Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice
Nagy D, Martens LH, Leventhal L, Chen A, Kelley C, Stoiljkovic M, Hajós M. Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice. Alzheimer's Research & Therapy 2019, 11: 88. PMID: 31639062, PMCID: PMC6805349, DOI: 10.1186/s13195-019-0540-x.Peer-Reviewed Original ResearchConceptsHomozygous miceProgranulin deficiencyBehavioral abnormalitiesFrontotemporal dementiaAge-dependent emergenceHuman frontotemporal dementiasProgranulin-deficient miceExtensive neuronal lossAge-dependent deficitsPaired-pulse depressionHeterogeneous neurodegenerative disorderNeuronal lossVivo electrophysiologyCortical pathwaysThalamocortical circuitsTemporal lobeSynaptic connectivityBehavioral alterationsConclusionOur findingsNeurodegenerative disordersMiceFunction mutationsAge 3DementiaAbnormalities