2023
Maternal diabetes in youth-onset type 2 diabetes is associated with progressive dysglycemia and risk of complications
RD S, SD C, L E, ME G, J K, MM K, R F, B T, JB T, M V, E I. Maternal diabetes in youth-onset type 2 diabetes is associated with progressive dysglycemia and risk of complications. 2023 DOI: 10.1530/ey.20.10.7.Peer-Reviewed Original Research
2021
Colonic Fermentation and Acetate Production in Youth with and without Obesity
Galuppo B, Cline G, Van Name M, Shabanova V, Wagner D, Kien CL, Santoro N. Colonic Fermentation and Acetate Production in Youth with and without Obesity. Journal Of Nutrition 2021, 151: 3292-3298. PMID: 34494088, PMCID: PMC8562084, DOI: 10.1093/jn/nxab277.Peer-Reviewed Original ResearchConceptsDe novo lipogenesisLean youthLactulose ingestionGut microbiotaHepatic de novo lipogenesisDevelopment of obesityColonic acetateOral doseIntravenous infusionPeripheral circulationColonic fermentationNovo lipogenesisObesityRate of appearanceAge 15Spearman correlationIngestionLactuloseRegression modelsMicrobiotaLesser degreeComplicationsGroupInfusionFerment carbohydratesLong-Term Complications in Youth-Onset Type 2 Diabetes
Bjornstad P, Drews K, Caprio S, Gubitosi-Klug R, Nathan D, Tesfaldet B, Tryggestad J, White N, Zeitler P. Long-Term Complications in Youth-Onset Type 2 Diabetes. New England Journal Of Medicine 2021, 385: 416-426. PMID: 34320286, PMCID: PMC8697255, DOI: 10.1056/nejmoa2100165.Peer-Reviewed Original ResearchConceptsType 2 diabetesDiabetic kidney diseaseNerve diseaseKidney diseaseRetinal diseasesYouth-Onset Type 2Minority raceDevelopment of complicationsIncidence of dyslipidemiaRisk of complicationsMulticenter clinical trialDiagnosis of diabetesMicrovascular complicationsAdverse eventsCumulative incidenceTerm complicationsGlycemic controlRelated complicationsObservational followMean ageRisk factorsClinical trialsComplicationsDyslipidemiaHypertension