Efficient and Functional Endothelial Repopulation of Whole Lung Organ Scaffolds
Le AV, Hatachi G, Beloiartsev A, Ghaedi M, Engler AJ, Baevova P, Niklason LE, Calle EA. Efficient and Functional Endothelial Repopulation of Whole Lung Organ Scaffolds. ACS Biomaterials Science & Engineering 2017, 3: 2000-2010. PMID: 33440555, DOI: 10.1021/acsbiomaterials.6b00784.Peer-Reviewed Original ResearchLong-term functionNative lungBarrier functionRat lungEndothelial cellsEndothelial nitric oxide synthaseLung microvascular endothelial cellsNitric oxide synthaseTissue plasminogen activatorVascular surface areaExposure of bloodMicrovascular endothelial cellsGas exchange functionRat lung microvascular endothelial cellsMechanical ventilationPulmonary arteryPulmonary vasculatureImproved barrier functionOxide synthaseVascular pressuresLung tissueFunctional endotheliumVE-cadherin gene expressionAntithrombotic substancesLung