConceptsPurulent soft tissue infectionsSoft tissue infectionsTissue infectionsClinical characteristicsSevere sepsisSIRS groupSystemic signsSIR groupSystemic inflammatory response syndrome criteriaBroad Gram-negative activityMethods Retrospective cohort studyOutcomes of veteransAcute kidney injuryRetrospective cohort studyEpisodes of bacteremiaTime of hospitalisationCohort of patientsMajority of patientsMost clinical characteristicsUse of antibioticsMore bacteremiaKidney injuryShorter hospitalisationSyndrome criteriaCohort studyParvimonas micra: A rare cause of native joint septic arthritis
Baghban A, Gupta S. Parvimonas micra: A rare cause of native joint septic arthritis. Anaerobe 2016, 39: 26-27. PMID: 26911898, DOI: 10.1016/j.anaerobe.2016.02.004.Peer-Reviewed Case Reports and Technical NotesConceptsNative joint septic arthritisSeptic arthritisCases of discitisKnee septic arthritisSignificant joint destructionFrequent boneHematogenous seedingJoint destructionSubacute presentationRare causeDental proceduresPeriodontal diseaseParvimonas micraPeptostreptococcus microsGastrointestinal floraProsthetic jointsPositive cocciArthritisJoint pathogensOrganism identificationRRNA sequencingMicraAssociationLiterature reviewDiscitis
2014
Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects
Gupta S, Lataillade M, Kyriakides TC, Chiarella J, St. John EP, Webb S, Moreno EA, Simen BB, Kozal MJ. Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects. Viruses 2014, 6: 3428-3437. PMID: 25256391, PMCID: PMC4189030, DOI: 10.3390/v6093428.Peer-Reviewed Original ResearchConceptsNNRTI resistance mutationsMajor NNRTI-resistance mutationsResistance mutationsAntiretroviral-naïve subjectsARV-naïve HIVMajor NNRTI mutationsNNRTI-resistant variantsTreatment-naïve HIVHIV-1 variantsNon-nucleoside reverseMutational loadNaïve HIVNNRTI mutationsNNRTI resistanceVariant frequencyTrue burdenTherapeutic failureTreatment outcomesTreatment responseAa positionsHIVViral variantsFurther evaluationResistant variantsDeep sequencingDeep Sequencing of HIV: Clinical and Research Applications
Chabria SB, Gupta S, Kozal MJ. Deep Sequencing of HIV: Clinical and Research Applications. Annual Review Of Genomics And Human Genetics 2014, 15: 1-31. PMID: 24821496, DOI: 10.1146/annurev-genom-091212-153406.BooksConceptsHuman immunodeficiency virusAntiretroviral therapyDrug-resistant human immunodeficiency virusDrug-resistant HIV variantsCare antiretroviral therapyMaximal viral suppressionTreatment-naive individualsDrug resistance mutationsViral quasispeciesViral suppressionDrug selective pressureAntiretroviral agentsSensitive genotyping methodsTreatment failureHIV transmissionImmunodeficiency virusHIV variantsClinical careVaccine developmentViral variantsViral heterogeneityMolecular virologyLow-frequency variantsViral fitnessSequencing-based assays
2009
Raltegravir With Unboosted Atazanavir 300 mg Twice Daily in Antiretroviral Treatment-Experienced Participants
Gupta S, Lataillade M, Farber S, Kozal MJ. Raltegravir With Unboosted Atazanavir 300 mg Twice Daily in Antiretroviral Treatment-Experienced Participants. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2009, 8: 87-92. PMID: 19270153, DOI: 10.1177/1545109709332471.Peer-Reviewed Original ResearchConceptsMean CD4 count increaseCD4 count increaseCombination of raltegravirTreatment-experienced patientsPotent antiretroviral activityCopies/mLProtease inhibitorsARV agentsUnboosted atazanavirHIV RNAImmunologic outcomesTwice DailyAntiretroviral treatmentARV therapyAntiretroviral agentsCase seriesHIV integrase inhibitorsTherapeutic failureAntiretroviral activityRaltegravirAtazanavirIntegrase inhibitorsAdverse effectsCells/Count increaseHepatitis B Virus Infection in US Correctional Facilities: A Review of Diagnosis, Management, and Public Health Implications
Gupta S, Altice FL. Hepatitis B Virus Infection in US Correctional Facilities: A Review of Diagnosis, Management, and Public Health Implications. Journal Of Urban Health 2009, 86: 263-279. PMID: 19184447, PMCID: PMC2648882, DOI: 10.1007/s11524-008-9338-z.BooksConceptsChronic viral infectionsHepatitis B virus infectionB virus infectionReview of diagnosisHBV infectionViral infectionVirus infectionMedical careChronic HBV infectionChronic hepatitis BChronic medical conditionsComprehensive medical carePublic health burdenPublic health impactHigh-risk behaviorsPublic health implicationsProvision of vaccinationUS correctional facilitiesCorrectional settingsHBV vaccineHepatitis BViral hepatitisTreatment guidelinesChronic infectionChronic illness