1734-P: ADP Privation of Human Beta-Cell Mitochondria by Pyruvate Kinase
RUZ-MALDONADO I, CARDONE R, KIBBEY R. 1734-P: ADP Privation of Human Beta-Cell Mitochondria by Pyruvate Kinase. Diabetes 2024, 73 DOI: 10.2337/db24-1734-p.Peer-Reviewed Original ResearchPyruvate kinaseBeta-cell mitochondriaInhibition of OxPhosBeta-cellsHuman beta-cellsModulation of enzymesIntramitochondrial ADPPhosphoenolpyruvate inhibitionADP availabilityADP/ATP exchangeKATP channelsPhosphoenolpyruvate metabolismOxidative phosphorylationPhosphoenolpyruvateMitochondrial functionOXPHOSSubstrate transportComplex IATP/ADP ratioHuman isletsMitochondrial couplingOxygen consumption ratePyruvateMitochondriaDose-dependent mannerGlucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!
Merrins M, Kibbey R. Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model! Diabetes 2024, 73: 856-863. PMID: 38768366, PMCID: PMC11109790, DOI: 10.2337/dbi23-0032.Peer-Reviewed Original ResearchConceptsB-cell metabolismInsulin secretionEfficiency of mitochondrial ATP productionModel of glucose-stimulated insulin secretionGlucose-stimulated insulin secretionMitochondrial ATP productionNADPH productionGenetic evidenceInitial insulin secretionATP productionGlycolytic enzymesOXPHOSPyruvate kinaseATP/ADP ratioHealthy B cellsKATP channel closureB cellsDiabetes pathophysiologyGlycolysisStoichiometric yieldKATP channelsBioenergeticsATP/ADPMembrane depolarizationMetabolism