2022
Ethical analysis examining the prioritisation of living donor transplantation in times of healthcare rationing
Kulkarni S, Flescher A, Ahmad M, Bayliss G, Bearl D, Biondi L, Davis E, George R, Gordon E, Lyons T, Wightman A, Ladin K. Ethical analysis examining the prioritisation of living donor transplantation in times of healthcare rationing. Journal Of Medical Ethics 2022, 49: 389-392. PMID: 34983855, PMCID: PMC10314075, DOI: 10.1136/medethics-2021-107574.Peer-Reviewed Original ResearchConceptsTransplant communityDonor transplantsTransplant hospitalsSARS-CoV-2 infectionHealth systemEnd-stage liverSARS-CoV-2Exposure riskDonor transplantationTransplant proceduresUnited NetworkKidney diseaseDialysis centersElective proceduresPatient preparednessTransplantEarly detectionCOVID-19 pandemicRiskHospitalRecipientsTier 3BAcceptable riskCareImportant option
2021
Quantifying Risk Tolerance Among Potential Living Kidney Donors With the Donor-Specific Risk Questionnaire
Thiessen C, Gannon J, Li S, Skrip L, Dobosz D, Gan G, Deng Y, Kennedy K, Gray D, Mussell A, Reese PP, Gordon EJ, Kulkarni S. Quantifying Risk Tolerance Among Potential Living Kidney Donors With the Donor-Specific Risk Questionnaire. American Journal Of Kidney Diseases 2021, 78: 246-258. PMID: 33508397, DOI: 10.1053/j.ajkd.2020.11.028.Peer-Reviewed Original ResearchConceptsKidney failure riskKidney failureDonor evaluationRisk QuestionnaireGreater patient-centered carePotential Living Kidney DonorsRisk estimatesKidney transplant centersKidney donor evaluationMultivariable logistic regressionLiving Kidney DonorsTime of enrollmentPatient-centered careTransplant centersTransplant teamKidney donorsRisk groupsPatient engagementAbstractTextLogistic regressionStudy designLongitudinal mixed-methods studyRecipientsMixed-methods studyRisk threshold
2020
Reply to “Ethical principles governing organ transplantation apply to paired exchange programs”
Ladin K, Kulkarni S. Reply to “Ethical principles governing organ transplantation apply to paired exchange programs”. American Journal Of Transplantation 2020, 20: 1758-1759. PMID: 32337792, DOI: 10.1111/ajt.15945.Peer-Reviewed Original ResearchEthical principles governing organ transplantation apply to paired exchange programs
Kulkarni S, Ladin K. Ethical principles governing organ transplantation apply to paired exchange programs. American Journal Of Transplantation 2020, 20: 1223-1224. PMID: 32022980, PMCID: PMC7217160, DOI: 10.1111/ajt.15807.Peer-Reviewed Original Research
2017
Assessing Living Donor Priorities Through Nominal Group Technique
Dorflinger LM, Kulkarni S, Thiessen C, Klarman S, Fraenkel L. Assessing Living Donor Priorities Through Nominal Group Technique. Progress In Transplantation 2017, 28: 29-35. PMID: 29243533, PMCID: PMC5735019, DOI: 10.1177/1526924817746682.Peer-Reviewed Original ResearchConceptsImpact of donationMost salientDonation decisionsNominal group techniquePersonal benefitsFuture researchAddress factorsMost peopleParticipantsAltruismLifestyle factorsTransplant programsNumber of donorsFuture healthCampaign effortsIndividualsPotential donorsKidneyPublic campaignsSupportGroup techniqueSalientLack of knowledgeDonationDecisionsOpting out: a single-centre pilot study assessing the reasons for and the psychosocial impact of withdrawing from living kidney donor evaluation
Thiessen C, Jaji Z, Joyce M, Zimbrean P, Reese P, Gordon EJ, Kulkarni S. Opting out: a single-centre pilot study assessing the reasons for and the psychosocial impact of withdrawing from living kidney donor evaluation. Journal Of Medical Ethics 2017, 43: 756. PMID: 28258071, DOI: 10.1136/medethics-2016-103512.Peer-Reviewed Original ResearchConceptsSingle-center pilot studyKidney donor evaluationUS transplant centersPotential living donorsPostoperative periodTransplant centersDonor evaluationLiving donorsKidney donationModifiable barriersPsychosocial impactStudy participantsPilot studyDonor advocateFinancial burdenDonor autonomyQualitative studyDonationIndividualsParticipantsVaried reasons
