Featured Publications
fMRI Neurofeedback
Hampson, M., editor. fMRI Neurofeedback. Published in 2021 by Academic Press, Elsevier, Inc., London, United Kingdom.BooksFunctional connectivity between task-positive and task-negative brain areas and its relation to working memory performance
Hampson M, Driesen N, Roth JK, Gore JC, Constable RT. Functional connectivity between task-positive and task-negative brain areas and its relation to working memory performance. Magnetic Resonance Imaging 2010, 28: 1051-1057. PMID: 20409665, PMCID: PMC2936669, DOI: 10.1016/j.mri.2010.03.021.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexCognitive tasksBrain areasCognitive functionPrefrontal cortexTask-negative regionsWhole-brain correlationMedial frontal cortexAnterior cingulate cortexGroup-level analysisMemory performanceFunctional brainCingulate cortexFunctional connectivityFrontal cortexFunctional connectionsCortexTaskRelationshipNegative correlationValidityConnectivityBrainFindingsRegressionBrain Connectivity Related to Working Memory Performance
Hampson M, Driesen NR, Skudlarski P, Gore JC, Constable RT. Brain Connectivity Related to Working Memory Performance. Journal Of Neuroscience 2006, 26: 13338-13343. PMID: 17182784, PMCID: PMC2677699, DOI: 10.1523/jneurosci.3408-06.2006.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory taskCognitive tasksCingulate cortexVentral anterior cingulate cortexDifferent cognitive tasksMedial frontal regionsMedial frontal gyrusDefault mode networkAnterior cingulate cortexFunctional imaging studiesCognitive abilitiesIndividual differencesMemory performanceCognitive performanceFrontal gyrusMode networkFrontal regionsFunctional connectivityBrain connectivityBrain areasTaskFunctional connectionsImaging studiesCortexDetection of functional connectivity using temporal correlations in MR images
Hampson M, Peterson BS, Skudlarski P, Gatenby JC, Gore JC. Detection of functional connectivity using temporal correlations in MR images. Human Brain Mapping 2002, 15: 247-262. PMID: 11835612, PMCID: PMC6872035, DOI: 10.1002/hbm.10022.Peer-Reviewed Original ResearchAmygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial
Zhao Z, Duek O, Seidemann R, Gordon C, Walsh C, Romaker E, Koller W, Horvath M, Awasthi J, Wang Y, O’Brien E, Fichtenholtz H, Hampson M, Harpaz-Rotem I. Amygdala downregulation training using fMRI neurofeedback in post-traumatic stress disorder: a randomized, double-blind trial. Translational Psychiatry 2023, 13: 177. PMID: 37230984, PMCID: PMC10209552, DOI: 10.1038/s41398-023-02467-6.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderControl groupAmygdala activityPTSD treatmentDouble-blind clinical trialStress disorderDouble-blind trialSecondary outcome measurementsTrauma recallNeurofeedback trainingGreater improvementAmygdala controlsPotential clinical applicationsSymptom scoresActive groupClinical trialsTreatment successOutcome measurementsTrauma scriptsSymptom reductionNeurofeedback interventionPTSD symptomsFMRI neurofeedbackAmygdalaNeural markersRandomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome
Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Biological Psychiatry 2019, 87: 1063-1070. PMID: 31668476, PMCID: PMC7015800, DOI: 10.1016/j.biopsych.2019.07.035.Peer-Reviewed Original ResearchConceptsSupplementary motor areaYale Global Tic Severity ScaleFunctional magnetic resonanceTic Severity ScaleReal-time functional magnetic resonanceTourette syndromeSeverity ScaleYale Global Tic Severity Scale-Total Tic ScoreTotal tic scorePrimary outcome measureSham control conditionReduction of ticsMagnetic resonanceSecondary outcomesSessions of neurofeedbackCrossover studyTic symptomsTic scoreOutcome measuresMotor areaSecondary measuresTic severityReal neurofeedbackEnd pointNeurofeedback interventionTime course of clinical change following neurofeedback
