2023
Role of colectomy in the management of appendiceal tumors: a retrospective cohort study
Marks V, Kerekes D, Butensky S, Ahuja N, Johnson C, Turaga K, Khan S. Role of colectomy in the management of appendiceal tumors: a retrospective cohort study. BMC Gastroenterology 2023, 23: 398. PMID: 37978348, PMCID: PMC10655451, DOI: 10.1186/s12876-023-03019-4.Peer-Reviewed Original ResearchConceptsGoblet cell adenocarcinomaNon-mucinous adenocarcinomaRight hemicolectomyStage 2 diseaseNeuroendocrine neoplasmsTumor typesAppendiceal tumorsMucinous adenocarcinomaAppendiceal goblet cell adenocarcinomaRole of colectomyNational Cancer DatabasePostoperative hospital stayRetrospective cohort studyRisk-adjusted analysisRange of histologiesDifferent tumor typesConclusionsMost patientsHospital stayUnplanned readmissionCohort studySurgical treatmentHistologic typeSurgical outcomesCell adenocarcinomaCancer Database
2022
Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery
Bakkila BF, Kerekes D, Nunez-Smith M, Billingsley KG, Ahuja N, Wang K, Oladele C, Johnson CH, Khan SA. Evaluation of Racial Disparities in Quality of Care for Patients With Gastrointestinal Tract Cancer Treated With Surgery. JAMA Network Open 2022, 5: e225664. PMID: 35377425, PMCID: PMC8980937, DOI: 10.1001/jamanetworkopen.2022.5664.Peer-Reviewed Original ResearchConceptsGastrointestinal tract cancerNegative resection marginsTract cancerNegative surgical marginsBlack patientsAdequate lymphadenectomyWhite patientsQuality of careRacial disparitiesSurgical resectionResection marginsSurgical marginsSurgical careNational Cancer DatabaseRetrospective cohort studySite of cancerLonger median survivalHealth careStandard of careCommon age rangeSignificant racial disparitiesAdjuvant chemotherapyBiliary resectionAdjuvant therapyAdult patients
2020
Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival
Heller DR, Nicolson NG, Ahuja N, Khan S, Kunstman JW. Association of Treatment Inequity and Ancestry With Pancreatic Ductal Adenocarcinoma Survival. JAMA Surgery 2020, 155: e195047. PMID: 31800002, PMCID: PMC6902102, DOI: 10.1001/jamasurg.2019.5047.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaNational Cancer DatabaseWhite patientsBlack patientsAdvanced diseaseOverall survivalClinical parametersDisease stageCancer DatabaseSurgical proceduresMultivariable Cox proportional hazards regression modelingTreatment inequitiesCox proportional hazards regression modelingPancreatic ductal adenocarcinoma (PDAC) survivalUnadjusted median overall survivalYounger ageProportional hazards regression modelingMedian overall survivalModest survival advantageStage II diseaseNew cancer diagnosesLess chemotherapyResectable cancerCohort studyPrimary outcome
2018
Low Frequency of Lymph Node Metastases in Patients in the United States With Early-stage Gastric Cancers That Fulfill Japanese Endoscopic Resection Criteria
Hanada Y, Choi AY, Hwang JH, Draganov PV, Khanna L, Sethi A, Bartel MJ, Goel N, Abe S, De Latour RA, Park K, Melis M, Newman E, Hatzaras I, Reddy SS, Farma JM, Liu X, Schlachterman A, Kresak J, Trapp G, Ansari N, Schrope B, Lee JY, Dhall D, Lo S, Jamil LH, Burch M, Gaddam S, Gong Y, Del Portillo A, Tomizawa Y, Truong CD, Brewer Gutierrez OI, Montgomery E, Johnston FM, Duncan M, Canto M, Ahuja N, Lennon AM, Ngamruengphong S. Low Frequency of Lymph Node Metastases in Patients in the United States With Early-stage Gastric Cancers That Fulfill Japanese Endoscopic Resection Criteria. Clinical Gastroenterology And Hepatology 2018, 17: 1763-1769. PMID: 30471457, DOI: 10.1016/j.cgh.2018.11.031.