2024
Harnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer
Lindsay M, de Oliveira S, Sciacca K, Lindvall C, Ananth P. Harnessing Natural Language Processing to Assess Quality of End-of-Life Care for Children With Cancer. JCO Clinical Cancer Informatics 2024, 8: e2400134. PMID: 39265122, PMCID: PMC11407740, DOI: 10.1200/cci.24.00134.Peer-Reviewed Original ResearchConceptsEnd-of-life carePalliative care consultationGoals of careLocation of deathProportion of decedentsDocumented discussionCare consultationEvidence-based quality measuresMeasure quality of careGold standard manual chart reviewQuality measuresQuality of careEnd of lifeContent of clinical notesLife-sustaining treatmentEnd-of-lifeManual chart reviewCancer decedentsEfficient quality measureCohort of childrenAssess qualityMulti-center researchQuality improvementMeasure qualityCare
2023
Parent Priorities in End-of-Life Care for Children With Cancer
Ananth P, Lindsay M, Mun S, McCollum S, Shabanova V, de Oliveira S, Pitafi S, Kirch R, Ma X, Gross C, Boyden J, Feudtner C, Wolfe J. Parent Priorities in End-of-Life Care for Children With Cancer. JAMA Network Open 2023, 6: e2313503. PMID: 37184834, PMCID: PMC10878399, DOI: 10.1001/jamanetworkopen.2023.13503.Peer-Reviewed Original ResearchMeasuring Pediatric Palliative Care Quality: Challenges and Opportunities
Boyden J, Bogetz J, Johnston E, Thienprayoon R, Williams C, McNeil M, Patneaude A, Widger K, Rosenberg A, Ananth P. Measuring Pediatric Palliative Care Quality: Challenges and Opportunities. Journal Of Pain And Symptom Management 2023, 65: e483-e495. PMID: 36736860, PMCID: PMC10106436, DOI: 10.1016/j.jpainsymman.2023.01.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Development of Primary Palliative Care End-of-Life Quality Measures: A Modified Delphi Process.
Bogetz J, Johnston E, Thienprayoon R, Patneaude A, Ananth P, Rosenberg A. Development of Primary Palliative Care End-of-Life Quality Measures: A Modified Delphi Process. Pediatrics 2022, 150 PMID: 36437228, DOI: 10.1542/peds.2022-058241.Peer-Reviewed Original ResearchConceptsComplex chronic conditionsEOL quality measuresPediatric palliative careEnd of lifeElectronic health recordsHealth care utilizationMultidisciplinary expert panelHigh-quality pediatric palliative careManual chart reviewQuality improvement initiativesModified Delphi processChart reviewCare utilizationSymptom managementPalliative careChronic conditionsIllness trajectoryPediatric measuresLife quality measuresDelphi processHealth recordsExpert panelImprovement initiativesQuality measuresInterprofessional servicesCharting a path to high‐quality end‐of‐life care for children with cancer
Ananth P, Wolfe J, Johnston EE. Charting a path to high‐quality end‐of‐life care for children with cancer. Cancer 2022, 128: 3586-3592. PMID: 36006762, PMCID: PMC9530011, DOI: 10.1002/cncr.34419.Commentaries, Editorials and LettersEnd‐of‐life care quality for children with cancer who receive palliative care
Ananth P, Lindsay M, Nye R, Mun S, Feudtner C, Wolfe J. End‐of‐life care quality for children with cancer who receive palliative care. Pediatric Blood & Cancer 2022, 69: e29841. PMID: 35686746, PMCID: PMC10498672, DOI: 10.1002/pbc.29841.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionCare unit admissionLife care qualityDistressing symptomsCancer decedentsEnd of lifeUnit admissionMechanical ventilationCare qualityPalliative Care DatabaseDays of lifeLower household incomeAnnual household incomeHospice enrollmentHospital admissionMultivariable analysisPatient factorsUnivariable analysisPalliative careCare databaseHospice servicesLower oddsResearch DatabaseCancer typesHospital servicesSurvey of Pediatric Palliative Care Quality Improvement Training, Activities, and Barriers
