2024
Overestimation of Severe Acute Respiratory Syndrome Coronavirus 2 Household Transmission in Settings of High Community Transmission: Insights From an Informal Settlement Community in Salvador, Brazil
Ticona J, Nery N, Hitchings M, Belitardo E, Fofana M, Dorión M, Victoriano R, Cruz J, Santana J, de Moraes L, Cardoso C, Ribeiro G, Reis M, Khouri R, Costa F, Ko A, Cummings D. Overestimation of Severe Acute Respiratory Syndrome Coronavirus 2 Household Transmission in Settings of High Community Transmission: Insights From an Informal Settlement Community in Salvador, Brazil. Open Forum Infectious Diseases 2024, 11: ofae065. PMID: 38516384, PMCID: PMC10957159, DOI: 10.1093/ofid/ofae065.Peer-Reviewed Original ResearchSARS-CoV-2Household transmissionRT-PCR positive casesSecondary attack rateAttack rateSARS-CoV-2 infectionSARS-CoV-2 Omicron variantRisk of infectionCommunity acquisitionTherapeutic optionsCOVID-19-related symptomsCase-finding studyHousehold contactsAcquisition of SARS-CoV-2Increased riskSymptom onsetSecondary infectionBooster vaccinationSevere outcomesBiweekly visitsHighest attack rateRT-PCRInfectionCOVID-19 severe outcomesOmicron BA
2023
Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas
de Moraes L, Portilho M, Vrancken B, Van den Broeck F, Santos L, Cucco M, Tauro L, Kikuti M, Silva M, Campos G, Reis M, Barral A, Barral-Netto M, Boaventura V, Vandamme A, Theys K, Lemey P, Ribeiro G, Khouri R. Analyses of Early ZIKV Genomes Are Consistent with Viral Spread from Northeast Brazil to the Americas. Viruses 2023, 15: 1236. PMID: 37376536, PMCID: PMC10301521, DOI: 10.3390/v15061236.Peer-Reviewed Original ResearchConceptsAcute ZIKV infectionSpread of ZIKVPublic health responseZika virus outbreakClinical symptomsZIKV infectionHealth responseZIKVZIKV genomeViral spreadGenomic surveillanceVirus outbreakInfectionSubsequent disseminationSurveillance effortsZIKV dynamicsFuture surveillance effortsOutbreakEarly stagesEpidemiological indicators of Chagas disease in the metropolitan region of Salvador, Bahia, Brazil
Lanza F, Ribeiro-Jr G, Miranda D, Santos F, Carvalho C, Cunha G, Carneiro I, Reis R, Cunha J, Cardoso C, Soares J, Araújo F, Reis M. Epidemiological indicators of Chagas disease in the metropolitan region of Salvador, Bahia, Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0185-2022. PMID: 36820652, PMCID: PMC9957123, DOI: 10.1590/0037-8682-0185-2022.Peer-Reviewed Original ResearchAccuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study
Pieri O, Bezerra F, Coelho P, Enk M, Favre T, Graeff-Teixeira C, Oliveira R, Reis M, Andrade L, Beck L, Favero V, Fialho T, Guimarães R, Oliveira B, Pascoal V, Pinheiro M, Santos R, Silva L, Siqueira I, Souza R, Katz N. Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study. Revista Da Sociedade Brasileira De Medicina Tropical 2023, 56: e0238-2022. PMID: 36700600, PMCID: PMC9870275, DOI: 10.1590/0037-8682-0238-2022.Peer-Reviewed Original ResearchConceptsCathodic antigenKato-KatzUrine-based pointSchistosomiasis mansoni infectionDifferent prevalence estimatesCare diagnostic testsSchistosomiasis elimination programmesWorld Health OrganizationMansoni infectionMulticenter studyStool samplesUrine pointPrevalence estimatesS. mansoniElimination programInfection statusDiagnostic testsHealth OrganizationUrine samplesHelmintexAntigenInfectionPrevalenceMansoniCare