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAged, 80 and overCarcinoma, Signet Ring CellEndoscopic Mucosal ResectionFemaleGastrectomyHumansJapanLymph NodesLymphatic MetastasisMaleMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasm StagingPractice Guidelines as TopicRetrospective StudiesStomach NeoplasmsTumor BurdenUnited StatesConceptsFrequency of lymphEarly gastric cancerEndoscopic resectionLymph node metastasisLymph nodesGastric cancerLymphovascular invasionNode metastasisGastric adenocarcinomaEarly gastric cancer lesionsEarly-stage gastric cancerEndoscopic resection criteriaLymph node dissectionTertiary care centerRisk of lymphRisk of metastasisGastric cancer lesionsDefinitive therapyNode dissectionResection criteriaSurgical resectionAsian patientsRetrospective studySubmucosal invasionRisk factorsEnsuring Equity, Diversity, and Inclusion in Academic Surgery
West MA, Hwang S, Maier RV, Ahuja N, Angelos P, Bass BL, Brasel KJ, Chen H, Davis KA, Eberlein TJ, Fong Y, Greenberg CC, Lillemoe KD, McCarthy MC, Michelassi F, Numann PJ, Parangi S, Reyes JD, Sanfey HA, Stain SC, Weigel RJ, Wren SM. Ensuring Equity, Diversity, and Inclusion in Academic Surgery. Annals Of Surgery 2018, 268: 403-407. PMID: 30004923, DOI: 10.1097/sla.0000000000002937.Peer-Reviewed Original Research
2017
The independent effect of cancer on outcomes: a potential limitation of surgical risk prediction
Leeds IL, Canner JK, Efron JE, Ahuja N, Haut ER, Wick EC, Johnston FM. The independent effect of cancer on outcomes: a potential limitation of surgical risk prediction. Journal Of Surgical Research 2017, 220: 402-409.e6. PMID: 28923559, PMCID: PMC5712450, DOI: 10.1016/j.jss.2017.08.039.Peer-Reviewed Original ResearchConceptsCancer patientsDiagnosis of cancerBenign diseaseCancer populationNational Surgical Quality Improvement Program 2005Chronic obstructive pulmonary diseaseSurgical risk modelsSurgical risk predictionObstructive pulmonary diseaseWorse surgical outcomesMalignant gastrointestinal diseasesOdds of deathHigh complication rateMultivariable logistic regressionParticipant Use FileRisk of deathPrimary procedure codeHigh mortality rateComplication rateSurgical complicationsIndependent predictorsMultiple complicationsPulmonary diseaseElective surgeryNoncancer patientsThe Future of Basic Science in Academic Surgery
Keswani SG, Moles CM, Morowitz M, Zeh H, Kuo JS, Levine MH, Cheng LS, Hackam DJ, Ahuja N, Goldstein AM. The Future of Basic Science in Academic Surgery. Annals Of Surgery 2017, 265: 1053-1059. PMID: 27643928, PMCID: PMC5450912, DOI: 10.1097/sla.0000000000002009.Peer-Reviewed Original ResearchCombination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study
Connolly RM, Li H, Jankowitz RC, Zhang Z, Rudek MA, Jeter SC, Slater SA, Powers P, Wolff AC, Fetting JH, Brufsky A, Piekarz R, Ahuja N, Laird PW, Shen H, Weisenberger DJ, Cope L, Herman JG, Somlo G, Garcia AA, Jones PA, Baylin SB, Davidson NE, Zahnow CA, Stearns V. Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study. Clinical Cancer Research 2017, 23: 2691-2701. PMID: 27979916, PMCID: PMC5457329, DOI: 10.1158/1078-0432.ccr-16-1729.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerObjective response rateCombination epigenetic therapyEstrogen receptorEndocrine therapyPrimary endpointPartial responseMulticenter phase II studyEpigenetic therapyAdditional partial responsesHormone-resistant diseasePhase II studyTime of progressionBreast cancer modelClin Cancer ResHistone deacetylase inhibitorsImportant therapeutic targetPosttreatment biopsiesTNBC cohortII studyBreast cancerDNA methyltransferase inhibitorTherapeutic targetResponse rateCancer model
2016
Gastric and small intestine gastrointestinal stromal tumors: Do outcomes differ?
