2012
Lupus autoimmunity altered by cellular methylation metabolism
Yang ML, Gee AJ, Gee RJ, Zurita-Lopez CI, Khare S, Clarke SG, Mamula MJ. Lupus autoimmunity altered by cellular methylation metabolism. Autoimmunity 2012, 46: 21-31. PMID: 23039363, PMCID: PMC3543504, DOI: 10.3109/08916934.2012.732133.Peer-Reviewed Original ResearchConceptsS-adenosylmethionineTCR-mediated T cell proliferationImmune responseCell proliferationLupus-prone MRL/lpr miceT-cell activation markersMRL/lpr miceTh1/Th2 cytokinesB cell immune responsesMajor methyl donorDimethylarginine residuesT cell immunityCell activation markersT cell autoreactivityT cell responsesMethylated proteinsCell immune responsesTarget of autoimmunityT cell proliferationIncubation of cellsB cell proliferationDose-dependent mannerSAM metabolismLupus autoimmunityMethylation status
1995
Self-peptides in the initiation of lupus autoimmunity.
Bockenstedt LK, Gee RJ, Mamula MJ. Self-peptides in the initiation of lupus autoimmunity. The Journal Of Immunology 1995, 154: 3516-24. PMID: 7534800, DOI: 10.4049/jimmunol.154.7.3516.Peer-Reviewed Original ResearchConceptsSm small nuclear ribonucleoproteinsT cellsAutoreactive T cell proliferationDiverse autoimmune responseSystemic lupus erythematosusT cell responsesTypes of autoimmunityT cell proliferationD proteinsLupus autoimmunityLupus erythematosusLupus autoantigensAutoimmune responseAb responsesNormal miceForeign AgsSmall nuclear ribonucleoproteinImmune systemCell responsesHigh titersImmunofluorescence patternMolecular mimicsAmino acids 26Mouse lymphocytes