2023
Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis
Ozmen A, Nwabuobi C, Tang Z, Guo X, Larsen K, Guller S, Blas J, Moore M, Kayisli U, Lockwood C, Guzeloglu-Kayisli O. Leptin-Mediated Induction of IL-6 Expression in Hofbauer Cells Contributes to Preeclampsia Pathogenesis. International Journal Of Molecular Sciences 2023, 25: 135. PMID: 38203306, PMCID: PMC10778808, DOI: 10.3390/ijms25010135.Peer-Reviewed Original ResearchConceptsIL-6 expressionHofbauer cellsP65 NF-κBIL-6NF-κBLeptin levelsPreeclampsia pathogenesisElevated serum interleukin-6 levelsSerum interleukin-6 levelsERK1/2 MAPKInterleukin-6 levelsPro-inflammatory phenotypeAnti-inflammatory phenotypeLeptin receptor expressionIL-6 productionPathogenesis of PEPlacental leptin productionPhosphorylation levelsERK1/2 MAPK inhibitorIL-6 regulationConcentration-dependent mannerPE patientsHuman pregnancySecond trimesterLeptin concentrations
2012
Toll‐Like Receptor 4 Expression in Decidual Cells and Interstitial Trophoblasts Across Human Pregnancy
Schatz F, Kayisli UA, Vatandaslar E, Ocak N, Guller S, Abrahams VM, Krikun G, Lockwood CJ. Toll‐Like Receptor 4 Expression in Decidual Cells and Interstitial Trophoblasts Across Human Pregnancy. American Journal Of Reproductive Immunology 2012, 68: 146-153. PMID: 22564191, PMCID: PMC3395732, DOI: 10.1111/j.1600-0897.2012.01148.x.Peer-Reviewed Original ResearchConceptsToll-like receptor 4Interstitial trophoblastDecidual cellsDanger signalsToll-like receptor 4 expressionFirst trimester decidual cellsReceptor 4 expressionHuman pregnancyElective terminationNormal deliveryDecidua parietalisReceptor 4Luteal phaseStromal cellsGram-negative bacteriaSerial sectionsTrophoblastPrimary targetCellsClose contactEndometriumPregnancyHScoreGestationCytokeratin
1999
Steroid Regulation of Human Placental Integrins: Suppression ofα 2 Integrin Expression in Cytotrophoblasts by Glucocorticoids1
Ryu J, Majeska R, Ma Y, LaChapelle L, Guller S. Steroid Regulation of Human Placental Integrins: Suppression ofα 2 Integrin Expression in Cytotrophoblasts by Glucocorticoids1. Endocrinology 1999, 140: 3904-3908. DOI: 10.1210/en.140.9.3904.Peer-Reviewed Original ResearchExtracellular matrix ligandsHuman cytotrophoblastsControl levelsMessenger RNATreatment of cytotrophoblastsMRNA levelsIntegrin subunitsCell surface expressionHuman term placentaExtracellular matrixDays of treatmentHuman pregnancyExpression of collagenHeterodimeric transmembrane glycoproteinsTerm placentaCytotrophoblastDexamethasone effectDown-regulated expressionHuman placentaSurface expressionCellular adhesion receptorsDexamethasoneGC treatmentGlucocorticoidIntegrin levels
1994
Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta
Guller S, Markiewicz L, Wozniak R, Burnham J, Wang E, Kaplan P, Lockwood C. Developmental regulation of glucocorticoid-mediated effects on extracellular matrix protein expression in the human placenta. Endocrinology 1994, 134: 2064-2071. DOI: 10.1210/en.134.5.2064.Peer-Reviewed Original ResearchEffects of glucocorticoidsTerm cellsLevels of glucocorticoidsTrimester cellsDexamethasone treatmentTrimester of human pregnancyControl levelsGlucocorticoid responseSeparation of placentaTreatment of cytotrophoblastsLevels of hCGControl valuesIncreased glucocorticoid responseHuman first trimesterLow levels of glucocorticoidsGlucocorticoid-mediated effectsLevels of FN mRNARates of FNElevated levels of glucocorticoidsExtracellular matrix protein expressionLevels of FNCytotrophoblast culturesReduced glucocorticoid responsivenessHuman pregnancyFirst-trimester