2023
Aging a Decade in a Day: Age Cutoff Bias in Adjuvant Therapy Allocation for Early-Stage Breast Cancer
Talcott W, Cain D, Yang D, Mougalian S, Evans S. Aging a Decade in a Day: Age Cutoff Bias in Adjuvant Therapy Allocation for Early-Stage Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2023, 116: 747-756. PMID: 37125983, DOI: 10.1016/j.ijrobp.2022.12.057.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerAdjuvant therapy recommendationsMultivariable logistic regressionTherapy recommendationsBreast cancerAge 70Cohort 2Odds ratioCohort 1Years age differenceLogistic regressionNational Cancer DatabaseHigh-risk featuresHormone receptor positivityConfidence intervalsAdjuvant treatmentEndocrine therapyPatient ageIndependent predictorsReceptor positivityTherapy allocationAge 69Cancer DatabaseTreatment allocationAge differences
2021
Patterns of treatment with everolimus exemestane in hormone receptor-positive HER2-negative metastatic breast cancer in the era of targeted therapy
Rozenblit M, Mun S, Soulos P, Adelson K, Pusztai L, Mougalian S. Patterns of treatment with everolimus exemestane in hormone receptor-positive HER2-negative metastatic breast cancer in the era of targeted therapy. Breast Cancer Research 2021, 23: 14. PMID: 33514405, PMCID: PMC7844919, DOI: 10.1186/s13058-021-01394-y.Peer-Reviewed Original ResearchConceptsPrior endocrine therapyEndocrine therapyMetastatic breast cancerEffective treatment optionTreatment optionsBreast cancerMedian treatmentMedian OSEE therapyHormone receptor-positive HER2-negative metastatic breast cancerMultivariable Cox proportional hazards regression analysisHER2-negative metastatic breast cancerPrior treatmentCox proportional hazards regression analysisFirst-line therapy initiationProportional hazards regression analysisPrior treatment optionsLines of therapyProportion of patientsKaplan-Meier methodHazards regression analysisPatterns of treatmentElectronic health record-derived dataClinical trial dataOS benefit