2022
CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression
Zhang M, Liu ZZ, Aoshima K, Cai WL, Sun H, Xu T, Zhang Y, An Y, Chen JF, Chan LH, Aoshima A, Lang SM, Tang Z, Che X, Li Y, Rutter SJ, Bossuyt V, Chen X, Morrow JS, Pusztai L, Rimm DL, Yin M, Yan Q. CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression. Science Translational Medicine 2022, 14: eabf5473. PMID: 35108062, PMCID: PMC9003667, DOI: 10.1126/scitranslmed.abf5473.Peer-Reviewed Original ResearchConceptsBreast cancer metastasisReticuloendotheliosis viral oncogene homolog ACancer metastasisImmune suppressionM2 macrophagesWorse metastasis-free survivalMetastatic breast cancerMetastasis-free survivalV-rel avian reticuloendotheliosis viral oncogene homolog ACancer-related deathPrimary breast tumorsMultiple mouse modelsNF-κB signalingImmunocompetent settingNuclear factor-κB family membersMetastasis-promoting genesDistant metastasisMetastatic sitesPrimary tumorEffective therapyBreast cancerMetastasis treatmentMouse modelBreast tumorsMetastasis
2002
Korrelation von FDG-PET und MRT/CT mit der Histopathologie in Primärdiagnostik, Lymphknotenstaging und Rezidivdiagnostik von Kopf-Hals-Tumoren
Pöpperl G, Lang S, Dagdelen O, Jäger L, Tiling R, Hahn K, Tatsch K. Korrelation von FDG-PET und MRT/CT mit der Histopathologie in Primärdiagnostik, Lymphknotenstaging und Rezidivdiagnostik von Kopf-Hals-Tumoren. RöFo 2002, 174: 714-720. PMID: 12063600, DOI: 10.1055/s-2002-32215.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDiagnosis, DifferentialFemaleFluorodeoxyglucose F18HumansLymph NodesLymphatic MetastasisMagnetic Resonance ImagingMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNeoplasms, Unknown PrimaryOtorhinolaryngologic NeoplasmsPrognosisRetrospective StudiesSensitivity and SpecificityTomography, Emission-ComputedTomography, X-Ray ComputedConceptsLymph node metastasisCervical lymph node metastasisDiagnosis of primary tumorLymph node involvementPrimary tumorPre-surgical diagnosisTumor recurrenceNode metastasisFDG-PETNode involvementPrimary lesionHistopathological findingsDiagnostic value of FDG-PETStaging of head and neck cancerPrimary lymph node involvementDiagnosis of tumor recurrenceHead and neck cancerTumor diameter <Occult primary tumorDetect tumor recurrenceMorphological imaging modalitiesRecurrent tumorsPT1 stageNeck cancerPatient prognosis