2016
Does prenatal stress alter the developing connectome?
Scheinost D, Sinha R, Cross SN, Kwon SH, Sze G, Constable RT, Ment LR. Does prenatal stress alter the developing connectome? Pediatric Research 2016, 81: 214-226. PMID: 27673421, PMCID: PMC5313513, DOI: 10.1038/pr.2016.197.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderStress-related symptomsPrenatal exposureRisk factorsMajor depressionFetal brainMaternal stressPrenatal stressNeural elementsNeurobehavioral disordersFunctional connectivityHyperactivity disorderHuman neurodevelopmentDisordersAutism spectrum disorderFunctional networksConnectomeSpectrum disorderHuman connectomePregnancySymptomsNeurodevelopmentSchizophreniaBrainPrenatal stress alters amygdala functional connectivity in preterm neonates
Scheinost D, Kwon SH, Lacadie C, Sze G, Sinha R, Constable RT, Ment LR. Prenatal stress alters amygdala functional connectivity in preterm neonates. NeuroImage Clinical 2016, 12: 381-388. PMID: 27622134, PMCID: PMC5009231, DOI: 10.1016/j.nicl.2016.08.010.Peer-Reviewed Original ResearchConceptsPrenatal stress exposurePreterm neonatesPreterm birthPrenatal stressStress exposureTerm controlsFunctional connectivityAmygdala connectivityNeuropsychiatric disordersResting-state functional magnetic resonance imagingPrenatal stress altersEarly life stressFunctional magnetic resonance imagingMagnetic resonance imagingPeristriate cortexPrenatal exposureHigh riskMaternal stressIndependent cohortNeonatesLeft amygdalaSubcortical regionsResonance imagingAmygdalaCohort
2015
Alterations in Anatomical Covariance in the Prematurely Born
Scheinost D, Kwon SH, Lacadie C, Vohr BR, Schneider KC, Papademetris X, Constable RT, Ment LR. Alterations in Anatomical Covariance in the Prematurely Born. Cerebral Cortex 2015, 27: 534-543. PMID: 26494796, PMCID: PMC5939217, DOI: 10.1093/cercor/bhv248.Peer-Reviewed Original ResearchPreterm birth alters neonatal, functional rich club organization
Scheinost D, Kwon SH, Shen X, Lacadie C, Schneider KC, Dai F, Ment LR, Constable RT. Preterm birth alters neonatal, functional rich club organization. Brain Structure And Function 2015, 221: 3211-3222. PMID: 26341628, PMCID: PMC4779074, DOI: 10.1007/s00429-015-1096-6.Peer-Reviewed Original ResearchConceptsPT neonatesTerm neonatesRich-club organizationPreterm birth altersTerm-equivalent ageClub organizationFunctional magnetic resonance imagingMagnetic resonance imagingPT birthBirth altersWhole-brain networksNeonatesResonance imagingPretermFunctional connectivityFunctional segregationCognitive difficultiesEquivalent ageFunctional organizationBrain
2014
GABA, Resting-State Connectivity and the Developing Brain
Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT, Ment LR. GABA, Resting-State Connectivity and the Developing Brain. Neonatology 2014, 106: 149-155. PMID: 24970028, PMCID: PMC4134402, DOI: 10.1159/000362433.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidTerm-equivalent agePreterm infantsGABA concentrationTerm controlsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansResting-state functional connectivityRegional GABA concentrationTerm control groupResonance imaging scansResting-state connectivityRight frontal lobeConcentration of GABANAA/cholineMagnetic resonance spectroscopyPreclinical dataImaging scansFrontal lobeControl groupInfantsBrainMRI dataAge