2023
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement
Hohenschurz-Schmidt D, Cherkin D, Rice A, Dworkin R, Turk D, McDermott M, Bair M, DeBar L, Edwards R, Farrar J, Kerns R, Markman J, Rowbotham M, Sherman K, Wasan A, Cowan P, Desjardins P, Ferguson M, Freeman R, Gewandter J, Gilron I, Grol-Prokopczyk H, Hertz S, Iyengar S, Kamp C, Karp B, Kleykamp B, Loeser J, Mackey S, Malamut R, McNicol E, Patel K, Sandbrink F, Schmader K, Simon L, Steiner D, Veasley C, Vollert J. Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement. Pain 2023, 164: 1457-1472. PMID: 36943273, PMCID: PMC10281023, DOI: 10.1097/j.pain.0000000000002888.Peer-Reviewed Original ResearchConceptsPragmatic trialPain treatmentClinical careSystematic reviewAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipTraditional efficacy trialsRoutine clinical careDaily clinical carePragmatic clinical trialsEvidence-based treatmentsRelated health policiesInternal validityPain assessmentClinical managementClinical trialsEfficacy trialsConsensus meetingTrial designConsensus discussionTrial objectivesSuch trialsHealth policyTrialsExpert presentations
2022
Partnering with patients in clinical trials of pain treatments: a narrative review
Holzer KJ, Veasley C, Kerns RD, Edwards RR, Gewandter JS, Langford DJ, Yaeger LH, McNicol E, Ferguson M, Turk DC, Dworkin RH, Haroutounian S. Partnering with patients in clinical trials of pain treatments: a narrative review. Pain 2022, 163: 1862-1873. PMID: 35297799, DOI: 10.1097/j.pain.0000000000002600.Peer-Reviewed Original ResearchConceptsPain treatmentClinical trialsPatient engagementNarrative reviewClinical researchPatient-centered clinical researchPain research studiesPain-related studiesMeaningful patient engagementClinical studiesPatient recruitmentPatient partnersPatientsTrialsTreatmentCurrent evaluationReviewSpecific guidance
2021
The ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value
Dworkin RH, Kerns RD, McDermott MP, Turk DC, Veasley C. The ACTTION Guide to Clinical Trials of Pain Treatments, part II: mitigating bias, maximizing value. PAIN Reports 2021, 6: e886. PMID: 33521484, PMCID: PMC7838005, DOI: 10.1097/pr9.0000000000000886.Peer-Reviewed Original Research
2018
Brief Counseling for Veterans with Musculoskeletal Disorder, Risky Substance Use, and Service Connection Claims
Rosen MI, Becker WC, Black AC, Martino S, Edens EL, Kerns RD. Brief Counseling for Veterans with Musculoskeletal Disorder, Risky Substance Use, and Service Connection Claims. Pain Medicine 2018, 20: 528-542. PMID: 29800338, PMCID: PMC6387983, DOI: 10.1093/pm/pny071.Peer-Reviewed Original ResearchConceptsRisky substance useMusculoskeletal disordersSubstance useMean pain severityCourse of illnessPain severity ratingsProportion of veteransScreening Brief InterventionCounseling armPain severityPain treatmentTAU conditionWeek 12Brief counselingEarly interventionOutcome assessmentBrief interventionStudy therapistsTelephone callsVeteransCounseling interventionCounselingInterventionSeverity ratingsDisordersAssociation Between Facility-Level Utilization of Non-pharmacologic Chronic Pain Treatment and Subsequent Initiation of Long-Term Opioid Therapy
Carey EP, Nolan C, Kerns RD, Ho PM, Frank JW. Association Between Facility-Level Utilization of Non-pharmacologic Chronic Pain Treatment and Subsequent Initiation of Long-Term Opioid Therapy. Journal Of General Internal Medicine 2018, 33: 38-45. PMID: 29633137, PMCID: PMC5902343, DOI: 10.1007/s11606-018-4324-y.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyNon-pharmacologic treatmentsFacility-level variationNon-opioid medicationsChronic painOpioid therapyTreatment modalitiesVeterans Health Administration facilitiesPatient-reported painChronic pain treatmentChronic pain careImproved patient outcomesUtilization patternsOpioid treatmentPrior calendar yearMedication utilizationPatient characteristicsPain treatmentPain careKey ResultsAmongPrimary carePatient outcomesPainGreater utilizationAdministration facilities
2017
Examining Gender as a Correlate of Self-Reported Pain Treatment Use Among Recent Service Veterans with Deployment-Related Musculoskeletal Disorders