2022
Rickettsial Infections Causing Acute Febrile Illness in Urban Slums, Brazil - Volume 28, Number 10—October 2022 - Emerging Infectious Diseases journal - CDC
Fournier JB, Blanton LS, Nery N, Wunder EA, Costa F, Reis MG, Ribeiro GS, Walker DH, Ko AI. Rickettsial Infections Causing Acute Febrile Illness in Urban Slums, Brazil - Volume 28, Number 10—October 2022 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2022, 28: 2132-2134. PMID: 36148970, PMCID: PMC9514363, DOI: 10.3201/eid2810.220497.Peer-Reviewed Original ResearchBiannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil
Cruz J, Nery N, Sacramento G, Victoriano R, Montenegro A, Santana J, Costa F, Ko A, Reis M, Wunder E. Biannual and Quarterly Comparison Analysis of Agglutinating Antibody Kinetics on a Subcohort of Individuals Exposed to Leptospira interrogans in Salvador, Brazil. Frontiers In Medicine 2022, 9: 862378. PMID: 35492362, PMCID: PMC9048256, DOI: 10.3389/fmed.2022.862378.Peer-Reviewed Original ResearchMicroscopic agglutination testAntibody kineticsEndemic areasReinfection eventsSubcohort of individualsBurden of leptospirosisLife-threatening diseaseProspective cohortClinical manifestationsAsymptomatic infectionHumoral responseRisk factorsImmune responseLeptospirosis infectionAgglutination testPaucity of informationSerological surveyLeptospirosisSample collection timeInfectionLeptospira interrogansSubcohortFurther studiesHigh rateDisease
2020
Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection
Portilho M, de Moraes L, Kikuti M, Nascimento L, Reis M, Boaventura V, Khouri R, Ribeiro G. Accuracy of the Zika IgM Antibody Capture Enzyme-Linked Immunosorbent Assay from the Centers for Disease Control and Prevention (CDC Zika MAC-ELISA) for Diagnosis of Zika Virus Infection. Diagnostics 2020, 10: 835. PMID: 33080935, PMCID: PMC7603149, DOI: 10.3390/diagnostics10100835.Peer-Reviewed Original ResearchDays post-symptom onsetZika virus infectionConvalescent-phase seraVirus infectionRT-PCRDengue virusSerological diagnosisDengue casesPost-symptom onsetConvalescent-phase samplesBlood donor samplesIgM antibody capture enzymeEnzyme-linked immunosorbent assayZika IgM antibodySymptom onsetDENV infectionIgM antibodiesZIKV infectionBlood donorsDonor samplesCapture enzymeOutbreak investigationDisease controlInfectionImmunosorbent assayInfluence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC
Hacker KP, Sacramento GA, Cruz JS, de Oliveira D, Nery N, Lindow JC, Carvalho M, Hagan J, Diggle PJ, Begon M, Reis MG, Wunder EA, Ko AI, Costa F. Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 311-314. PMID: 31961288, PMCID: PMC6986844, DOI: 10.3201/eid2602.190102.Peer-Reviewed Original Research
2019
Coinfection modifies carriage of enzootic and zoonotic parasites in Norway rats from an urban slum