Bogetz JF, Johnston E, Ananth P, Patneaude A, Workgroup T, Thienprayoon R, Rosenberg A. Survey of Pediatric Palliative Care Quality Improvement Training, Activities, and Barriers. Journal Of Pain And Symptom Management 2022, 64: e123-e131. PMID: 35577143, DOI: 10.1016/j.jpainsymman.2022.04.182.Peer-Reviewed Original ResearchConceptsPediatric palliative careQI activitiesHigh-quality pediatric palliative careQI effortsQI workPediatrics Task ForceHalf of participantsQuality improvement activitiesPalliative careQuality improvement trainingEducation/trainingSerious illnessImprovement NetworkElectronic surveyQI trainingOne-thirdHours totalTwo-thirdsCliniciansClinical disciplinesOne-quarterResearch NetworkTask ForceDedicated staffStandardized measures
2021
Perspectives of pediatric oncologists and palliative care physicians on the therapeutic use of cannabis in children with cancer
Oberoi S, Protudjer JLP, Rapoport A, Rassekh SR, Crooks B, Siden H, Decker K, Ananth P, Chapman S, Balneaves LG, Vanan MI, Kelly LE. Perspectives of pediatric oncologists and palliative care physicians on the therapeutic use of cannabis in children with cancer. Cancer Reports 2021, 5: e1551. PMID: 34672127, PMCID: PMC9458513, DOI: 10.1002/cnr2.1551.Peer-Reviewed Original ResearchConceptsPalliative care physiciansCare physiciansPediatric oncologistsCannabis-related researchPediatric oncology patientsManagement of nauseaMost pediatric oncologistsSafety of cannabisPotential roleUse of cannabisSymptom controlPoor appetiteSymptom reliefChronic painOncology patientsPediatric oncologySide effectsMedical cannabisOncologistsTherapeutic useAnticancer effectsPhysiciansCancerSurvey domainsCannabisRefining Patient-Centered Measures of End-of-Life Care Quality for Children With Cancer
Ananth P, Mun S, Reffat N, Kang SJ, Pitafi S, Ma X, Gross CP, Wolfe J. Refining Patient-Centered Measures of End-of-Life Care Quality for Children With Cancer. JCO Oncology Practice 2021, 18: e372-e382. PMID: 34613797, PMCID: PMC8932486, DOI: 10.1200/op.21.00447.Peer-Reviewed Original ResearchConceptsMedian importance scoresPalliative care consultationHealth care usePatient-reported outcomesCross-sectional electronic surveyLife care qualityPatient-centered measuresHealth care teamHealth care professionalsHealth care resourcesCandidate quality measuresCancer stakeholdersSymptom screeningCare consultationsCare useCare teamLife careCare professionalsPatient needsCare resourcesFamily stakeholdersCare qualityMedian scoreQuality measuresElectronic surveyReenvisioning End-of-Life Care Quality Measurement for Adolescents and Young Adults With Cancer—Novel Patient-Centered Indicators and Approaches
Ananth P. Reenvisioning End-of-Life Care Quality Measurement for Adolescents and Young Adults With Cancer—Novel Patient-Centered Indicators and Approaches. JAMA Network Open 2021, 4: e2122323. PMID: 34424309, DOI: 10.1001/jamanetworkopen.2021.22323.Commentaries, Editorials and LettersSociodemographic and hospital‐based predictors of intense end‐of‐life care among children, adolescents, and young adults with hematologic malignancies
Mun S, Wang R, Ma X, Ananth P. Sociodemographic and hospital‐based predictors of intense end‐of‐life care among children, adolescents, and young adults with hematologic malignancies. Cancer 2021, 127: 3817-3824. PMID: 34185881, PMCID: PMC8478813, DOI: 10.1002/cncr.33764.Peer-Reviewed Original ResearchConceptsHematologic malignanciesYoung adultsLife careMultivariable logistic regression modelCancer-directed treatmentPremier Healthcare DatabaseRetrospective cohort studyEmergency department visitsIntensive care unitHigh-intensity endDays of lifeMajority of childrenLogistic regression modelsIntravenous chemotherapyTracheostomy placementCohort studyDepartment visitsCare unitMechanical ventilationHospital characteristicsMultivariable modelCardiopulmonary resuscitationType of insuranceHealthcare databasesMalignancyA Stakeholder-Driven Qualitative Study to Define High Quality End-of-Life Care for Children With Cancer
