2020
Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission.
Guzeloglu-Kayisli O, Guo X, Tang Z, Semerci N, Ozmen A, Larsen K, Mutluay D, Guller S, Schatz F, Kayisli UA, Lockwood CJ. Zika Virus-Infected Decidual Cells Elicit a Gestational Age-Dependent Innate Immune Response and Exaggerate Trophoblast Zika Permissiveness: Implication for Vertical Transmission. The Journal Of Immunology 2020, 205: 3083-3094. PMID: 33139490, DOI: 10.4049/jimmunol.2000713.Peer-Reviewed Original ResearchConceptsHuman decidual cellsDecidual cellsZika virusViral attachment factorsTerm decidual stromal cellsVertical transmissionDecidual cell supernatantsTerm decidual cellsInnate immune response genesInnate immune responsivenessExact pathogenic mechanismDecidual stromal cellsHuman first trimesterInnate immune responseSevere fetal defectsImmune response genesFetal sequelaeGestational ageFirst trimesterPlacental transmissionZIKV infectionCytotrophoblast culturesImmune responsivenessZika infectionLate pregnancy
2005
Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts
Lee MJ, Wang Z, Yee H, Ma Y, Swenson N, Yang L, Kadner SS, Baergen RN, Logan SK, Garabedian MJ, Guller S. Expression and Regulation of Glucocorticoid Receptor in Human Placental Villous Fibroblasts. Endocrinology 2005, 146: 4619-4626. PMID: 16055431, DOI: 10.1210/en.2005-0235.Peer-Reviewed Original ResearchConceptsGC receptorSmooth muscle cellsHuman placentaGR levelsHormone treatmentShort-term GC treatmentMuscle cellsLong-term hormone treatmentVascular smooth muscle cellsGR protein expressionGR mRNA levelsPlacental cell typesNormal term human placentasTotal GR levelsTerm human placentaCell typesGR antibodyGC treatmentHormone exposureStem villiCytotrophoblast cellsGlucocorticoid receptorPlacental fibroblastsTerminal villiVillous fibroblasts
1998
Apoptosis and Fas Expression in Human Fetal Membranes1
Runić R, Lockwood C, LaChapelle L, Dipasquale B, Demopoulos R, Kumar A, Guller S. Apoptosis and Fas Expression in Human Fetal Membranes1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 660-666. PMID: 9467589, DOI: 10.1210/jcem.83.2.4600.Peer-Reviewed Original ResearchConceptsChorionic trophoblastsHuman fetal membranesFetal membranesApoptotic indexWeeks groupCell layerHuman fetal membrane cellsCytoplasmic domain of FasFetal membrane cellsFas messenger ribonucleic acidTrophoblast cell layerDecidual cell typesCondensation of chromatinConsistent with apoptosisSamples of amnionEpithelial cell layerMessenger ribonucleic acidCell surface receptorsWeeks gestationDecidual cellsProstate glandAmnion epitheliumFas signalingAmniotic tissueImmunohistochemical staining