Carvalho‐Pereira T, Souza F, do Nascimento Santos L, Pedra G, Minter A, Bahiense T, Reis M, Ko A, Childs J, da Silva E, Costa F, Begon M. Coinfection modifies carriage of enzootic and zoonotic parasites in Norway rats from an urban slum. Ecosphere 2019, 10 DOI: 10.1002/ecs2.2887.Peer-Reviewed Original ResearchUrban slumsLoad of parasitesZoonotic parasitesUrban ratsStrongyloides spBrazilian urban slumsIntensity of infectionReduced prevalenceNippostrongylus brasiliensisCoinfectionSignificant associationInfection riskRatsNematode Angiostrongylus cantonensisAngiostrongylus cantonensisInfectionNorway ratsEggs/larvaeCantonensisZoonotic pathogensCorrelation testInterrogansParasitesPopulationBloodstream infections caused by multidrug-resistant gram-negative bacteria: epidemiological, clinical and microbiological features
Leal H, Azevedo J, Silva G, Amorim A, de Roma L, Arraes A, Gouveia E, Reis M, Mendes A, de Oliveira Silva M, Barberino M, Martins I, Reis J. Bloodstream infections caused by multidrug-resistant gram-negative bacteria: epidemiological, clinical and microbiological features. BMC Infectious Diseases 2019, 19: 609. PMID: 31296179, PMCID: PMC6624930, DOI: 10.1186/s12879-019-4265-z.Peer-Reviewed Original ResearchConceptsK. pneumoniaePrevious antimicrobial useLaboratory-based surveillanceAntimicrobial susceptibility testingMDR bacteremiaMDR-GNBDrug-resistant pathogensNegative bacteremiaLiver diseaseBloodstream infectionsHigh morbidityMale sexRisk factorsEpidemiological aspectsNegative bacilliHealthcare professionalsMicrobiological featuresSusceptibility testingBacteremiaInfectionAntimicrobial useCausative agentAntibiotic resistanceIntervention measuresResistance determinantsPrevalence of Infection of Biomphalaria glabrata by Schistosoma mansoni and the risk of urban Schistosomiasis mansoni in Salvador, Bahia, Brazil
Zanardi V, Barbosa L, Simões F, Thiengo S, Blanton R, Ribeiro Junior G, Silva L, Reis M. Prevalence of Infection of Biomphalaria glabrata by Schistosoma mansoni and the risk of urban Schistosomiasis mansoni in Salvador, Bahia, Brazil. Revista Da Sociedade Brasileira De Medicina Tropical 2019, 52: e20190171. PMID: 31508782, DOI: 10.1590/0037-8682-0171-2019.Peer-Reviewed Original ResearchConceptsMansoni infectionS. mansoniSubunit-specific primersSchistosoma mansoni infectionS. mansoni infectionB. glabrataS. mansoni prevalenceCercarial sheddingReal-time polymerase chain reactionPublic health planningTime polymerase chain reactionPrevalence of infectionS. mansoni DNABiomphalaria glabrataSchistosomiasis mansoniPolymerase chain reactionHigh prevalenceHealth planningSchistosoma mansoniInfectionPrevalenceIncidence of schistosomiasisMansoniSchistosomiasis transmissionChain reaction
2018
437. Spatial Distribution of Schistosomiasis After Repeated Praziquantel Treatments in a Rural Community in Brazil
