Featured Publications
TRIM5 is an innate immune sensor for the retrovirus capsid lattice
Pertel T, Hausmann S, Morger D, Züger S, Guerra J, Lascano J, Reinhard C, Santoni FA, Uchil PD, Chatel L, Bisiaux A, Albert ML, Strambio-De-Castillia C, Mothes W, Pizzato M, Grütter MG, Luban J. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. Nature 2011, 472: 361-365. PMID: 21512573, PMCID: PMC3081621, DOI: 10.1038/nature09976.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral Restriction FactorsCapsidCarrier ProteinsCell LineEnzyme ActivationHEK293 CellsHIV-1HumansImmunity, InnateLipopolysaccharidesMAP Kinase Kinase KinasesNF-kappa BProtein BindingReceptors, Pattern RecognitionRetroviridaeSignal TransductionTranscription Factor AP-1Transcription FactorsTripartite Motif ProteinsUbiquitinUbiquitin-Conjugating EnzymesUbiquitin-Protein Ligases
2015
TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling
Lascano J, Uchil PD, Mothes W, Luban J. TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling. Journal Of Virology 2015, 90: 308-316. PMID: 26468522, PMCID: PMC4702541, DOI: 10.1128/jvi.02496-15.Peer-Reviewed Original ResearchConceptsInnate immune signalingImmune signalingHIV-1 transductionHIV-1 restrictionAP-1 signalingViral nucleic acidsAP-1Retroviral capsid latticeAP-1 activationRestriction activityPast infectionProtein cyclophilin ARetrovirus infectionTRIM5Cyclophilin AActivity correlatesInfectionTRIM5 geneReverse transcriptionRetroviral transductionSignalingHost cell nucleusRetroviral capsidActivationTRIM family