1990
Neonatal Excitotoxic Brain Injury
Young R, Petroff O, Novotny E, Wong M. Neonatal Excitotoxic Brain Injury. Developmental Neuroscience 1990, 12: 210-220. PMID: 2142073, DOI: 10.1159/000111850.Peer-Reviewed Original ResearchConceptsQuisqualic acidBrain injuryNeonatal excitotoxic brain injuryExcitotoxic brain injuryHypoxic-ischemic injuryNeonatal rat brainN-acetyl aspartateExcitotoxic damageNeuronal necrosisNeuropathologic examinationParoxysmal dischargesNeonatal ratsElectroencephalographic monitoringHilar areaRat brainMedial CA1Pathologic alterationsMetabolic alterationsParahippocampal regionPathological effectsGlutamate analogueInjuryPhysiologicUnique patternAlterations
1988
1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia
Petroff O, Young R, Cowan B, Novotny E. 1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia. Pediatric Neurology 1988, 4: 31-34. PMID: 3233106, DOI: 10.1016/0887-8994(88)90021-5.Peer-Reviewed Original ResearchConceptsHigh-energy phosphatesBrain high-energy phosphatesBrain energy stateHypoglycemic brain damageInsulin-induced hypoglycemiaExcitatory amino acidsHypoglycemic brain injuryBrain tissue injuryMagnetic resonance spectroscopy studyAdult experimental animalsBrain glucose contentNeonatal hypoglycemiaExcitatory neurotransmitterInhibitory neurotransmitterMechanisms of resistanceNeonatal dogsBrain damageBrain injuryBrain glutamateTissue injuryEnergy failureNeonatal animalsGABA concentrationExperimental animalsHypoglycemia