Terashima R, Blanton R, Reis M. 437. Spatial Distribution of Schistosomiasis After Repeated Praziquantel Treatments in a Rural Community in Brazil. Open Forum Infectious Diseases 2018, 5: s165-s165. PMCID: PMC6255532, DOI: 10.1093/ofid/ofy210.447.Peer-Reviewed Original ResearchCommunity-wide treatmentSchistosomiasis prevalenceWater contact sitesPrevalence of schistosomiasisIndicator markersPrevalence of infectionTransmission persistsPraziquantel treatmentDistribution of infectionKato-KatzPrevalenceSchistosomiasisTreatment effortsStudy periodTreatmentPraziquantelRural communitiesInfectionMinimal fluctuationsMarkersMorbidityReinfectionStoolYearsDisease
2016
Factors affecting carriage and intensity of infection of Calodium hepaticum within Norway rats (Rattus norvegicus) from an urban slum environment in Salvador, Brazil
WALKER R, CARVALHO-PEREIRA T, SERRANO S, PEDRA G, HACKER K, TAYLOR J, MINTER A, PERTILE A, PANTI-MAY A, CARVALHO M, SOUZA FN, NERY N, RODRIGUES G, BAHIENSE T, REIS MG, KO AI, CHILDS JE, BEGON M, COSTA F. Factors affecting carriage and intensity of infection of Calodium hepaticum within Norway rats (Rattus norvegicus) from an urban slum environment in Salvador, Brazil. Epidemiology And Infection 2016, 145: 334-338. PMID: 27780498, PMCID: PMC6247895, DOI: 10.1017/s0950268816002259.Peer-Reviewed Original ResearchConceptsIntensity of infectionNorway ratsIndependent risk factorC. hepaticumHumans of exposureUrban slum environmentsCalodium hepaticumUrban slum areaSlum areasLiver involvementMammalian hostsRisk factorsInfective eggsRatsCarriage levelsSignificant riskInfectionUrban slumsCarriageFurther studiesSub-standard living conditionsRiskZoonotic pathogensSlum environmentRodent-borne zoonotic pathogens
2014
HBV/HDV co‐infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
Kay A, da Silva E, Pedreira H, Negreiros S, Lobato C, Braga W, Muwonge R, Dény P, Reis M, Zoulim F, Trepo C, D'Oliveira A, Salcedo J, Schinoni M, Parana R. HBV/HDV co‐infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers. Journal Of Viral Hepatitis 2014, 21: 921-924. PMID: 25040045, DOI: 10.1111/jvh.12267.Peer-Reviewed Original Research
2013
Longitudinal surveillance for meningitis by Acinetobacter in a large urban setting in Brazil
Coelho-Souza T, Reis J, Martins N, Martins I, Menezes A, Reis M, Silva N, Dias R, Riley L, Moreira B. Longitudinal surveillance for meningitis by Acinetobacter in a large urban setting in Brazil. Clinical Microbiology And Infection 2013, 19: e241-e244. PMID: 23398654, PMCID: PMC3625502, DOI: 10.1111/1469-0691.12145.Peer-Reviewed Original ResearchMeSH KeywordsAcinetobacter baumanniiAcinetobacter InfectionsAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsBrazilCarbapenemsChildChild, PreschoolColistinDrug Resistance, Multiple, BacterialEpidemiological MonitoringFemaleHumansMaleMeningitis, BacterialMiddle AgedMolecular EpidemiologyMultilocus Sequence TypingUrban PopulationYoung AdultConceptsMultilocus sequence typingA. baumanniiCarbapenem resistanceClonal complexesDissemination of infectionLongitudinal surveillanceAcinetobacter baumanniiLarge urban settingMeningitisStudy aimBaumanniiSequence typingUrban settingsAntimicrobial agentsSurveillance systemSurveillanceColistinInfectionSetting
2009
Analysis of discordance between the tuberculin skin test and the interferon-gamma release assay.