Giuliano K, Nagarajan N, Canner J, Najafian A, Wolfgang C, Schneider E, Meyer C, Lennon AM, Johnston FM, Ahuja N. Gastric and small intestine gastrointestinal stromal tumors: Do outcomes differ? Journal Of Surgical Oncology 2016, 115: 351-357. PMID: 27885685, DOI: 10.1002/jso.24514.Peer-Reviewed Original ResearchConceptsSmall intestine gastrointestinal stromal tumorGastrointestinal stromal tumorsCause-specific mortalityGIST patientsDiagnosis of GISTCases of GISTLarge nation-wide studyGastric gastrointestinal stromal tumorsGastric GIST patientsCommon mesenchymal tumorsFive-year survivalApproval of imatinibNation-wide studySEER databaseStromal tumorsMesenchymal tumorsGastrointestinal tractAge 50PatientsSurvival analysisSimilar outcomesTumorsPrevious reportsFrequent useOutcomesPredictors of improved survival for patients with retroperitoneal sarcoma
Giuliano K, Nagarajan N, Canner JK, Wolfgang CL, Bivalacqua T, Terezakis S, Herman J, Schneider EB, Ahuja N. Predictors of improved survival for patients with retroperitoneal sarcoma. Surgery 2016, 160: 1628-1635. PMID: 27495850, DOI: 10.1016/j.surg.2016.05.041.Peer-Reviewed Original ResearchConceptsRetroperitoneal sarcomaMultivariable survival analysisSurvival analysisRetroperitoneal sarcoma patientsEnd Results (SEER) databaseOperative resectionImproved survivalLymph nodesSurvival benefitDistant metastasisHistologic typeResults databaseSarcoma patientsRare tumorCancer DatabaseLonger survivalPatientsSarcomaSurvivalParametric survival functionsLocal extensionFurther studiesHigh rateResectionRecurrenceUnderstanding the Barriers to Hiring and Promoting Women in Surgical Subspecialties
Valsangkar N, Fecher AM, Rozycki GS, Blanton C, Bell TM, Freischlag J, Ahuja N, Zimmers TA, Koniaris LG. Understanding the Barriers to Hiring and Promoting Women in Surgical Subspecialties. Journal Of The American College Of Surgeons 2016, 223: 387-398.e2. PMID: 27109779, DOI: 10.1016/j.jamcollsurg.2016.03.042.Peer-Reviewed Original ResearchConceptsCardiothoracic surgerySurgical facultyDepartment of SurgeryNIH fundingOverall median numberCertain subspecialtiesSurgical departmentSurgical oncologyMedian numberFraction of womenHigher NIH fundingPublications/citationsObserved lower numberSurgerySurgical subspecialtiesPotential disparitiesWomenDemographic characteristicsFunding detailsSubspecialtyFemale assistant professorsAssistant professor levelDivision chiefsDepartmentMore recent citations
2014
Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough?
Schneider EB, Ejaz A, Spolverato G, Hirose K, Makary MA, Wolfgang CL, Ahuja N, Weiss M, Pawlik TM. Hospital Volume and Patient Outcomes in Hepato-Pancreatico-Biliary Surgery: Is Assessing Differences in Mortality Enough? Journal Of Gastrointestinal Surgery 2014, 18: 2105-2115. PMID: 25297443, DOI: 10.1007/s11605-014-2619-9.Peer-Reviewed Original ResearchConceptsLength of stayHV hospitalsHV centersHospital volumeMajor complicationsLV centersBiliary surgeryHPB surgeryHospital patientsShorter median LOSMedian LOSComplex HPB surgeryHospital volume strataIncidence of complicationsPost-operative complicationsOverall mean ageHepato-PancreaticoLV hospitalsMedical comorbiditiesImpact of regionalizationMean ageBiliary proceduresHemorrhagic anemiaPatient outcomesIndex mortalityA comparison of open and minimally invasive surgery for hepatic and pancreatic resections using the nationwide inpatient sample
