2004
Peptide Hormones, Segregation Mechanism
Dannies P. Peptide Hormones, Segregation Mechanism. 2004, 573-574. DOI: 10.1016/b0-12-475570-4/01000-3.Peer-Reviewed Original ResearchPeptide Hormones, Regulated Secretion
Dannies P. Peptide Hormones, Regulated Secretion. 2004, 561-565. DOI: 10.1016/b0-12-475570-4/00998-7.Peer-Reviewed Original ResearchMembrane fusionSecretory granulesMembrane fusion processVesicular trafficSecretory pathwayProtein hormonesRegulated secretionPlasma membraneLarge dense-core vesiclesDense-core vesiclesVesiclesNeuroendocrine cellsExtracellular spaceCytosolic Ca2Release of hormonesPeptide hormonesMembraneGranulesCellsFusionYeastFusion processCytosolCa2Hormone
2001
A serum prolactin-binding protein: implications for growth hormone
Dannies P. A serum prolactin-binding protein: implications for growth hormone. Trends In Endocrinology And Metabolism 2001, 12: 427-428. PMID: 11701331, DOI: 10.1016/s1043-2760(01)00497-0.Peer-Reviewed Original ResearchConcentrating hormones into secretory granules: layers of control
Dannies P. Concentrating hormones into secretory granules: layers of control. Molecular And Cellular Endocrinology 2001, 177: 87-93. PMID: 11377824, DOI: 10.1016/s0303-7207(01)00437-3.Peer-Reviewed Original ResearchConceptsTransport of proteinsCisternal maturation modelSecretory granule proteinsSecretory granulesLayer of controlSecretory pathwayGolgi complexSoluble proteinSmall vesiclesGranule proteinsProteinPassive aggregationMaturation modelProtein hormonesSelective retentionGranulesMajor roleAggregationVesiclesHormonePathwaySortingCells
1990
Prolactin and insulin are targeted to the regulated pathway in GH4C1 cells, but their storage is differentially regulated.
Reaves B, Van Itallie C, Moore H, Dannies P. Prolactin and insulin are targeted to the regulated pathway in GH4C1 cells, but their storage is differentially regulated. Endocrinology 1990, 4: 1017-26. PMID: 2284004, DOI: 10.1210/mend-4-7-1017.Peer-Reviewed Original ResearchConceptsGH4C1 cellsEpidermal growth factorPRL synthesisGrowth factorPreferential increaseCombination of estradiolRegulated pathwayRat pituitary tumor cellsIntracellular PRLPituitary tumor cellsBasal releasePRL releaseIntracellular proinsulinSame time courseHormone treatmentPRL storageTumor cellsProinsulin immunoreactivityMRNA levelsPRLInsulinSame peak heightHormoneProinsulinTreatmentThapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells
Law G, Pachter J, Thastrup O, Hanley M, Dannies P. Thapsigargin, but not caffeine, blocks the ability of thyrotropin-releasing hormone to release Ca2+ from an intracellular store in GH4C1 pituitary cells. Biochemical Journal 1990, 267: 359-364. PMID: 1692207, PMCID: PMC1131296, DOI: 10.1042/bj2670359.Peer-Reviewed Original ResearchMeSH Keywords3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsCaffeineCalciumCell LineInositol PhosphatesKineticsNimodipinePituitary NeoplasmsPlants, MedicinalProlactinTerpenesThapsigarginThyrotropin-Releasing HormoneTumor Cells, CulturedConceptsThyrotropin-releasing hormoneGH4C1 pituitary cellsPituitary cellsIntracellular storesGH4C1 cellsAbility of TRHBay K 8644Cytosolic free Ca2Action of thapsigarginInsP3-sensitive storesSustained elevationChannel blockersReceptor levelsTRH stimulationExtracellular Ca2Intracellular Ca2Transient increaseFree Ca2ThapsigarginSubsequent spikesHormoneCell typesCa2CellsEfflux
1985
Prolactin
Dannies P. Prolactin. 1985, 159-174. DOI: 10.1007/978-1-4684-7018-5_7.Peer-Reviewed Original ResearchSecretion of proteinsRegulation of osmolarityCell biologistsMolecular biologistsHormone actionProlactin productionBiologistsRegulationAnterior pituitary glandVariety of effectsUseful modelHuman growth hormoneHormone productionHuman studiesPituitary glandGrowth hormoneHuman prolactinProteinProlactinReproductionProductionHormoneImportant toolLarge number
1984
Unresponsiveness of GH cells to cyclo(histidyl-proline), a metabolite of thyrotropin releasing hormone
Battaini F, Dannies P, Peterkofsky A. Unresponsiveness of GH cells to cyclo(histidyl-proline), a metabolite of thyrotropin releasing hormone. Life Sciences 1984, 35: 2519-2527. PMID: 6096658, DOI: 10.1016/0024-3205(84)90438-7.Peer-Reviewed Original Research
1976
Release and synthesis of prolactin by rat pituitary cell strains are regulated independently by thyrotropin-releasing hormone
DANNIES P, TASJIAN A. Release and synthesis of prolactin by rat pituitary cell strains are regulated independently by thyrotropin-releasing hormone. Nature 1976, 261: 707-710. PMID: 180421, DOI: 10.1038/261707a0.Peer-Reviewed Original Research
1973
Effects of Thyrotropin-releasing Hormone and Hydrocortisone on Synthesis and Degradation of Prolactin in a Rat Pituitary Cell Strain
Dannies P, Tashjian A. Effects of Thyrotropin-releasing Hormone and Hydrocortisone on Synthesis and Degradation of Prolactin in a Rat Pituitary Cell Strain. Journal Of Biological Chemistry 1973, 248: 6174-6179. PMID: 4199262, DOI: 10.1016/s0021-9258(19)43524-2.Peer-Reviewed Original ResearchConceptsSynthesis of prolactinProlactin accumulationThyrotropin-releasing hormoneHydrocortisone resultsEffect of thyrotropinLong-term effectsPituitary cellsGH cellsProlactinDegradation of prolactinHormoneTerm effectsHydrocortisoneIntracellular poolDecreased accumulationClonal strainsCell strainsRadioactive leucineSpecific immunoprecipitationCellsHoursTreatmentDaysLeucineCulture mediumCHAPTER 1 Growth Hormone and Prolactin from Rat Pituitary Tumor Cells11Preparation of this review and the results of original experiments described were supported in part by a research grant from the USPHS (AM 11011). P. S. Dannies is a Postdoctoral Research Fellow of The Arthritis Foundation.
Dannies P, Tashjian A. CHAPTER 1 Growth Hormone and Prolactin from Rat Pituitary Tumor Cells11Preparation of this review and the results of original experiments described were supported in part by a research grant from the USPHS (AM 11011). P. S. Dannies is a Postdoctoral Research Fellow of The Arthritis Foundation. 1973, 561-569. DOI: 10.1016/b978-0-12-427150-0.50128-5.Peer-Reviewed Original ResearchGrowth hormoneRat pituitary tumor cellsPituitary tumor cellsPituitary cellsTumor cellsNormal pituitary cellsMechanism of actionArthritis FoundationIntact animalsComplement fixationProlactinHormoneCell populationsHomogeneous cell populationClonal strainsUseful modelCellsVariety of factorsCell homogenatesMicrocomplement fixationFixationCulture medium