Driscoll MA, Higgins D, Shamaskin-Garroway A, Burger A, Buta E, Goulet JL, Heapy A, Kerns RD, Brandt CA, Haskell SG. Examining Gender as a Correlate of Self-Reported Pain Treatment Use Among Recent Service Veterans with Deployment-Related Musculoskeletal Disorders. Pain Medicine 2017, 18: 1767-1777. PMID: 28379576, DOI: 10.1093/pm/pnx023.Peer-Reviewed Original ResearchConceptsPain treatment modalitiesChronic painSelf-reported useCIH servicesPain treatmentPain careMusculoskeletal conditionsTreatment modalitiesRehabilitation therapyIntegrative health servicesInterventional pain treatmentsChronic pain treatmentWomen Veterans Cohort StudyVeterans Health AdministrationMental health conditionsSelf-rated healthGender differencesSample of veteransCorrelates of SelfCohort studyPain severityCare utilizationSpecialty careTreatment useInterventional strategiesTaking ACTION to reduce pain: ACTION study rationale, design and protocol of a randomized trial of a proactive telephone-based coaching intervention for chronic musculoskeletal pain among African Americans
Bhimani RH, Cross LJ, Taylor BC, Meis LA, Fu SS, Allen KD, Krein SL, Do T, Kerns RD, Burgess DJ. Taking ACTION to reduce pain: ACTION study rationale, design and protocol of a randomized trial of a proactive telephone-based coaching intervention for chronic musculoskeletal pain among African Americans. BMC Musculoskeletal Disorders 2017, 18: 15. PMID: 28086853, PMCID: PMC5237146, DOI: 10.1186/s12891-016-1363-6.Peer-Reviewed Original ResearchConceptsChronic musculoskeletal painMusculoskeletal painTreatment outcomesHealth care service utilizationMorris Disability QuestionnairePain outcome measuresPain treatment outcomesTelephone counseling sessionsAfrican American patientsAfrican AmericansPrimary aimUsual careDisability QuestionnaireOpioid analgesicsPain outcomesPain treatmentPrimary outcomeChronic painPain assessmentTreat methodologyAmerican patientsClinical trialsPhysical functioningService utilizationOutcome measures
2016
Improving pain care through implementation of the Stepped Care Model at a multisite community health center
Anderson DR, Zlateva I, Coman EN, Khatri K, Tian T, Kerns RD. Improving pain care through implementation of the Stepped Care Model at a multisite community health center. Journal Of Pain Research 2016, Volume 9: 1021-1029. PMID: 27881926, PMCID: PMC5115680, DOI: 10.2147/jpr.s117885.Peer-Reviewed Original ResearchPrimary care providersPain knowledge scoresCommunity health centersStepped care modelPain careHealth centersCare modelMultisite community health centerFederally Qualified Health CentersOpioid treatment agreementsQualified health centersUrine drug screensDocumentation of painHealth Services frameworkSafety-net practicesElectronic health recordsOpioid prescribingChart reviewPain managementPain outcomesPain treatmentChronic painPain assessmentTreatment agreementsPrimary careDrug Counselors’ Attitudes Toward Nonpharmacologic Treatments for Chronic Pain
Oberleitner LM, Beitel M, Schottenfeld RS, Kerns RD, Doucette C, Napoleone R, Liong C, Barry DT. Drug Counselors’ Attitudes Toward Nonpharmacologic Treatments for Chronic Pain. Journal Of Addiction Medicine 2016, 10: 34-39. PMID: 26690289, PMCID: PMC4733570, DOI: 10.1097/adm.0000000000000177.Peer-Reviewed Original ResearchConceptsChronic painNonpharmacologic treatmentsDrug counselorsNonpharmacologic pain treatmentsMethadone-maintained patientsInterdisciplinary pain managementMethadone maintenance treatmentVulnerable patient populationCognitive behavioral therapyNonpharmacologic interventionsPain managementPain treatmentPain interventionsMaintenance treatmentPatient populationPainPatientsHerbal medicineGroup interventionEfficacyInterventionTreatmentPerceived EfficacyTherapyUndertreatmentAssociation between pain outcomes and race and opioid treatment: Retrospective cohort study of Veterans
Burgess DJ, Gravely AA, Nelson DB, Bair MJ, Kerns RD, Higgins DM, Farmer MM, Partin MR. Association between pain outcomes and race and opioid treatment: Retrospective cohort study of Veterans. The Journal Of Rehabilitation Research And Development 2016, 53: 13-24. PMID: 26933921, DOI: 10.1682/jrrd.2014.10.0252.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyIndex visitOpioid prescriptionsPain outcomesCohort studyMusculoskeletal painPain treatmentPain interferenceBenefits of opioidsElectronic medical record dataGreater pain interferencePharmacologic pain treatmentsChronic noncancer painVeterans Affairs patientsChronic musculoskeletal painMedical record dataNoncancer painOpioid treatmentMost patientsVA patientsVA SurveyAlternative treatmentPatientsSignificant associationPain
