Featured Publications
Histopathologic and Machine Deep Learning Criteria to Predict Lymphoma Transformation in Bone Marrow Biopsies.
Irshaid L, Bleiberg J, Weinberger E, Garritano J, Shallis RM, Patsenker J, Lindenbaum O, Kluger Y, Katz SG, Xu ML. Histopathologic and Machine Deep Learning Criteria to Predict Lymphoma Transformation in Bone Marrow Biopsies. Archives Of Pathology & Laboratory Medicine 2021, 146: 182-193. PMID: 34086849, DOI: 10.5858/arpa.2020-0510-oa.Peer-Reviewed Original ResearchConceptsLarge cell transformationChronic lymphocytic leukemiaBone marrow biopsyMarrow biopsyFollicular lymphomaIndolent B-cell lymphomaLarge lymphoma cellsClinical disease progressionDiagnosis of FLFinal outcome dataB-cell lymphomaLarge tumor cellsEase of procedureAggressive chemotherapyLow morbidityLymph nodesWorse prognosisWhole slide scansHistologic findingsPatient's probabilityDisease progressionLymphocytic leukemiaLymphoma transformationClinical questionsOutcome data
2022
Peripheral Blood Involvement at Staging in Patients With Aggressive Peripheral T-Cell Lymphoma
Avery J, Chandhok N, Rainey C, Torres R, Huntington S, Isufi I, Seropian S, Xu ML, Foss F. Peripheral Blood Involvement at Staging in Patients With Aggressive Peripheral T-Cell Lymphoma. Clinical Lymphoma Myeloma & Leukemia 2022, 22: 680-689. PMID: 35568635, DOI: 10.1016/j.clml.2022.04.019.Peer-Reviewed Original ResearchConceptsPeripheral T-cell lymphomaT-cell lymphomaBone marrow involvementBlood involvementFlow cytometryMarrow involvementNodal subtypesAggressive peripheral T-cell lymphomaNodal T-cell lymphomasNegative flow cytometryPeripheral blood involvementPositive flow cytometryMalignant T cellsMalignant tumor cellsMedian PFSTime ofdiagnosisOverall survivalLymph nodesPoor outcomeDisease stagePeripheral bloodT cellsPrognostic measuresRare subgroupLymphoma
2021
Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis
Gisriel S, Hung K, Braddock D, Seropian S, Foss F, Robert M, Xu M. Simultaneous colonic T-cell lymphoma and graft-versus-host disease: A rare diagnosis. Human Pathology Reports 2021, 24: 200507. DOI: 10.1016/j.ehpc.2021.200507.Peer-Reviewed Case Reports and Technical NotesCutaneous T-cell lymphomaT-cell lymphomaPost-transplant lymphoproliferative disorderAllogeneic stem cell transplantAtypical lymphoid infiltrateStem cell transplantCritical clinical implicationsLimited tissue samplesAbdominal painHost diseaseGastrointestinal biopsiesLymph nodesCell transplantLymphoid infiltratesLymphoproliferative disordersMycosis fungoidesRare diagnosisDiagnostic workupDifferential diagnosisIntestinal mucosaClinical implicationsTissue samplesLymphomaGraftDiagnosis
2020
Diffuse large B-cell and follicular lymphoma presenting as a slowly growing compressive goiter: A case report and literature review
Lin N, Vargas-Pinto S, Gisriel S, Xu M, Gibson CE. Diffuse large B-cell and follicular lymphoma presenting as a slowly growing compressive goiter: A case report and literature review. International Journal Of Surgery Case Reports 2020, 72: 615-619. PMID: 32698301, PMCID: PMC7334388, DOI: 10.1016/j.ijscr.2020.06.029.Peer-Reviewed Original ResearchFine needle aspiration cytologyThyroid lymphomaLymphoproliferative processDiffuse large B-cellStage IIE diseaseInvolved-field radiotherapyChronic lymphocytic thyroiditisCore needle biopsyB cell componentLarge B-cellChest lymph nodesChronic lymphocytic infiltrationIIE diseaseIndolent typeStaging workupCompressive symptomsCombination chemotherapyLymph nodesNeck ultrasonographyThyroid lobectomyLymphocytic infiltrationHistological diagnosisHistological subtypesLymphocytic thyroiditisNeck massBenign lymph node microenvironment is associated with response to immunotherapy
Toki MI, Kumar D, Ahmed FS, Rimm DL, Xu ML. Benign lymph node microenvironment is associated with response to immunotherapy. Precision Clinical Medicine 2020, 3: 44-53. PMID: 35693430, PMCID: PMC8985791, DOI: 10.1093/pcmedi/pbaa003.Peer-Reviewed Original ResearchBenign lymph nodesLymph nodesT cellsQuantitative immunofluorescenceBenign lymphPD-L1Immune checkpoint blockade therapyMultiplexed quantitative immunofluorescenceHigh expressionCheckpoint blockade therapyMacrophage marker expressionSignificant differencesCytotoxic markersBlockade therapyBenign findingsCancer patientsLymphoid tissueImmune surveillanceTreatment responsePostmortem examinationImmunotherapyProliferation indexSplenic tissueB cellsPatients
2018
Small Cell Variant of Intravascular Large B‐Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis
Rahmani M, Halene S, Xu ML. Small Cell Variant of Intravascular Large B‐Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis. BioMed Research International 2018, 2018: 9413015. PMID: 29850589, PMCID: PMC5903319, DOI: 10.1155/2018/9413015.Peer-Reviewed Case Reports and Technical NotesConceptsIntravascular large B-cell lymphomaB-cell lymphomaLarge B-cell lymphomaSmall cell morphologySmall cell variantCases of IVLBCLCell variantHodgkin's B-cell lymphomaRandom skin biopsySmall bowel biopsyHigh clinical suspicionLarge atypical cellsSmall cell lymphomaSmall blood vesselsBowel biopsyClinical suspicionLymph nodesRetrospective reviewClinicopathologic featuresSmall bowelPoor prognosisAtypical cellsFallopian tubeSkin biopsiesDifferential diagnosis
2017
Lymph node stromal and vascular proliferations
Xu ML, O’Malley D. Lymph node stromal and vascular proliferations. Seminars In Diagnostic Pathology 2017, 35: 67-75. PMID: 29173940, DOI: 10.1053/j.semdp.2017.11.004.Peer-Reviewed Original Research
2012
Composite Peripheral T-cell Lymphoma Not Otherwise Specified, and B-cell Small Lymphocytic Lymphoma Presenting With Hemophagocytic Lymphohistiocytosis
Alomari A, Hui P, Xu M. Composite Peripheral T-cell Lymphoma Not Otherwise Specified, and B-cell Small Lymphocytic Lymphoma Presenting With Hemophagocytic Lymphohistiocytosis. International Journal Of Surgical Pathology 2012, 21: 303-308. PMID: 23129836, DOI: 10.1177/1066896912464047.Peer-Reviewed Original ResearchConceptsPeripheral T-cell lymphomaT-cell lymphomaHemophagocytic lymphohistiocytosisB-cell lymphomaB-cell small lymphocytic lymphoma/chronic lymphocytic leukemiaSmall lymphocytic lymphoma/chronic lymphocytic leukemiaDevelopment of HLHPatient's B-cell lymphomaSymptoms of HLHComposite B-cellPara-aortic lymphadenopathyBone marrow examinationGood initial responseHigh-grade lymphomaChronic lymphocytic leukemiaLymphoma PresentingMarrow examinationPara-aorticImmune dysregulationLymph nodesFemale patientsDifferent regimensHepatocellular necrosisComposite lymphomaLymphocytic leukemia