2007
Altered immunogenicity of isoaspartate containing proteins
Doyle HA, Gee RJ, Mamula MJ. Altered immunogenicity of isoaspartate containing proteins. Autoimmunity 2007, 40: 131-137. PMID: 17453712, DOI: 10.1080/08916930601165180.Peer-Reviewed Original ResearchConceptsPost-translational modificationsIsoaspartyl residuesSuch post-translational modificationsContaining ProteinBiological processesLymphocyte developmentIsoaspartic acidCytochrome cProteinAspartic acidCathepsin DCathepsin digestionPigeon cytochrome cResiduesAntigen processingAltered immunogenicityCellsImmune systemNatural modificationBone marrowToleranceD. AdditionallyEnzymeSpontaneous conversionAcid
2003
A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production
Doyle HA, Gee RJ, Mamula MJ. A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production. The Journal Of Immunology 2003, 171: 2840-2847. PMID: 12960305, DOI: 10.4049/jimmunol.171.6.2840.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensBone Marrow TransplantationCD28 AntigensCell DivisionImmunophenotypingIsoaspartic AcidLupus Erythematosus, SystemicLymph NodesLymphocyte ActivationLymphoid TissueMiceMice, Inbred C57BLMice, KnockoutMitogensPhosphorylationProtein D-Aspartate-L-Isoaspartate MethyltransferaseReceptors, Antigen, T-CellSignal TransductionT-LymphocytesConceptsProtein carboxyl methyltransferasePhosphorylation of membersSpontaneous posttranslational modificationAg receptor stimulationCarboxyl methyltransferasePosttranslational modificationsBiological functionsT cell hyperproliferationCell homeostasisCell stressImmune toleranceT cellsT cell homeostasisSystemic lupus erythematosusPeripheral immune toleranceWild-type miceCell hyperproliferationAnti-DNA autoantibodiesHomeostasisLupus erythematosusAutoantibody productionAutoimmune pathologyKidney pathologyT lymphocytesEffector functions