2013
Autoantigens: Novel forms and presentation to the immune system
Doyle HA, Yang ML, Raycroft MT, Gee RJ, Mamula MJ. Autoantigens: Novel forms and presentation to the immune system. Autoimmunity 2013, 47: 220-233. PMID: 24191689, DOI: 10.3109/08916934.2013.850495.Peer-Reviewed Original ResearchConceptsLupus autoimmunityPresence of autoantibodiesChronic autoimmune diseaseVariety of abnormalitiesAutoantigen presentationAutoimmune diseasesClinical expressionRelated syndromesImmune systemTissue pathologyAutoimmunityNon-genetic factorsAltered pathwaysMicroenvironmental influencesDiseasePresentationCell surfaceAutoantibodiesLupusSyndromeAbnormalities
2006
Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity
Yang ML, Doyle HA, Gee RJ, Lowenson JD, Clarke S, Lawson BR, Aswad DW, Mamula MJ. Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity. The Journal Of Immunology 2006, 177: 4541-4549. PMID: 16982891, DOI: 10.4049/jimmunol.177.7.4541.Peer-Reviewed Original ResearchConceptsAutoimmune miceNZB/W miceAltered T cell functionT-cell proliferative defectsNZB/WMRL/lprT cell functionStrains of miceImmunologic responseW miceAntigenic stimulationT cellsT lymphocytesMRL miceMiceCell functionIntracellular levelsProliferative defectPhysiologic pHAgeNonenzymatic modificationAutoimmunityLymphocytesProtein processingKidneyB Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation
Yan J, Harvey BP, Gee RJ, Shlomchik MJ, Mamula MJ. B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation. The Journal Of Immunology 2006, 177: 4481-4487. PMID: 16982884, DOI: 10.4049/jimmunol.177.7.4481.Peer-Reviewed Original ResearchConceptsAutoreactive T cellsDendritic cellsT cellsB cellsAutoantigen-specific B cellsAutoimmune T cell responsesSelf-reactive T cellsAutoantigen-presenting cellsExposure of autoantigensT cell autoimmunityT cell responsesTransgenic mouse modelAutoantigen presentationCell autoimmunityIg transgenic mouse modelProfessional APCsSelf-AgMouse modelEffective APCsCell responsesVivo studiesAutoimmunityLupusAPCCells