Rance M, Walsh C, Sukhodolsky DG, Pittman B, Qiu M, Kichuk SA, Wasylink S, Koller WN, Bloch M, Gruner P, Scheinost D, Pittenger C, Hampson M. Time course of clinical change following neurofeedback. NeuroImage 2018, 181: 807-813. PMID: 29729393, PMCID: PMC6454268, DOI: 10.1016/j.neuroimage.2018.05.001.Peer-Reviewed Original ResearchConceptsClinical changesSymptom changeTime courseBrain functionNeurofeedback studiesPotential clinical toolCrossover designControl interventionsReal neurofeedbackClinical toolTime pointsClinical populationsNeurofeedback effectsInterventionNeurofeedback sessionsNeurofeedbackCurrent brain stateWeeksBrain statesNew studiesCourseSessionsSymptomsOrbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity
Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity. Translational Psychiatry 2013, 3: e250-e250. PMID: 23632454, PMCID: PMC3641411, DOI: 10.1038/tp.2013.24.Peer-Reviewed Original ResearchConceptsResting-state connectivityContamination anxietyBrain regionsNF trainingBrain connectivityResting-state functional connectivityFunctional magnetic resonance imaging (fMRI) neurofeedbackPotential of neurofeedbackRelevant brain networksResting-state fMRIDorsolateral prefrontal cortexTarget brain regionsBrain functional architectureUseful therapyLimbic circuitryMatched subjectsOrbitofrontal regionsOrbitofrontal cortexFunctional connectivityPrefrontal cortexHuman emotionsFeedback control tasksSubclinical anxietyAnxiety regulationBrain networks
2024
Neurofeedback: potential for abuse and regulatory frameworks in the United States
Furnari F, Park H, Yaffe G, Hampson M. Neurofeedback: potential for abuse and regulatory frameworks in the United States. Philosophical Transactions Of The Royal Society B Biological Sciences 2024, 379: 20230099. PMID: 39428883, PMCID: PMC11513161, DOI: 10.1098/rstb.2023.0099.Peer-Reviewed Original Research
2023
Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial
Rance M, Zhao Z, Zaboski B, Kichuk S, Romaker E, Koller W, Walsh C, Harris-Starling C, Wasylink S, Adams T, Gruner P, Pittenger C, Hampson M. Neurofeedback for obsessive compulsive disorder: A randomized, double-blind trial. Psychiatry Research 2023, 328: 115458. PMID: 37722238, PMCID: PMC10695074, DOI: 10.1016/j.psychres.2023.115458.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderAnterior prefrontal cortexControl groupDouble-blind clinical trialDouble-blind trialPrimary outcome measureCompulsive disorderHarm/checkingMechanism of actionYale-Brown ObsessiveSecondary outcomesSessions of neurofeedbackActive groupClinical trialsOutcome measuresPrimary symptomsSymptom ScaleObsessive-compulsive symptomsPrefrontal cortexSymptomsTraining protocolGreater reductionSignificant differencesPatientsSham feedbackProtocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome
Awasthi J, Harris-Starling C, Kalvin C, Pittman B, Park H, Bloch M, Fernandez T, Sukhodolsky D, Hampson M. Protocol description for a randomized controlled trial of fMRI neurofeedback for tics in adolescents with Tourette Syndrome. Psychiatry Research Neuroimaging 2023, 336: 111692. PMID: 37673711, PMCID: PMC10722977, DOI: 10.1016/j.pscychresns.2023.111692.Peer-Reviewed Case Reports and Technical NotesConceptsTourette syndromeFunctional magnetic resonance imagingStudy protocolChronic tic disorderSupplementary motor areaLower functional connectivityMagnetic resonance imagingResearch study protocolLarge trialsClinical trialsTic disordersMotor areaBrain areasControl groupResonance imagingBrain regionsNew trialsFunctional connectivityNeurofeedback interventionFMRI neurofeedbackNF protocolTrialsNF studiesSyndromeInterventionFunctional Connectivity MR Imaging
Horien C, Shen X, Scheinost D, Constable R, Hampson M. Functional Connectivity MR Imaging. 2023, 521-541. DOI: 10.1007/978-3-031-10909-6_24.Chapters
2022
HALO: A software tool for real‐time head alignment in the MR scanner
Zhao Z, Galiana G, Zillo C, Camarro T, Qiu M, Papademetris X, Hampson M. HALO: A software tool for real‐time head alignment in the MR scanner. Magnetic Resonance In Medicine 2022, 89: 1506-1513. PMID: 36426774, PMCID: PMC10753491, DOI: 10.1002/mrm.29535.Peer-Reviewed Original ResearchSystemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers
Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers. Brain Behavior And Immunity 2022, 106: 262-269. PMID: 36058419, PMCID: PMC10097458, DOI: 10.1016/j.bbi.2022.08.016.Peer-Reviewed Original ResearchConceptsEffects of LPSDopamine elevationTobacco smokersHealthy controlsSystemic inflammationDopamine systemImmune-brain interactionReward-related brain regionsAdministration of placeboAdministration of LPSSmoking statusRepeated-measures ANOVAPathophysiology of addictionDrug dosingPlaceboIndependent cohortSmokersDrug reinforcementEffect size determinationImmune systemRandomized orderBrain regionsLPSMethylphenidatePBO conditionObsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth
Grazioplene RG, DeYoung CG, Hampson M, Anticevic A, Pittenger C. Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth. Translational Psychiatry 2022, 12: 328. PMID: 35948535, PMCID: PMC9365814, DOI: 10.1038/s41398-022-02013-w.Peer-Reviewed Original ResearchConceptsWhite matter abnormalitiesObsessive-compulsive disorderObsessive-compulsive symptomsGeneral psychopathologyCorpus callosumWhite matterFractional anisotropyDistinct white matter abnormalitiesAnterior corpus callosumPosterior corpus callosumWhite matter correlatesAge-dependent mannerWhite matter measuresGeneral psychopathology factorWhite matter microstructureHarmonization of [11C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects
Hoye J, Toyonaga T, Zakiniaeiz Y, Stanley G, Hampson M, Morris ED. Harmonization of [11C]raclopride brain PET images from the HR+ and HRRT: method development and validation in human subjects. EJNMMI Physics 2022, 9: 27. PMID: 35416555, PMCID: PMC9008103, DOI: 10.1186/s40658-022-00457-z.Peer-Reviewed Original ResearchHuman subjectsNon-displaceable binding potentialPET imaging studiesTest-retest variabilityHarmonization studyStriatal BPNDPercent differenceImaging studiesResultsExperiment 1Inter-scanner variabilityBrain PET imagesBPND estimatesSubjectsOngoing needPET imagesRT variabilityBinding potentialPD resultsBackgroundThereBPNDRTNeurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial
Tinaz S, Kamel S, Aravala SS, Elfil M, Bayoumi A, Patel A, Scheinost D, Sinha R, Hampson M. Neurofeedback-guided kinesthetic motor imagery training in Parkinson’s disease: Randomized trial. NeuroImage Clinical 2022, 34: 102980. PMID: 35247729, PMCID: PMC8897714, DOI: 10.1016/j.nicl.2022.102980.Peer-Reviewed Original ResearchConceptsKinesthetic motor imageryMotor function scoresMild Parkinson's diseaseParkinson's diseaseFunctional connectivityFunction scoresMI trainingSecondary clinical outcomesClinical outcome measuresRandomized clinical trialsWhole-brain functional connectivityPost-training changeFunctional connectivity strengthMotor imageryMotor imagery trainingDorsomedial frontal cortexDistinct neural circuitsClinical outcomesImaging outcomesSubjective improvementClinical trialsMotor functionMotor examFrontal cortexOutcome measures
2021
Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior
Sukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulateFunctional connectivityAnterior cingulateDorsolateral prefrontal cortical regionsResting-state brain connectivityAggressive behaviorResting-state functional connectivityIntrinsic connectivity distributionAmygdala-prefrontal circuitryAnterior cingulate cortexIntrinsic functional connectivityPrefrontal cortical regionsHealthy controlsAmygdala connectivityGreater severityVentromedial prefrontal cortexCingulate cortexFunctional MRI dataCortical regionsMedial prefrontalMaladaptive aggressionPrefrontal cortexBrain connectivitySeverity of aggressionTreatment-seeking childrenChapter 3 Protocol design in fMRI neurofeedback studies
Hampson M, Linden D. Chapter 3 Protocol design in fMRI neurofeedback studies. 2021, 57-79. DOI: 10.1016/b978-0-12-822421-2.00012-0.ChaptersChapter 14 Ethical considerations for fMRI neurofeedback
Cherkaoui M, Rissman J, Lau H, Hampson M. Chapter 14 Ethical considerations for fMRI neurofeedback. 2021, 315-331. DOI: 10.1016/b978-0-12-822421-2.00007-7.ChaptersBroader social influencesFMRI neurofeedback trainingHuman brain activityFMRI neurofeedbackNeurofeedback trainingBrain activitySocial influencePersonalized interventionsIndividual participantsPotential ethical concernsNeurofeedbackClinical impairmentProtective frameworkParticipantsCognitionFMRICausal relationshipMore attentionAccessible modalityImpairmentTrainingEthical considerationsEthical concernsEthical issuesPotential benefits