2020
B cell-intrinsic TLR9 expression is protective in murine lupus
Tilstra JS, John S, Gordon RA, Leibler C, Kashgarian M, Bastacky S, Nickerson KM, Shlomchik MJ. B cell-intrinsic TLR9 expression is protective in murine lupus. Journal Of Clinical Investigation 2020, 130: 3172-3187. PMID: 32191633, PMCID: PMC7260024, DOI: 10.1172/jci132328.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Systemic lupus erythematosusTLR9 deficiencyTLR9 expressionDendritic cellsB cellsPlasmacytoid dendritic cellsAnti-nucleosome antibodiesLupus erythematosusAutoantibody productionMurine lupusSLE pathogenesisTLR9 signalsReceptor 9Cell type-specific effectsType-specific effectsDisease pathogenesisTherapeutic potentialSelective deletionDiseaseNonredundant roleNephritisLupusPathogenesisDeficiency
1986
No aggravation of the course of experimental glomerulonephritis in spontaneously hypertensive rats.
Stein H, Sterzel R, Hunt J, Pabst R, Kashgarian M. No aggravation of the course of experimental glomerulonephritis in spontaneously hypertensive rats. American Journal Of Pathology 1986, 122: 520-30. PMID: 3513602, PMCID: PMC1888211.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminuriaAnimalsAntibodies, Anti-IdiotypicAntibody FormationAutoradiographyBlood PressureFluorescent Antibody TechniqueGlomerulonephritisHistocytochemistryHypertensionImmune System DiseasesImmunoglobulin GKidneyMaleMicroscopy, ElectronRabbitsRatsRats, Inbred SHRRats, Inbred WKYThymidineConceptsWistar-Kyoto controlsBlood pressureGBM nephritisRenal injurySystemic hypertensionHypertensive ratsNormotensive Wistar-Kyoto (WKY) controlsAntiglomerular basement membrane nephritisUrinary albumin excretionSystolic blood pressureIgG antibody productionHumoral antibody responseNonspecific esteraseLight microscopyAlbumin excretionAutoregulatory capacityControl SHRMild hypertensionMorphologic injuryCreatinine clearanceGlomerular alterationsSerum creatinineNSE stainingHumoral responseAntibody response