2015
Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review
Dworkin JD, McKeown A, Farrar JT, Gilron I, Hunsinger M, Kerns RD, McDermott MP, Rappaport BA, Turk DC, Dworkin RH, Gewandter JS. Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review. Journal Of Clinical Epidemiology 2015, 72: 56-65. PMID: 26597977, DOI: 10.1016/j.jclinepi.2015.10.019.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsPain treatmentPrimary analysisSystematic reviewNonpharmacologic pain treatmentsRecent randomized trialsJournal of PainQuality of reportingHalf of studiesClinical trial publicationsPercent of studiesNoninterventional trialStatistical methodsPrimary outcomeRandomized trialsClinical trialsTrial publicationsPainTrial resultsTrialsStatistical methodologyTreatmentReviewDeficiencyReporting
2014
Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations
Gewandter JS, Dworkin RH, Turk DC, McDermott MP, Baron R, Gastonguay MR, Gilron I, Katz NP, Mehta C, Raja SN, Senn S, Taylor C, Cowan P, Desjardins P, Dimitrova R, Dionne R, Farrar JT, Hewitt DJ, Iyengar S, Jay GW, Kalso E, Kerns RD, Leff R, Leong M, Petersen KL, Ravina BM, Rauschkolb C, Rice ASC, Rowbotham MC, Sampaio C, Sindrup S, Stauffer JW, Steigerwald I, Stewart J, Tobias J, Treede RD, Wallace M, White RE. Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations. Pain 2014, 155: 1683-1695. PMID: 24865794, PMCID: PMC4500524, DOI: 10.1016/j.pain.2014.05.025.Peer-Reviewed Original ResearchConceptsClinical trialsPain treatmentConfirmatory trialsPOC trialsChronic pain clinical trialsEfficacious pain treatmentsPain clinical trialsSingle-dose studyChronic pain treatmentConcept clinical trialPharmacokinetic-pharmacodynamic relationshipsSequential parallel comparison designIMMPACT recommendationsActive comparatorPatient populationConsensus meetingIneffective treatmentRapid onsetTrial designNovel treatmentsCrossover designTrial durationTrialsEnriched designStudy power
2012
Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations
Dworkin RH, Turk DC, Peirce-Sandner S, Burke LB, Farrar JT, Gilron I, Jensen MP, Katz NP, Raja SN, Rappaport BA, Rowbotham MC, Backonja M, Baron R, Bellamy N, Bhagwagar Z, Costello A, Cowan P, Fang WC, Hertz S, Jay GW, Junor R, Kerns RD, Kerwin R, Kopecky EA, Lissin D, Malamut R, Markman JD, McDermott MP, Munera C, Porter L, Rauschkolb C, Rice ASC, Sampaio C, Skljarevski V, Sommerville K, Stacey BR, Steigerwald I, Tobias J, Trentacosti AM, Wasan AD, Wells GA, Williams J, Witter J, Ziegler D. Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations. Pain 2012, 153: 1148-1158. PMID: 22494920, DOI: 10.1016/j.pain.2012.03.003.Peer-Reviewed Original ResearchConceptsRecent randomized clinical trialsClinical trialsAnalgesic treatmentChronic pain clinical trialsPain clinical trialsAnalgesic drug developmentChronic pain treatmentChronic pain trialsRandomized clinical trialsAnalgesic clinical trialsNumber of patientsEvidence-based approachIMMPACT recommendationsPain treatmentPain trialsPharmacologic treatmentAnalgesic trialsPain assessmentAssay sensitivityEfficacious medicationsConsensus meetingNegative trialsImproved efficacyStudy designTrials
2011
Psychological Treatment of Chronic Pain
Kerns RD, Sellinger J, Goodin BR. Psychological Treatment of Chronic Pain. Annual Review Of Clinical Psychology 2011, 7: 411-434. PMID: 21128783, DOI: 10.1146/annurev-clinpsy-090310-120430.Peer-Reviewed Original ResearchConceptsPsychological treatmentExperience of painPsychological researchIndividual differencesCommitment interventionEmotional factorsEmotional distressPain-related disabilityBiopsychosocial modelOlder adultsChronic painFuture interventionsInterdisciplinary planInterventionDistressPain treatmentChildrenAdultsPersonsDisabilityExperiencePain careCentral roleAcceptanceResearch
2010
The Moderating Effect of Obesity on Cognitive–Behavioral Pain Treatment Outcomes
