Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice
Shi Z, Bamford IJ, McKinley JW, Devi SPS, Vahedipour A, Bamford NS. Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice. Brain Sciences 2020, 10: 903. PMID: 33255421, PMCID: PMC7760026, DOI: 10.3390/brainsci10120903.Peer-Reviewed Original ResearchL-DOPA-induced dyskinesiaL-DOPAStriatal acetylcholineDA deficiencyMovement disordersDA availabilityHypokinetic movement disordersStriatal cholinergic interneuronsHyperkinetic movement disordersDopa decarboxylase inhibitorElectrophysiological experimentsOpen field testingStriatal ChIsParkinsonian miceCholinergic interneuronsMotor dysfunctionTherapeutic optionsMotor hyperactivityParadoxical riseDA ratioMotor functionDecarboxylase inhibitorDopamine insufficiencyΒ-ARsΒ-AR