1990
Neonatal seizure: magnetic resonance spectroscopic findings.
Young R, Petroff O. Neonatal seizure: magnetic resonance spectroscopic findings. Seminars In Perinatology 1990, 14: 238-47. PMID: 2196682.Peer-Reviewed Original ResearchNeonatal Excitotoxic Brain Injury
Young R, Petroff O, Novotny E, Wong M. Neonatal Excitotoxic Brain Injury. Developmental Neuroscience 1990, 12: 210-220. PMID: 2142073, DOI: 10.1159/000111850.Peer-Reviewed Original ResearchConceptsQuisqualic acidBrain injuryNeonatal excitotoxic brain injuryExcitotoxic brain injuryHypoxic-ischemic injuryNeonatal rat brainN-acetyl aspartateExcitotoxic damageNeuronal necrosisNeuropathologic examinationParoxysmal dischargesNeonatal ratsElectroencephalographic monitoringHilar areaRat brainMedial CA1Pathologic alterationsMetabolic alterationsParahippocampal regionPathological effectsGlutamate analogueInjuryPhysiologicUnique patternAlterations
1989
The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study
Young R, Chen B, Petroff O, Gore J, Cowan B, Novotny E, Wong M, Zuckerman K. The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study. Pediatric Research 1989, 25: 27-31. PMID: 2919113, DOI: 10.1203/00006450-198901000-00006.Peer-Reviewed Original ResearchConceptsBrain lactateBrain high-energy phosphatesArrest of seizuresFlurothyl-induced seizuresCerebral blood flowNormalization of EEGEffects of diazepamVivo 31P nuclear magnetic resonance spectroscopyHigh-energy phosphatesElectrographic seizuresNeonatal seizuresNeonatal dogsPostictal periodBrain pHBaseline valuesBlood flowBrain phosphocreatineMetabolic recoveryProlonged elevationSeizuresSustained increaseVivo 31PRapid returnDiazepamEnergy phosphates
1987
In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure
Young R, Cowan B, Petroff O, Novotny E, Dunham S, Briggs R. In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure. Annals Of Neurology 1987, 22: 622-628. PMID: 3426168, DOI: 10.1002/ana.410220511.Peer-Reviewed Original ResearchConceptsNeonatal seizuresBrain energy stateBicuculline-induced seizuresBrain glucose concentrationsCerebral blood flowBeta-hydroxybutyrate levelsBrain metabolic stateVivo 31P nuclear magnetic resonance spectroscopyBrain alanineAdenosine triphosphate levelsNeonatal dogsPhosphocreatine levelsSignificant elevationBlood flowSeizuresMagnetic resonance spectroscopyBrain extractsVivo 31PHypoglycemiaAdverse effectsTriphosphate levelsGlucose concentrationGreater declineFurther deteriorationMetabolic state
1986
High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid
Petroff O, Yu R, Ogino T. High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid. Journal Of Neurochemistry 1986, 47: 1270-1276. PMID: 3746301, DOI: 10.1111/j.1471-4159.1986.tb00750.x.Peer-Reviewed Original Research
1983
Cerebral metabolic studies in vivo by 31P NMR.
Prichard J, Alger J, Behar K, Petroff O, Shulman R. Cerebral metabolic studies in vivo by 31P NMR. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 2748-2751. PMID: 6573678, PMCID: PMC393905, DOI: 10.1073/pnas.80.9.2748.Peer-Reviewed Original ResearchConceptsStatus epilepticusCerebral metabolic studiesNitrous oxide analgesiaHypoxic hypoxiaMetabolic disturbancesCardiovascular functionInsulin shockEpilepticusHypoglycemiaLiving rabbitsCreatine kinaseMetabolic stressPhosphocreatine storesHypoxiaMetabolic studiesADP levelsATP levelsReversible decreaseSimilar changesPhosphocreatine poolBrainPhysiological variablesSurface coilAnalgesia