2016
A Call for Research on Individuals Who Opt Out of Living Kidney Donation
Thiessen C, Kulkarni S, Reese PP, Gordon EJ. A Call for Research on Individuals Who Opt Out of Living Kidney Donation. Transplantation 2016, 100: 2527-2532. PMID: 27495760, DOI: 10.1097/tp.0000000000001408.Peer-Reviewed Original ResearchEculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial
Kulkarni S, Kirkiles‐Smith N, Deng YH, Formica RN, Moeckel G, Broecker V, Bow L, Tomlin R, Pober JS. Eculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial. American Journal Of Transplantation 2016, 17: 682-691. PMID: 27501352, DOI: 10.1111/ajt.14001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntibodies, Monoclonal, HumanizedChronic DiseaseComplement C5Complement Inactivating AgentsEarly Intervention, EducationalFemaleFollow-Up StudiesGlomerular Filtration RateGraft RejectionGraft SurvivalHumansIsoantibodiesKidney Failure, ChronicKidney Function TestsKidney TransplantationLiving DonorsMaleMiddle AgedPilot ProjectsPrognosisRisk FactorsTissue DonorsTransplant RecipientsYoung AdultConceptsDe novo donor-specific antibodiesComplement inhibitionTreatment groupsNovo donor-specific antibodiesAntibody-Mediated InjuryC1q-positive patientsDonor-specific antibodiesKidney transplant recipientsPrimary end pointEndothelial cell injuryMo of observationEculizumab therapyEculizumab treatmentHumoral injuryTransplant recipientsKidney transplantRenal functionKidney functionChronic settingEGFR trajectoriesTreatment periodCell injuryPatientsEnd pointPercentage changeThe Long‐Term Follow‐up and Support for Living Organ Donors: A Center‐Based Initiative Founded on Developing a Community of Living Donors
Kulkarni S, Thiessen C, Formica RN, Schilsky M, Mulligan D, D'Aquila R. The Long‐Term Follow‐up and Support for Living Organ Donors: A Center‐Based Initiative Founded on Developing a Community of Living Donors. American Journal Of Transplantation 2016, 16: 3385-3391. PMID: 27500361, DOI: 10.1111/ajt.14005.Peer-Reviewed Original Research
2015
Development of a Donor-Centered Approach to Risk Assessment: Rebalancing Nonmaleficence and Autonomy
Thiessen C, Gordon EJ, Reese PP, Kulkarni S. Development of a Donor-Centered Approach to Risk Assessment: Rebalancing Nonmaleficence and Autonomy. American Journal Of Transplantation 2015, 15: 2314-2323. PMID: 25868787, DOI: 10.1111/ajt.13272.Peer-Reviewed Original Research
2014
Opting out: confidentiality and availability of an ‘alibi’ for potential living kidney donors in the USA
Thiessen C, Kim YA, Formica R, Bia M, Kulkarni S. Opting out: confidentiality and availability of an ‘alibi’ for potential living kidney donors in the USA. Journal Of Medical Ethics 2014, 41: 506. PMID: 25368413, DOI: 10.1136/medethics-2014-102184.Peer-Reviewed Original ResearchMeSH KeywordsConfidentialityConsent FormsHumansKidney TransplantationLiving DonorsTissue and Organ ProcurementWritten informed consent for living liver donor evaluation: Compliance with centers for medicare and medicaid services and organ procurement and transplantation network guidelines and alibi offers
Thiessen C, Kim YA, Yoo PS, Rodriguez‐Davalos M, Mulligan D, Kulkarni S. Written informed consent for living liver donor evaluation: Compliance with centers for medicare and medicaid services and organ procurement and transplantation network guidelines and alibi offers. Liver Transplantation 2014, 20: 416-424. PMID: 24415564, DOI: 10.1002/lt.23822.Peer-Reviewed Original Research
2013
CT angiography in potential living kidney donors: 80 kVp versus 120 kVp.