Ejaz A, Sachs T, He J, Spolverato G, Hirose K, Ahuja N, Wolfgang CL, Makary MA, Weiss M, Pawlik TM. A comparison of open and minimally invasive surgery for hepatic and pancreatic resections using the nationwide inpatient sample. Surgery 2014, 156: 538-547. PMID: 25017135, PMCID: PMC4316739, DOI: 10.1016/j.surg.2014.03.046.Peer-Reviewed Original ResearchConceptsMIS patientsInpatient outcomesLiver operationsNationwide Inpatient Sample databasePreoperative medical comorbiditiesIncidence of complicationsMultiple comorbid conditionsShorter median lengthAppropriate International ClassificationNationwide Inpatient SampleInvasive surgery techniquesDuration of stayHospital mortalityPostoperative morbidityHepatic resectionMedical comorbiditiesPancreatic resectionComorbid conditionsMIS groupMedian lengthOpen surgeryInpatient SampleOpen procedureRobotic assistInternational ClassificationRace-based differences in length of stay among patients undergoing pancreatoduodenectomy
Schneider EB, Calkins KL, Weiss MJ, Herman JM, Wolfgang CL, Makary MA, Ahuja N, Haider AH, Pawlik TM. Race-based differences in length of stay among patients undergoing pancreatoduodenectomy. Surgery 2014, 156: 528-537. PMID: 24973128, DOI: 10.1016/j.surg.2014.04.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack or African AmericanCross-Sectional StudiesFemaleGeneral SurgeryHealthcare DisparitiesHispanic or LatinoHospital MortalityHospitalsHumansLength of StayLogistic ModelsMaleMiddle AgedPancreaticoduodenectomyPostoperative ComplicationsRacial GroupsRetrospective StudiesUnited StatesWhite PeopleConceptsHigh-volume hospitalsHigh-volume surgeonsHispanic patientsRace-based differencesWhite patientsMedian annual surgeon volumeAnnual hospital volumeAnnual surgeon volumeOverall median LOSNationwide Inpatient SampleMultivariable logistic regressionLength of stayHospital mortalityHospital lengthMedian LOSHospital volumeOperative morbidityProvider volumeSurgeon volumeMedian lengthPD patientsInpatient SamplePatient racePancreatoduodenectomyEligible individualsAssessing the experience in complex hepatopancreatobiliary surgery among graduating chief residents: Is the operative experience enough?
Sachs TE, Ejaz A, Weiss M, Spolverato G, Ahuja N, Makary MA, Wolfgang CL, Hirose K, Pawlik TM. Assessing the experience in complex hepatopancreatobiliary surgery among graduating chief residents: Is the operative experience enough? Surgery 2014, 156: 385-393. PMID: 24953270, PMCID: PMC4316664, DOI: 10.1016/j.surg.2014.03.006.Peer-Reviewed Original ResearchConceptsMedian numberBiliary tractHPB casesHepatopancreatobiliary surgeryCase volumeMean numberPancreas casesChief yearChief residentsAccreditation CouncilGeneral surgery residentsHPB operationsMajor resectionAnatomic resectionSimple cholecystectomyPancreatic operationsPostgraduate year 1TA casesComplex liverPancreasOperative experienceResident operative autonomyLiverSame time periodSurgery residentsIs Minimally Invasive Colon Resection Better Than Traditional Approaches?: First Comprehensive National Examination With Propensity Score Matching
Juo YY, Hyder O, Haider AH, Camp M, Lidor A, Ahuja N. Is Minimally Invasive Colon Resection Better Than Traditional Approaches?: First Comprehensive National Examination With Propensity Score Matching. JAMA Surgery 2014, 149: 177-184. PMID: 24352653, PMCID: PMC4036435, DOI: 10.1001/jamasurg.2013.3660.Peer-Reviewed Original ResearchConceptsRoutine discharge ratesLaparoscopic colectomyOpen colectomyOstomy ratesColon resectionHospital mortalityComplication rateClinical outcomesUS Nationwide Inpatient Sample databaseNationwide Inpatient Sample databaseInvasive colon resectionPatients 21 yearsUS hospital dischargesShorter median lengthFavorable clinical outcomeLow complication rateLength of stayMost clinical outcomesOverall hospitalization costsLower mortality rateElective colectomyPerioperative outcomesDischarge dispositionHospital dischargeHospitalization costs
2013
Assessing Readmission After General, Vascular, and Thoracic Surgery Using ACS-NSQIP