Ananth P, Mun S, Reffat N, Li R, Sedghi T, Avery M, Snaman J, Gross CP, Ma X, Wolfe J. A Stakeholder-Driven Qualitative Study to Define High Quality End-of-Life Care for Children With Cancer. Journal Of Pain And Symptom Management 2021, 62: 492-502. PMID: 33556497, PMCID: PMC8339188, DOI: 10.1016/j.jpainsymman.2021.01.134.Peer-Reviewed Original ResearchConceptsHigh-quality endQuality EOLCAdvanced cancerSymptom managementLife careQuality endLocation of deathMulticenter qualitative studyAvoidance of hospitalizationPerson-centered measuresCancer stakeholdersEnd of lifeSupportive careMechanical ventilationParents of childrenEmergency departmentInterdisciplinary careInterdisciplinary healthcare professionalsCardiopulmonary resuscitationHospice careQualitative studyCancerHealthcare professionalsFamily preferencesYoung adults
2020
Patterns of medication use at end of life by pediatric inpatients with cancer
Prozora S, Shabanova V, Ananth P, Pashankar F, Kupfer GM, Massaro SA, Davidoff AJ. Patterns of medication use at end of life by pediatric inpatients with cancer. Pediatric Blood & Cancer 2020, 68: e28837. PMID: 33306281, DOI: 10.1002/pbc.28837.Peer-Reviewed Original ResearchConceptsMedication usePediatric inpatientsVizient Clinical Database/Resource ManagerHematopoietic stem cell transplantLife-sustaining medicationsMedication utilization patternsSymptom management medicationsUse of opioidsStem cell transplantIntensive care unitLength of stayAcademic medical centerResource use dataLast weekWarrants further studyEvidence-based approachVasopressor useEnd of lifeCare unitCell transplantMedication categoriesResuscitate statusRetrospective studyMalignancy typeOdds ratioParent and patient perceptions of medical marijuana in the childhood cancer context
Ananth P, Revette A, Reed‐Weston A, Das P, Wolfe J. Parent and patient perceptions of medical marijuana in the childhood cancer context. Pediatric Blood & Cancer 2020, 68: e28830. PMID: 33258215, DOI: 10.1002/pbc.28830.Peer-Reviewed Original ResearchConceptsParents of childrenInductive coding approachesPsychological effectsGreater side effect profileParents' perceptionsPediatric cancer careMedical marijuanaParticipantsLack of researchParentsMM useRobust clinical trial dataPerceptionSupportive care medicationsCancer-directed therapyFuture research initiativesSide effect profileYoung adult patientsRelief of nauseaComprehensive cancer centerMarijuanaClinical trial dataFramework analysisAYAsQualitative studyParent Perceptions of Team-Delivered Care for Children With Advanced Cancer: A Report From the PediQUEST Study
Feraco AM, Ananth P, Dussel V, Al-Sayegh H, Ma C, Rosenberg AR, Feudtner C, Wolfe J. Parent Perceptions of Team-Delivered Care for Children With Advanced Cancer: A Report From the PediQUEST Study. Journal Of Pain And Symptom Management 2020, 60: 811-817. PMID: 32450115, PMCID: PMC7508972, DOI: 10.1016/j.jpainsymman.2020.05.019.Peer-Reviewed Original ResearchConceptsAdvanced cancerCare teamIndividual cliniciansExact testCare qualityRatings of careFisher's exact testHealth care teamSymptom management trialsParents' perceptionsChildhood cancer careCross-sectional surveyOne-third reportInterprofessional health care teamsCare of childrenClinician typePediQUEST studyPrimary outcomeParents of childrenCancer careAssociated FactorsRefractory cancerChild's oncologistExcellent careCancer