Sellinger JJ, Clark EA, Shulman M, Rosenberger PH, Heapy AA, Kerns RD. The Moderating Effect of Obesity on Cognitive–Behavioral Pain Treatment Outcomes. Pain Medicine 2010, 11: 1381-1390. PMID: 20735748, DOI: 10.1111/j.1526-4637.2010.00935.x.Peer-Reviewed Original ResearchConceptsBody mass indexNon-obese participantsPain treatment outcomesMass indexTreatment outcomesSF-36Roland-Morris Disability QuestionnaireChronic low back painAverage body mass indexLow back pain outcomesPain treatment interventionsVeterans SF-36Morris Disability QuestionnaireNon-obese groupAverage pain intensityBack pain outcomesLow back painNumerical rating scaleRole of BMIMeasures of disabilityBeck Depression InventoryDisability QuestionnairePain treatmentBack painPain conditions
2007
Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations
Dworkin RH, Turk DC, Wyrwich KW, Beaton D, Cleeland CS, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Ader DN, Brandenburg N, Burke LB, Cella D, Chandler J, Cowan P, Dimitrova R, Dionne R, Hertz S, Jadad AR, Katz NP, Kehlet H, Kramer LD, Manning DC, McCormick C, McDermott MP, McQuay HJ, Patel S, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Revicki DA, Rothman M, Schmader KE, Stacey BR, Stauffer JW, von Stein T, White RE, Witter J, Zavisic S. Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations. Journal Of Pain 2007, 9: 105-121. PMID: 18055266, DOI: 10.1016/j.jpain.2007.09.005.Peer-Reviewed Original ResearchConceptsChronic pain clinical trialsPain clinical trialsChronic pain treatmentClinical trialsSpecific outcome measuresClinical importanceTreatment outcomesOutcome measuresPain treatmentBrief Pain Inventory-InterferenceClinical trial outcome measuresPatient Global ImpressionChronic pain outcomesNumerical rating scaleTrial outcome measuresMultidimensional Pain InventoryPatient self-help organizationsBeck Depression InventoryIMMPACT recommendationsPain intensityPain outcomesPain InventoryChronic painPain assessmentGlobal Impression
2006
The Prevalence and Age-Related Characteristics of Pain in a Sample of Women Veterans Receiving Primary Care
Haskell SG, Heapy A, Reid MC, Papas RK, Kerns RD. The Prevalence and Age-Related Characteristics of Pain in a Sample of Women Veterans Receiving Primary Care. Journal Of Women's Health 2006, 15: 862-869. PMID: 16999642, DOI: 10.1089/jwh.2006.15.862.Peer-Reviewed Original ResearchConceptsWomen veteransPain problemsPrimary careHealth clinicsHealth centersHigh prevalenceVA women’s health clinicAnalgesic medication useOngoing pain problemsPrevalence of painMental health visitsAverage pain intensityCharacteristics of painWomen's health clinicWomen's health centersPain intensity levelsPain prevalenceAnalgesic medicationPain sitesPain statusHealth visitsMedication usePain intensityPain treatmentRoutine appointments
2005
Intersession coping skill practice mediates the relationship between readiness for self-management treatment and goal accomplishment
Heapy A, Otis J, Marcus KS, Frantsve LM, Janke E, Shulman M, Bellmore W, Kerns RD. Intersession coping skill practice mediates the relationship between readiness for self-management treatment and goal accomplishment. Pain 2005, 118: 360-368. PMID: 16289803, DOI: 10.1016/j.pain.2005.09.004.Peer-Reviewed Original ResearchConceptsSelf-management treatmentCognitive behavioral therapySelf-management approachPain treatmentChronic painVA primary care clinicsPrimary care clinicsPain ReadinessCare clinicsPain StagesPatient readinessPrimary careImproved outcomesTreatment benefitTreatment goalsSkills practicePractice recommendationsAdherence ratingsAdherenceChange QuestionnairePSOCQPainPatientsTreatmentSelf-efficacy ratingsPredictive validity of pain readiness to change and self-efficacy for adherence and goal accomplishment in pain treatment
Heapy A, Otis J, Marcus K, Frantsve L, Janke E, Shulman M, Kerns R. Predictive validity of pain readiness to change and self-efficacy for adherence and goal accomplishment in pain treatment. Journal Of Pain 2005, 6: s65. DOI: 10.1016/j.jpain.2005.01.257.Peer-Reviewed Original Research
2004
A critical review of the pain readiness to change model
Kerns RD, Habib S. A critical review of the pain readiness to change model. Journal Of Pain 2004, 5: 357-367. PMID: 15501193, DOI: 10.1016/j.jpain.2004.06.005.Peer-Reviewed Original Research