2023
Exome Sequencing of 1429 Patients with Thoracic Aortic Disease at the Yale Aortic Institute: what Have We Learned?
Ziganshin B, Zafar M, Elefteriades J. Exome Sequencing of 1429 Patients with Thoracic Aortic Disease at the Yale Aortic Institute: what Have We Learned? Aorta 2023, 11: 1-18. DOI: 10.1055/s-0044-1787954.Peer-Reviewed Original Research
2022
Rapid growth of thoracic aortic aneurysm: Reality or myth?
Sonsino A, Ellauzi H, Ziganshin BA, Zafar MA, Elefteriades JA. Rapid growth of thoracic aortic aneurysm: Reality or myth? Journal Of Thoracic And Cardiovascular Surgery 2022, 167: 1206-1213. PMID: 36028356, DOI: 10.1016/j.jtcvs.2022.06.021.Peer-Reviewed Original ResearchRapid aortic growthAortic growthAortic growth rateProphylactic surgical interventionThoracic aortic aneurysmPrompt surgeryInoperable patientsAortic diseaseSurgical interventionAortic measurementsAortic aneurysmPositivity ratePatientsAortaExperienced cliniciansGenetic findingsAortic imagesAneurysmsAmerican AssociationPotential sourceSurgeryAscendingCliniciansDiseaseSurvivorsAortic gene dictionary in the precision medicine era—update from the Aortic Institute at Yale New Haven
Papanikolaou D, Zafar MA, Ziganshin BA, Elefteriades JA. Aortic gene dictionary in the precision medicine era—update from the Aortic Institute at Yale New Haven. Indian Journal Of Thoracic And Cardiovascular Surgery 2022, 38: 14-23. PMID: 35463698, PMCID: PMC8980985, DOI: 10.1007/s12055-021-01308-9.Peer-Reviewed Original Research
2021
Simple Hepatic Cysts as Markers of Thoracic Aortic Disease
C K, BA Z, MA Z, J B, J E. Simple Hepatic Cysts as Markers of Thoracic Aortic Disease. Journal Of Disease Markers 2021, 6 DOI: 10.26420/jdismarkers.2021.1043.Peer-Reviewed Original ResearchThoracic aortic diseaseSimple hepatic cystsBovine aortic archBicuspid aortic valveSimple renal cystsPositive family historyMost patientsAortic diseaseHepatic cystsRetrospective studyAortic aneurysmAortic archAortic valveClinical markersHospital patientsFamily historyRenal cystsTAD patientsControl groupPatientsAneurysmsPrevalenceCystsDiseaseInterstage mortality in two‐stage elephant trunk surgery
Saeyeldin A, Gryaznov AA, Zafar MA, Wu J, Mukherjee S, Vallabhajosyula P, Ziganshin BA, Elefteriades JA. Interstage mortality in two‐stage elephant trunk surgery. Journal Of Cardiac Surgery 2021, 36: 1882-1891. PMID: 33634489, DOI: 10.1111/jocs.15441.Peer-Reviewed Original ResearchConceptsExtensive thoracic aortic aneurysmThoracic aortic aneurysmInterstage intervalStage IIET procedureStage II procedureHospital mortalityInterstage mortalityMega aortaTrunk surgeryAortic ruptureOverall mortalitySingle surgeonAortic diseasePatient groupAortic aneurysmPatientsStage IMortalityCumulative mortalityI procedureInterval periodRupturePrior studiesSafetyIs Aortic Z-score an Appropriate Index of Beneficial Drug Effect in Clinical Trials in Aortic Aneurysm Disease?
Elkinany S, Weismann C, Curtis A, Smith T, Zafar MA, Breen T, Li Y, Tranquilli M, Rizzo JA, Mukherjee SK, Ziganshin BA, Elefteriades JA. Is Aortic Z-score an Appropriate Index of Beneficial Drug Effect in Clinical Trials in Aortic Aneurysm Disease? The American Journal Of Cardiology 2021, 143: 145-153. PMID: 33352210, DOI: 10.1016/j.amjcard.2020.12.025.Peer-Reviewed Original ResearchConceptsBody mass indexAortic Z-scoresZ-score decreaseBeneficial drug effectsZ-scoreMarfan patientsClinical trialsAneurysm diseaseDrug effectsChild's ageEcho examAortic dilation rateDecreased Z-scoreConnective tissue diseaseBody surface areaEffects of medicationAortic aneurysm diseaseClinical drug trialsMass indexTissue diseaseAortic diseaseAneurysmal pathologyDrug trialsInvestigational drugsSpontaneous decrease
2019
A systematic review and meta-analysis of isolated abdominal aortic dissection
Wu J, Zafar M, Qiu J, Huang Y, Chen Y, Yu C, Elefteriades JA. A systematic review and meta-analysis of isolated abdominal aortic dissection. Journal Of Vascular Surgery 2019, 70: 2046-2053.e6. PMID: 31204217, DOI: 10.1016/j.jvs.2019.04.467.Peer-Reviewed Original ResearchConceptsIsolated abdominal aortic dissectionType B aortic dissectionAbdominal aortic dissectionAortic dissectionB aortic dissectionPrevalent risk factorsRisk factorsAverage aortic diameterComplication-specific approachEndovascular aortic repairAbdominal painChest painLate mortalityAortic repairClinical characteristicsConservative managementBack painPooled prevalenceRenal arteryAbdominal examinationAortic diameterAortic diseaseClinical symptomsCommon symptomsOpen surgeryFluoroquinolones and Aortic Diseases: Is There a Connection