Davarpanah AH, Pahade JK, Cornfeld D, Ghita M, Kulkarni S, Israel GM. CT angiography in potential living kidney donors: 80 kVp versus 120 kVp. American Journal Of Roentgenology 2013, 201: w753-60. PMID: 24147505, DOI: 10.2214/ajr.12.10439.Peer-Reviewed Original ResearchWritten Informed Consent for Living Kidney Donors: Practices and Compliance With CMS and OPTN Requirements
Thiessen C, Kim YA, Formica R, Bia M, Kulkarni S. Written Informed Consent for Living Kidney Donors: Practices and Compliance With CMS and OPTN Requirements. American Journal Of Transplantation 2013, 13: 2713-2721. PMID: 24020884, DOI: 10.1111/ajt.12406.Peer-Reviewed Original ResearchConceptsConsent formKidney donorsKidney donor evaluationLiving Kidney DonorsKidney transplantRoutine followTransplant centersDonor evaluationUS CentersOPTN policyOrgan procurementHealth problemsInformed consentInformed consent practicesPrior yearSurgeryDonor consentConsentConsent practicesDonorsComplicationsTransplantComplianceFollowYearsRetrocaval Renal Artery Bifurcation Is Not a Contraindication to Laparoscopic Right Donor Nephrectomy
Gandelman JA, Yoo PS, Kulkarni S. Retrocaval Renal Artery Bifurcation Is Not a Contraindication to Laparoscopic Right Donor Nephrectomy. Journal Of The American College Of Surgeons 2013, 217: 406-411. PMID: 23791562, DOI: 10.1016/j.jamcollsurg.2013.03.026.Peer-Reviewed Original ResearchConceptsDelayed graft functionLaparoscopic donor nephrectomyDonor nephrectomyGraft functionRecipient outcomesExact testRight-sided laparoscopic donor nephrectomyLaparoscopic right donor nephrectomyBifurcation groupComplex arterial anatomyLeft-sided kidneyOutcomes 30 daysRenal artery bifurcationRight donor nephrectomyRight-sided kidneyRight renal arteryLeft-sided nephrectomyCommon anatomic variantFisher's exact testMann-Whitney U testNonbifurcation groupTotal nephrectomyUreteral complicationsComplication rateCreatinine clearance
2012
Complication Arising from a Duplicated Inferior Vena Cava following Laparoscopic Living Donor Nephrectomy: A Case Report
Christakis P, Cimsit B, Kulkarni S. Complication Arising from a Duplicated Inferior Vena Cava following Laparoscopic Living Donor Nephrectomy: A Case Report. Transplantation Proceedings 2012, 44: 1450-1452. PMID: 22664034, DOI: 10.1016/j.transproceed.2011.11.064.Peer-Reviewed Original ResearchConceptsLaparoscopic living-donor nephrectomyLiving Donor NephrectomyDonor nephrectomyInferior vena cavaVena cavaMultiple emergency room visitsLeft gonadal veinEmergency room visitsEasier surgical approachIntraoperative ligationPostoperative courseFunctioning kidneyGonadal veinRenal veinRoom visitsInferior venaLeft kidneyLikely etiologySurgical approachCase reportRenal vasculatureNephrectomyCavaKidneyPatients
2011
Multidetector CT angiography in living donor renal transplantation: accuracy and discrepancies in right venous anatomy
Kulkarni S, Emre S, Arvelakis A, Asch W, Bia M, Formica R, Israel G. Multidetector CT angiography in living donor renal transplantation: accuracy and discrepancies in right venous anatomy. Clinical Transplantation 2011, 25: 77-82. PMID: 20070320, DOI: 10.1111/j.1399-0012.2009.01193.x.Peer-Reviewed Original ResearchConceptsVenous anatomyVenous phaseMDCT angiographyRenal anatomyCircumaortic renal veinDonor renal transplantationEarly arterial bifurcationLate venous confluenceMultiple arterial anomaliesRight donor nephrectomyIntra-operative findingsMultiple venous anomaliesContrast-enhanced phasesArterial anomaliesRetroaortic veinRenal transplantationDonor nephrectomyMultiple arteriesVenous anomaliesRenal veinVenous confluenceKidney donorsTomography angiographyAnatomical variantsDonor anatomy
2008
Living kidney donor informed consent practices vary between US and non-US centers
Parekh AM, Gordon EJ, Garg AX, Waterman AD, Kulkarni S, Parikh CR. Living kidney donor informed consent practices vary between US and non-US centers. Nephrology Dialysis Transplantation 2008, 23: 3316-3324. PMID: 18599559, PMCID: PMC2720811, DOI: 10.1093/ndt/gfn295.Peer-Reviewed Original ResearchConceptsTransplant centersDonor riskInformed consentKidney donorsPsychosocial evaluationNon-US respondentsWorld Transplant CongressChronic kidney diseaseUS transplant centersPotential donorsKidney donation ratesMedical complicationsDonor evaluationInformed consent processKidney diseaseConsensus statementUS CentersMedical riskTransplant professionalsDonation ratesOrgan donationConsent formPsychosocial risksSupport groupsConsent process
2006
Living donor liver transplantation for pediatric and adult recipients
Kulkarni S, Malagò M, Cronin DC. Living donor liver transplantation for pediatric and adult recipients. Nature Reviews Gastroenterology & Hepatology 2006, 3: 149-157. PMID: 16511549, DOI: 10.1038/ncpgasthep0437.Peer-Reviewed Original ResearchEthical tensions in solid organ transplantation: the price of success.
Kulkarni S, Cronin DC. Ethical tensions in solid organ transplantation: the price of success. World Journal Of Gastroenterology 2006, 12: 3259-64. PMID: 16718849, PMCID: PMC4087972, DOI: 10.3748/wjg.v12.i20.3259.Peer-Reviewed Original Research