2018
B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters
Johnson RM, Yu H, Strank N, Karunakaran K, Zhu Y, Brunham RC. B Cell Presentation of Chlamydia Antigen Selects Out Protective CD4γ13 T Cells: Implications for Genital Tract Tissue-Resident Memory Lymphocyte Clusters. Infection And Immunity 2018, 86: 10.1128/iai.00614-17. PMID: 29158429, PMCID: PMC5778355, DOI: 10.1128/iai.00614-17.Peer-Reviewed Original ResearchConceptsMemory lymphocyte clustersPeripheral blood mononuclear cellsT cell subsetsAntigen-presenting cellsT cell clonesB cell populationsT cellsLymphocyte clustersCell subsetsB cellsTissue-resident memory T cellsCD4 T-cell clonesCD4 T cell subsetsHuman peripheral blood mononuclear cellsCell clonesMemory T cellsBlood mononuclear cellsIL-13 responsesImmune B cellsB cell presentationCell populationsAdoptive transferImmune miceIntracellular bacterial pathogenChlamydia antigen
2015
Modeling the transcriptome of genital tract epithelial cells and macrophages in healthy mucosa versus mucosa inflamed by Chlamydia muridarum infection
Johnson RM, Kerr MS. Modeling the transcriptome of genital tract epithelial cells and macrophages in healthy mucosa versus mucosa inflamed by Chlamydia muridarum infection. Pathogens And Disease 2015, 73: ftv100. PMID: 26519447, PMCID: PMC4732027, DOI: 10.1093/femspd/ftv100.Peer-Reviewed Original ResearchConceptsEpithelial cellsLineage-specific differencesGene expression microarray technologyExpression microarray technologyBone marrow-derived macrophagesMarrow-derived macrophagesAdaptive immunityReproductive tract epitheliumCell line responsePrincipal cell typesMicroarray technologyIntracellular bacteriaChlamydia-specific T cellsGenital tract epithelial cellsCell typesBacterial replicationChlamydia muridarum infectionMHC class II moleculesEpithelial requirementTract epithelial cellsClass II moleculesInnate defenseHost defenseCoinhibitory ligandsInflamed/
2014
An atypical CD8 T‐cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin‐13
Johnson RM, Kerr MS, Slaven JE. An atypical CD8 T‐cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin‐13. Immunology 2014, 142: 248-257. PMID: 24428415, PMCID: PMC4008232, DOI: 10.1111/imm.12248.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD8-Positive T-LymphocytesChlamydia InfectionsChlamydia muridarumDisease Models, AnimalEpithelial CellsFemaleHumansInterleukin-13MiceMice, Inbred C57BLReproductive Tract InfectionsConceptsGenital tract infectionCD8 T cellsCD8 T cell responsesCD8 T cell clonesT cell responsesTract infectionsT cell clonesT cellsProtective immunityInterleukin-13T helper type 1 cell responsesC. muridarum genital tract infectionChlamydia muridarum Genital Tract InfectionMHC class Ia moleculesCD4 T cellsRole of TNFAntigen-presenting cellsTumor necrosis factorReproductive tract epitheliumClass Ia moleculesCD8 clonesCD8 levelsChlamydia replicationNaive splenocytesIntracellular bacterial pathogen
2013
Perforin Is Detrimental to Controllinγ C. muridarum Replication In Vitro, but Not In Vivo
Johnson RM, Kerr MS, Slaven JE. Perforin Is Detrimental to Controllinγ C. muridarum Replication In Vitro, but Not In Vivo. PLOS ONE 2013, 8: e63340. PMID: 23691028, PMCID: PMC3653963, DOI: 10.1371/journal.pone.0063340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesChlamydia muridarumEpithelial CellsFemaleGene Knockout TechniquesMiceMice, Inbred C57BLNitric Oxide Synthase Type IIPerforinReproductive Tract InfectionsConceptsGenital tract infectionPerforin knockout miceChlamydia replicationTract infectionsEpithelial cellsKnockout miceC. muridarum genital tract infectionChlamydia muridarum Genital Tract InfectionClearance mechanismsVivo clearance mechanismsCD4 T cellsT cell mechanismsT cell-epithelial cell interactionsT cell degranulationNitric oxide productionBacterial clearanceEpithelial productionCell degranulationT cellsSingle-gene knockout miceWeek 7Oxide productionPerforinNitric oxideInfection
2012
Plac8-Dependent and Inducible NO Synthase-Dependent Mechanisms Clear Chlamydia muridarum Infections from the Genital Tract
Johnson RM, Kerr MS, Slaven JE. Plac8-Dependent and Inducible NO Synthase-Dependent Mechanisms Clear Chlamydia muridarum Infections from the Genital Tract. The Journal Of Immunology 2012, 188: 1896-1904. PMID: 22238459, PMCID: PMC3303601, DOI: 10.4049/jimmunol.1102764.Peer-Reviewed Original ResearchConceptsGenital tract infectionCD4 T-cell clonesINOS-independent mechanismCD4 T cellsT cell clonesTract infectionsT cellsC. muridarum genital tract infectionCell clonesChlamydia muridarum infectionInducible NO synthase (iNOS) transcriptionT cell mechanismsT cell subsetsClearance of infectionGenital tract epitheliumT cell degranulationCytokine profileCell subsetsCell degranulationGenital tractClear infectionEffector functionsMouse modelNO productionVaccine development