2023
Comment on “Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans”
Colburn A, Stachenfeld N. Comment on “Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans”. Journal Of Applied Physiology 2023, 135: 485-486. PMID: 37541850, DOI: 10.1152/japplphysiol.00335.2023.Peer-Reviewed Original Research
2022
Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis
Dillon GA, Stanhewicz AE, Serviente C, Flores VA, Stachenfeld N, Alexander LM. Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis. Microvascular Research 2022, 144: 104421. PMID: 35970408, PMCID: PMC9527706, DOI: 10.1016/j.mvr.2022.104421.Peer-Reviewed Original ResearchConceptsEndothelium-dependent vasodilationLaser Doppler fluxEndothelial functionCardiovascular diseaseOral atorvastatinExerts potent anti-inflammatory effectsEndothelium-dependent agonist acetylcholineShort-term statin administrationPotent anti-inflammatory effectsIntradermal microdialysis perfusionNO-dependent dilationImpaired endothelial functionMicrovascular endothelial functionCutaneous microvascular functionCutaneous vascular conductanceAnti-inflammatory effectsNO-dependent vasodilationNO synthase inhibitorDose-response curveStatin therapyAdjunctive therapyAtorvastatin treatmentCVD riskEndothelial dysfunctionStatin administration
2019
Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor
Usselman CW, Yarovinsky T, Steele FE, Leone CA, Taylor HS, Bender JR, Stachenfeld NS. Androgens drive microvascular endothelial dysfunction in women with polycystic ovary syndrome: role of the endothelin B receptor. The Journal Of Physiology 2019, 597: 2853-2865. PMID: 30847930, DOI: 10.1113/jp277756.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogensCardiovascular DiseasesDihydrotestosteroneEndothelin-1Endothelium, VascularEstrogensEthinyl EstradiolFemaleGlucose Tolerance TestHumansMicrovesselsNitric OxideObesityPolycystic Ovary SyndromeReceptor, Endothelin BSkinVascular Endothelial Growth Factor AVasodilationYoung AdultConceptsPolycystic ovary syndromeCardiovascular dysfunctionEndothelial dysfunctionOvary syndromeEndothelin-1Endothelial functionNO productionAndrogen receptor-dependent mannerEndothelin-B receptor subtypeCardiovascular risk factorsMicrovascular endothelial dysfunctionMicrovascular endothelial functionCutaneous vascular conductanceB receptor subtypesEndothelin B receptorLaser Doppler flowmetryNitric oxide inhibitionReceptor-dependent mannerEndothelial cell NO productionDose-response curveVasodilating responsePCOS subjectsLean womenObese womenVascular conductance
2015
Sex hormone effects on autonomic mechanisms of thermoregulation in humans
Charkoudian N, Stachenfeld N. Sex hormone effects on autonomic mechanisms of thermoregulation in humans. Autonomic Neuroscience 2015, 196: 75-80. PMID: 26674572, DOI: 10.1016/j.autneu.2015.11.004.ChaptersConceptsAutonomic mechanismsReproductive hormonesBody temperatureCentral autonomic nucleusHeat dissipation responsePolycystic ovary syndromeFemale reproductive hormonesPeripheral blood vesselsInfluence of progesteroneSkin blood flowAutonomic nucleiOvary syndromePeripheral effectsMenstrual cycleHormone levelsBlood flowHormone effectsLow body temperatureBlood vesselsEstrogenHigh body temperatureRecent evidenceMenopauseProgesteroneThermoregulatory responses
2014
The Interrelationship of Research in the Laboratory and the Field to Assess Hydration Status and Determine Mechanisms Involved in Water Regulation During Physical Activity
Stachenfeld NS. The Interrelationship of Research in the Laboratory and the Field to Assess Hydration Status and Determine Mechanisms Involved in Water Regulation During Physical Activity. Sports Medicine 2014, 44: 97-104. PMID: 24791921, PMCID: PMC4008811, DOI: 10.1007/s40279-014-0155-0.Commentaries, Editorials and Letters
2011
Pharmacological curve fitting to analyze cutaneous adrenergic responses
Wenner MM, Wilson TE, Davis SL, Stachenfeld NS. Pharmacological curve fitting to analyze cutaneous adrenergic responses. Journal Of Applied Physiology 2011, 111: 1703-1709. PMID: 21868682, PMCID: PMC3233895, DOI: 10.1152/japplphysiol.00780.2011.Peer-Reviewed Original ResearchProgesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance
Wenner MM, Taylor HS, Stachenfeld NS. Progesterone enhances adrenergic control of skin blood flow in women with high but not low orthostatic tolerance. The Journal Of Physiology 2011, 589: 975-986. PMID: 21173076, PMCID: PMC3060374, DOI: 10.1113/jphysiol.2010.194563.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceHigh orthostatic toleranceOrthostatic toleranceAdrenergic responseAdrenergic responsivenessNitric oxide synthase inhibitor NG-monomethylEndogenous sex hormone productionSynthase inhibitor NG-monomethylSkin blood flow responseBlood flow responseInhibitor NG-monomethylSex hormone productionFemale sex hormonesLower body negative pressure testSkin blood flowGnRH antagonistProgesterone administrationOrthostatic intoleranceNG-monomethylPeripheral αMicrodialysis infusionSex hormonesCyclooxygenase pathwayHT womenAdrenergic control
1997
Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia
Haskell A, Nadel E, Stachenfeld N, Nagashima K, Mack G. Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia. Journal Of Applied Physiology 1997, 83: 407-413. PMID: 9262434, DOI: 10.1152/jappl.1997.83.2.407.Peer-Reviewed Original ResearchConceptsCapillary filtration coefficientTranscapillary escape rateLeg musclesUpright cycle ergometer exerciseVascular spaceTranscapillary forcesInterstitial fluid hydrostatic pressureCycle ergometer exercisePlasma albumin concentrationPlasma colloid osmotic pressureExercise-induced hypervolemiaColloid osmotic pressureErgometer exerciseIntense exerciseTotal protein concentrationFluid hydrostatic pressureAlbumin concentrationTERalbMuscleFiltration coefficientExerciseActive tissuesAlbuminLegProtein concentration