Lucas DJ, Haider A, Haut E, Dodson R, Wolfgang CL, Ahuja N, Sweeney J, Pawlik TM. Assessing Readmission After General, Vascular, and Thoracic Surgery Using ACS-NSQIP. Annals Of Surgery 2013, 258: 430-439. PMID: 24022435, PMCID: PMC4623433, DOI: 10.1097/sla.0b013e3182a18fcc.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDatabases, FactualDecision Support TechniquesFemaleFollow-Up StudiesHealth Status IndicatorsHumansLength of StayMaleMiddle AgedMultivariate AnalysisPatient ReadmissionPostoperative ComplicationsRegression AnalysisRisk FactorsROC CurveSurgical Procedures, OperativeThoracic Surgical ProceduresUnited StatesVascular Surgical ProceduresConceptsASA classReadmission ratesThoracic surgerySurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramInteger-based scoreMedian American SocietyStay 10 daysMedian patient ageRisk of readmissionHigher readmission ratesQuality Improvement ProgramAnesthesiologists classInpatient complicationsMedian LOSPatient agePatient characteristicsNonelective surgeryUpper gastrointestinalACS-NSQIPReadmission riskRisk factorsReadmissionAmerican College
2010
Disparity in limb-salvage surgery among sarcoma patients
Downing S, Ahuja N, Oyetunji TA, Chang D, Frederick WA. Disparity in limb-salvage surgery among sarcoma patients. The American Journal Of Surgery 2010, 199: 549-553. PMID: 20359572, DOI: 10.1016/j.amjsurg.2009.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmputation, SurgicalAsianBlack or African AmericanFemaleHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHumansLimb SalvageLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyOdds RatioProportional Hazards ModelsRadiotherapy, AdjuvantSarcomaSEER ProgramUnited StatesWhite PeopleConceptsLimb-sparing proceduresLimb salvage surgeryLimb salvagePreoperative radiationSarcoma patientsAfrican AmericansEnd Results (SEER) databaseAfrican American patientsSpecific surgical proceduresWhite patientsResults databaseTreatment modalitiesAmerican patientsSurgical proceduresPatientsMultivariate analysisBivariate analysisLogistic regressionSalvageSurgerySurvivalRecent studiesPrevious studiesTumorsAmericansTeaching Hospital Status and Operative Mortality in the United States: Tipping Point in the Volume-Outcome Relationship Following Colon Resections?
Hayanga AJ, Mukherjee D, Chang D, Kaiser H, Lee T, Gearhart S, Ahuja N, Freischlag J. Teaching Hospital Status and Operative Mortality in the United States: Tipping Point in the Volume-Outcome Relationship Following Colon Resections? JAMA Surgery 2010, 145: 346-350. PMID: 20404284, PMCID: PMC4036455, DOI: 10.1001/archsurg.2010.24.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleLength of stayVolume-outcome relationshipColon resectionTeaching hospitalBenign diseaseOperative mortalityMean LOSColorectal surgery fellowshipsOdds of deathVolume-outcome effectRetrospective data analysisFederal poverty levelArea Resource FileComorbidity scoreSurgical resectionColon surgeryHospital covariatesNinth RevisionInpatient SampleInsurance statusPatient covariatesSurgeon characteristicsTH statusHospital status
2009
Variations in Referral Patterns to High-Volume Centers for Pancreatic Cancer
Chang DC, Zhang Y, Mukherjee D, Wolfgang CL, Schulick RD, Cameron JL, Ahuja N. Variations in Referral Patterns to High-Volume Centers for Pancreatic Cancer. Journal Of The American College Of Surgeons 2009, 209: 720-726. PMID: 19959040, PMCID: PMC4036485, DOI: 10.1016/j.jamcollsurg.2009.09.011.Peer-Reviewed Original ResearchConceptsHigh-volume centersHigh-volume hospitalsNationwide Inpatient SamplePancreatic cancer patientsArea Resource FilePancreatic resectionCancer patientsInpatient SamplePancreatic cancerRadiation oncologistsCharlson Comorbidity Index scoreComorbidity Index scoreOdds of referralPrimary outcome variableResource FileCommunity poverty levelCalendar yearPatient ageOverall referralsReferral patternsVolume centersInsurance statusPrimary diagnosisInclusion criteriaRetrospective analysis