Carino D, Zafar MA, Singh M, Ziganshin BA, Elefteriades JA. Fluoroquinolones and Aortic Diseases: Is There a Connection. Aorta 2019, 07: 035-041. PMID: 31529426, PMCID: PMC6748841, DOI: 10.1055/s-0039-1693468.Peer-Reviewed Original ResearchAortic diseaseAdverse effectsHigh tissue distributionThoracic aortic diseaseConsumption of fluoroquinolonesDifferent adverse effectsNumerous infectious diseasesAntibacterial coverageRetinal detachmentAortic aneurysmClasses of antibioticsInfectious diseasesDiseaseFluoroquinolonesTissue distributionCollagen degradationMolecular mechanismsPossible contributionDysglycemiaAneurysmsArrhythmiasPathogenesisDissectionAchillesSimple renal cysts and bovine aortic arch: markers for aortic disease
Brownstein AJ, Bin Mahmood SU, Saeyeldin A, Velasquez Mejia C, Zafar MA, Li Y, Rizzo JA, Dahl NK, Erben Y, Ziganshin BA, Elefteriades JA. Simple renal cysts and bovine aortic arch: markers for aortic disease. Open Heart 2019, 6: e000862. PMID: 30774963, PMCID: PMC6350752, DOI: 10.1136/openhrt-2018-000862.Peer-Reviewed Original ResearchBovine aortic archSimple renal cystsThoracic aortic diseaseAbdominal aortic aneurysmType B aortic dissectionB aortic dissectionAortic dissectionAortic aneurysmAortic diseaseAortic archRenal cystsChronic kidney diseasePresence of hypertensionAortic aneurysm developmentAbdominal CTMultivariable analysisKidney diseaseRetrospective searchPatientsAneurysm developmentAneurysmsPropensity scoreDiseaseDissectionPrevalence
2018
Descending threshold for ascending aortic aneurysmectomy: Is it time for a “left-shift” in guidelines?
Ziganshin BA, Zafar MA, Elefteriades JA. Descending threshold for ascending aortic aneurysmectomy: Is it time for a “left-shift” in guidelines? Journal Of Thoracic And Cardiovascular Surgery 2018, 157: 37-42. PMID: 30557953, DOI: 10.1016/j.jtcvs.2018.07.114.Peer-Reviewed Original ResearchConceptsAortic sizeSmaller aortic sizeThoracic aortic diseaseAortic aneurysmectomyAortic surgeryAortic dissectionAortic catastropheAortic diameterAortic diseaseAortic aneurysmCurrent guidelinesLeftward shiftNatural historyGenetic testingMore granular dataCenterline methodGenetic defectsAneurysmsFamily membersGuidelinesAneurysmectomyPatientsSurgeryAortaChapter 3 Histology of Aortic Disease and Progression of Aortic Dissection From Acute to Chronic
Zafar M, Peterss S, Ziganshin B, Elefteriades J. Chapter 3 Histology of Aortic Disease and Progression of Aortic Dissection From Acute to Chronic. 2018, 41-59. DOI: 10.1016/b978-0-12-809979-7.00003-1.Peer-Reviewed Original ResearchChronic stateUncomplicated acute type B dissectionAcute type B dissectionAcute Stanford typeType B dissectionEarly surgical interventionTreatment of choiceChronic dissectionB dissectionStanford typeAortic dissectionMedical therapyAortic diseaseSurgical interventionDissectionAortaTemporal courseHistologyMorphological changesAcuteChronicHistopathologyTherapyDiseaseProgression
2017
Medical management of aortic disease in Marfan syndrome.
Bin Mahmood SU, Velasquez CA, Zafar MA, Saeyeldin AA, Brownstein AJ, Ziganshin BA, Elefteriades JA, Mukherjee SK. Medical management of aortic disease in Marfan syndrome. Annals Of Cardiothoracic Surgery 2017, 6: 654-661. PMID: 29270377, PMCID: PMC5721117, DOI: 10.21037/acs.2017.11.09.Peer-Reviewed Original ResearchAngiotensin receptor blockersMedical managementMarfan syndromeMFS patientsThoracic aortic aneurysm diseaseDifferent medical regimensStandard of careAortic aneurysm diseaseNumerous pathophysiological effectsAortic dilatationReceptor blockersAortic diseaseMedical regimensCurrent guidelinesAneurysm diseaseCardiovascular organsΒ-blockersCurrent evidencePathophysiological effectsHereditary disorderPatientsSyndromeDiseaseRegimensManagementDoes BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery?
Ma WG, Ziganshin BA, Guo CF, Zafar MA, Sieller RS, Tranquilli M, Elefteriades JA. Does BioGlue contribute to anastomotic pseudoaneurysm after thoracic aortic surgery? Journal Of Thoracic Disease 2017, 9: 2491-2497. PMID: 28932555, PMCID: PMC5594166, DOI: 10.21037/jtd.2017.06.120.Peer-Reviewed Original ResearchAnastomotic pseudoaneurysm formationThoracic aortic diseaseThoracic aortic surgeryUse of BioGluePseudoaneurysm formationSurgical repairAortic diseaseAortic surgeryAnastomotic pseudoaneurysmFollow-up computed tomography scanEmergency/urgent surgeryAortic surgical proceduresThoracic aortic aneurysmComputed tomography scanArch replacementOperative survivorsAortic ulcerIntramural hematomaOperative mortalityUrgent surgeryNeurologic deficitsAortic dissectionSurgical indicationsHemostatic adjunctMean age