Machado A, Emodi K, Takenami I, Finkmoore B, Barbosa T, Carvalho J, Cavalcanti L, Santos G, Tavares M, Mota M, Barreto F, Reis M, Arruda S, Riley L. Analysis of discordance between the tuberculin skin test and the interferon-gamma release assay. The International Journal Of Tuberculosis And Lung Disease 2009, 13: 446-53. PMID: 19335949.Peer-Reviewed Original ResearchConceptsTuberculin skin testInterferon-gamma releaseHousehold contactsSkin testTST resultsLatent TB infectionPositive TST resultsPulmonary tuberculosis patientsChest X-rayAnalysis of discordancePTB patientsTB infectionTuberculosis patientsLung scarsIndex caseTest groupTest agreementPatientsIGRAPositive resultsGroupDiscordanceInfectionRelease
2007
Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection
de Faria M, Athanazio DA, Ramos E, Silva EF, Reis MG, Ko AI. Morphological Alterations in the Kidney of Rats with Natural and Experimental Leptospira Infection. Journal Of Comparative Pathology 2007, 137: 231-238. PMID: 17996544, DOI: 10.1016/j.jcpa.2007.08.001.Peer-Reviewed Original ResearchConceptsInterstitial nephritisPathology of leptospirosisKidneys of ratsMorphological alterationsPathogenesis of leptospirosisFiocruz L1-130Leptospiral diseaseWistar ratsLeptospira infectionPathological changesUrban outbreaksRecreational exposureHuman infectionsL1-130RatsWidespread anthropozoonosisKidneyLeptospira interrogansLeptospirosisNephritisInfectionDiseaseEmergent diseaseMammalian reservoirsHost resistance
2001
Leptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans
Guerreiro H, Croda J, Flannery B, Mazel M, Matsunaga J, Reis M, Levett P, Ko A, Haake D. Leptospiral Proteins Recognized during the Humoral Immune Response to Leptospirosis in Humans. Infection And Immunity 2001, 69: 4958-4968. PMID: 11447174, PMCID: PMC98588, DOI: 10.1128/iai.69.8.4958-4968.2001.Peer-Reviewed Original ResearchConceptsHumoral immune responseImmune responseNatural infectionLeptospiral proteinsInfection-associated antigenConvalescent-phase seraPositive reactionConvalescent phaseHumoral responseHealthy individualsHuman leptospirosisControl individualsVaccine designImmunodominant antigensQuantitative immunoblot analysisTwo-dimensional immunoblotsProtein antigensPathogenic leptospiral strainsGenus LeptospiraInfectionAntigenLeptospirosisSerumImmunodominant proteinsPatients
2000
Lower Hookworm Incidence, Prevalence, and Intensity of Infection in Children with a Bacillus Calmette-Guérin Vaccination Scar
Barreto M, Rodrigues L, Silva R, Assis A, Reis M, Santos C, Blanton R. Lower Hookworm Incidence, Prevalence, and Intensity of Infection in Children with a Bacillus Calmette-Guérin Vaccination Scar. The Journal Of Infectious Diseases 2000, 182: 1800-1803. PMID: 11069259, DOI: 10.1086/317627.Peer-Reviewed Original ResearchConceptsBCG vaccination scarBacillus Calmette-GuérinVaccination scarIntensity of infectionBacillus Calmette-Guérin (BCG) vaccination scarHuman immunodeficiency virus-infected adultsHuman immunological responsesOngoing prospective studyVaccination protectionIncidence ratiosProspective studyAdjusted prevalenceHookworm infectionCalmette-GuérinTrichuris trichiuraImmunological responseCommon vaccinesImmune systemHookworm prevalenceDifferent helminthsLogistic regressionPrevalenceSchistosoma mansoniIncidenceInfectionClonally Related Penicillin-Nonsusceptible Streptococcus pneumoniae Serotype 14 from Cases of Meningitis in Salvador, Brazil
Ko A, Reis J, Coppola S, Gouveia E, Cordeiro S, Lôbo T, Pinheiro R, Salgado K, Dourado C, Tavares-Neto J, Rocha H, Reis M, Johnson W, Riley L. Clonally Related Penicillin-Nonsusceptible Streptococcus pneumoniae Serotype 14 from Cases of Meningitis in Salvador, Brazil. Clinical Infectious Diseases 2000, 30: 78-86. PMID: 10619737, DOI: 10.1086/313619.Peer-Reviewed Original ResearchConceptsPenicillin-nonsusceptible isolatesSerotype 14 isolatesSerotype 14Pneumococcal meningitisActive hospital-based surveillanceCases of meningitisHospital-based surveillancePrevious antibiotic useIntermediate-level resistanceSerotype 14 strainsPolymerase chain reaction analysisAntibiotic useChain reaction analysisPrevalent serotypesMeningitisUnrelated patternsPCR patternsCity of SalvadorPatientsStreptococcus pneumoniae serotype 14Reaction analysisIsolatesLarge proportionGeographic areasInfection