2018
Provider Perspectives on Use of Medical Marijuana in Children With Cancer
Ananth P, Ma C, Al-Sayegh H, Kroon L, Klein V, Wharton C, Hallez E, Braun I, Michelson K, Rosenberg AR, London W, Wolfe J. Provider Perspectives on Use of Medical Marijuana in Children With Cancer. Pediatrics 2018, 141: e20170559. PMID: 29233937, PMCID: PMC5744275, DOI: 10.1542/peds.2017-0559.Peer-Reviewed Original ResearchConceptsPediatric oncology providersMedical marijuanaOncology providersMM useProvider perspectivesCancer-directed therapyPercent of providersCross-sectional surveyLogistic regression modelsWilcoxon rank testSupportive careMedian ageOral formulationMM practiceSerious illnessMost providersGroup comparisonsCancerPrevious monthRank testState-specific regulationsChildrenRegression modelsImportant barriersGreatest barrier
2017
Medical marijuana in pediatric oncology: A review of the evidence and implications for practice
Ananth P, Reed‐Weston A, Wolfe J. Medical marijuana in pediatric oncology: A review of the evidence and implications for practice. Pediatric Blood & Cancer 2017, 65 PMID: 28926679, DOI: 10.1002/pbc.26826.Peer-Reviewed Original ResearchConceptsMedical marijuanaPediatric oncologyCancer-related symptomsPediatric oncology patientsSupportive care agentsMechanism of actionSupportive carePediatric patientsOncology patientsSerious illnessCare agentsPatientsOncologyMarijuanaPotential benefitsPurported benefitsFuture investigationsReviewSymptomsIllnessCancerCareInfluence of early phase clinical trial enrollment on patterns of end‐of‐life care for children with advanced cancer
Ananth P, Monsereenusorn C, Ma C, Al‐Sayegh H, Wolfe J, Rodriguez‐Galindo C. Influence of early phase clinical trial enrollment on patterns of end‐of‐life care for children with advanced cancer. Pediatric Blood & Cancer 2017, 65 PMID: 28771913, DOI: 10.1002/pbc.26748.Peer-Reviewed Original ResearchConceptsEarly phase clinical trialsTrial enrollmentAdvanced cancerHealthcare utilizationLife careRetrospective cohort studyPediatric oncology patientsClinical trial enrollmentPhase clinical trialsPatterns of endNeP patientsBaseline characteristicsCohort studyOncology patientsEP patientsPPC consultationClinical trialsCare receiptPatientsCancerEnrollmentCareFuture studiesChildrenEOLCTrends in Hospital Utilization and Costs among Pediatric Palliative Care Recipients
Ananth P, Melvin P, Berry JG, Wolfe J. Trends in Hospital Utilization and Costs among Pediatric Palliative Care Recipients. Journal Of Palliative Medicine 2017, 20: 946-953. PMID: 28453361, DOI: 10.1089/jpm.2016.0496.Peer-Reviewed Original ResearchConceptsPediatric palliative carePPC consultationED visitsHospital admissionHospital costsHospital utilizationAnnual hospital admission rateIntensive care unit usePalliative care recipientsPercent of patientsRetrospective cohort studyAnnual ED visitsEmergency department visitsHospital admission ratesQuaternary children's hospitalYears of agePPC involvementCohort studyDepartment visitsMedian ageED useSingle centerChildren's HospitalPalliative careIll children
2016
Liposomal doxorubicin: Effective treatment for pediatric desmoid fibromatosis
Ananth P, Werger A, Voss S, Rodriguez‐Galindo C, Janeway KA. Liposomal doxorubicin: Effective treatment for pediatric desmoid fibromatosis. Pediatric Blood & Cancer 2016, 64: e26375. PMID: 27905688, DOI: 10.1002/pbc.26375.Peer-Reviewed Original ResearchConceptsProgression-free intervalLiposomal doxorubicinDesmoid fibromatosisLonger progression-free intervalMedian progression-free intervalRetrospective case seriesImportant treatment optionClinical responseMedical therapyCase seriesTumor sizeTreatment optionsEffective treatmentFibromatosisTreatmentChildrenMedications