2020
Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions
Percy J, Zaveri H, Duckrow RB, Gerrard J, Farooque P, Hirsch LJ, Spencer DD, Sivaraju A. Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions. Epilepsy & Behavior 2020, 111: 107231. PMID: 32615416, DOI: 10.1016/j.yebeh.2020.107231.Peer-Reviewed Original ResearchConceptsLong-term seizure freedomSeizure freedomSeizure frequencyElectrode implantationIntracranial studiesLong-term seizure reductionAdditional surgical interventionSeizure onset localizationIntracranial electroencephalogram monitoringSeizure reductionConsecutive patientsSurgical interventionEpileptogenic networksElectroencephalogram monitoringNeuromodulatory effectsRetrospective analysisIntracranial monitoringTransient improvementDepth electrodesPatientsYear 4ImplantationAdequate dataYears
2016
The relationship between seizures, interictal spikes and antiepileptic drugs
Goncharova II, Alkawadri R, Gaspard N, Duckrow RB, Spencer DD, Hirsch LJ, Spencer SS, Zaveri HP. The relationship between seizures, interictal spikes and antiepileptic drugs. Clinical Neurophysiology 2016, 127: 3180-3186. PMID: 27292227, DOI: 10.1016/j.clinph.2016.05.014.Peer-Reviewed Original ResearchConceptsFirst seizureSeizure occurrenceAED taperSpike rateEEG monitoringMarker of inhibitionIntracranial EEG monitoringOccurrence of seizuresScalp EEG monitoringConsecutive patientsAntiepileptic drugsDrug taperHigh spike ratesInterictal spikesSeizuresDay 4Intracranial electrodesPatientsAEDsSignificant relationship
1992
Regional coherence and the transfer of ictal activity during seizure onset in the medial temporal lobe
Duckrow R, Spencer S. Regional coherence and the transfer of ictal activity during seizure onset in the medial temporal lobe. Clinical Neurophysiology 1992, 82: 415-422. PMID: 1375548, DOI: 10.1016/0013-4694(92)90046-k.Peer-Reviewed Original ResearchConceptsMedial temporal lobeSeizure onsetTemporal lobeBrain regionsSustained seizure activityHippocampal depth electrodesHuman medial temporal lobeConsecutive patientsResective surgerySeizure dischargesSeizure activityEpileptiform activityIctal activityPosterior hippocampusDepth electrodesNeuronal entrainmentTransient increaseIctal periodNeuronal synchronizationPossible resective surgeryEEG activityOnsetLobeAdjacent contactsSec epochs