2021
Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data
Moledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrology Dialysis Transplantation 2021, 37: 2214-2222. PMID: 34865148, PMCID: PMC9755995, DOI: 10.1093/ndt/gfab346.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisInterstitial nephritisUrine biomarkersBiopsy-proven acute interstitial nephritisElectronic health record dataExternal validation cohortTypical clinical featuresBlood urea nitrogenTumor necrosis factorCharacteristic curve analysisHealth record dataExternal validationElectronic health recordsAIN diagnosisModest AUCsSerum creatinineCreatinine ratioKidney biopsyClinical featuresValidation cohortNecrosis factorUnrecognized casesInterleukin-9PatientsUrea nitrogen
2020
Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis
Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Nephrology Dialysis Transplantation 2020, 36: 1851-1858. PMID: 33125471, PMCID: PMC8476079, DOI: 10.1093/ndt/gfaa169.Peer-Reviewed Original ResearchConceptsAcute interstitial nephritisTumor necrosis factorCorticosteroid useIL-9Interstitial nephritisNecrosis factorAcute kidney injuryIL-9 levelsGlomerular filtration rateSubset of patientsCohort of participantsImmunosuppressive therapyTubulointerstitial infiltratesKidney injuryMedian eGFRKidney functionUrine biomarkersInterstitial fibrosisFiltration rateHistological featuresClinical trialsInterleukin-9PatientsEGFRComplete data
1998
Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria.
Perazella M, Kashgarian M, Cooney E. Indinavir nephropathy in an AIDS patient with renal insufficiency and pyuria. Clinical Nephrology 1998, 50: 194-6. PMID: 9776425.Peer-Reviewed Original ResearchConceptsRenal biopsy findingsRenal insufficiencyBiopsy findingsMild renal insufficiencyAcute renal failureIndinavir crystalsIndinavir therapyRenal failureAntiretroviral agentsUrinary obstructionAIDS patientsCellular castsPatientsPyuriaInsufficiencyRecent reportsSmall percentDiscontinuationNephropathyMedicationsSecond caseDiuresisNephrolithiasisIndinavirObstruction
1996
The Role of the Kidney Biopsy in the Treatment of Lupus Nephritis
Kashgarian M. The Role of the Kidney Biopsy in the Treatment of Lupus Nephritis. Renal Failure 1996, 18: 765-773. PMID: 8903091, DOI: 10.3109/08860229609047705.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyLupus erythematosusLong-term outcomesCourse of diseaseWorld Health OrganizationMorphologic modalitiesKidney biopsyRenal diseaseRenal histopathologyClinical outcomesRenal lesionsClinical evaluationHistologic classificationClinical correlationImmune responseIndividual patientsSame patientBiopsy interpretationNephritisPatientsBiopsySemiquantitative assessmentDifferent patientsHealth Organization
1992
Clinical significance of renal biopsy in subacute lupus erythematosus
Kashgarian M. Clinical significance of renal biopsy in subacute lupus erythematosus. Transfusion And Apheresis Science 1992, 13: 135-144. PMID: 10148125, DOI: 10.1016/0955-3886(92)90164-c.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyLupus erythematosusSubacute lupus erythematosusCourse of illnessLong-term courseWorld Health OrganizationLupus nephropathyMorphologic modalitiesRenal diseaseRenal histopathologyClinical outcomesRenal lesionsClinical evaluationHistologic classificationClinical correlationClinical significanceImmune responseIndividual patientsSame patientBiopsy interpretationPatientsNephritisSemiquantitative assessmentTerm course
1986
A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia
Seney F, Federgreen W, Stein H, Kashgarian M. A Review of Nephrotic Syndrome Associated With Chronic Lymphocytic Leukemia. JAMA Internal Medicine 1986, 146: 137-141. PMID: 3942445, DOI: 10.1001/archinte.1986.00360130167023.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaNephrotic syndromeLymphocytic leukemiaNephrotic Syndrome AssociatedCommon glomerular lesionImmune complex diseaseRenal diseaseMembranoproliferative glomerulonephritisCellular immunitySyndrome AssociatedGlomerular lesionsImmunoglobulin productionPatientsAvailable evidenceSyndromeLeukemiaDiseaseGlomerulonephritisLesionsImmunity
1985
Lyme arthritis. Spirochetes found in synovial microangiopathic lesions.
Johnston Y, Duray P, Steere A, Kashgarian M, Buza J, Malawista S, Askenase P. Lyme arthritis. Spirochetes found in synovial microangiopathic lesions. American Journal Of Pathology 1985, 118: 26-34. PMID: 3966535, PMCID: PMC1887850.Peer-Reviewed Original ResearchConceptsDieterle silver stainObliterative microvascular lesionsSynovial cell hyperplasiaMicroangiopathic lesionsProminent microvasculatureSynovial stromaMicrovascular injuryMicrovascular lesionsVillous hypertrophySynovial specimensCell hyperplasiaSynovial diseaseEndarteritis obliteransLymphoplasmacellular infiltrationStriking depositionNeedle biopsyStromal depositionLyme spirocheteLyme diseaseBlood vesselsPatientsSilver stainLesionsDiseaseSpirochetes
1981
Wegener's Granulomatosis — Clinical-Pathologic Correlations and Long-Term Course
Appel G, Gee B, Kashgarian M, Hayslett J. Wegener's Granulomatosis — Clinical-Pathologic Correlations and Long-Term Course. American Journal Of Kidney Diseases 1981, 1: 27-37. PMID: 7332000, DOI: 10.1016/s0272-6386(81)80008-x.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseModern immunosuppressive therapyLong-term courseClinical-pathologic entityLong-term reportsImmunosuppressive therapyRenal involvementRenal manifestationsSerum creatinineWegener's granulomatosisRenal diseaseEventual prognosisSingle institutionLight microscopic morphologyPathologic correlationMedical CenterRenal tissueDisease processRespiratory tissuesSpecific diagnosisPotential diagnosisPatientsDiagnosisGranulomatosisBiopsySteroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment
Siegel N, Gaudio K, Krassner L, McDonald B, Anderson F, Kashgarian M. Steroid-dependent nephrotic syndrome in children: Histopathology and relapses after cyclophosphamide treatment. Kidney International 1981, 19: 454-459. PMID: 7241883, DOI: 10.1038/ki.1981.39.Peer-Reviewed Original ResearchConceptsMinimal change lesionSteroid-dependent nephrotic syndromeIncidence of relapseNephrotic syndromeMesangial proliferationSegmental glomerulosclerosisCyclophosphamide treatmentYears of followupTime of treatmentSustained remissionComplete remissionMore relapsesClinical courseHistologic typeHistopathologic typeCyclophosphamidePatientsBiopsy samplesRelapseLesionsSyndromeGlomerulosclerosisRemissionChildrenTreatment
1980
Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor
McLean R, Siegel N, Kashgarian M. Activation of the Classic Complement Pathway in Patients with the C3 Nephritic Factor. Nephron 1980, 25: 57-64. PMID: 6986570, DOI: 10.1159/000181754.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasement MembraneBiopsyCapillariesChildComplement ActivationComplement C3 Nephritic FactorComplement Inactivator ProteinsComplement Pathway, ClassicalFemaleFluorescent Antibody TechniqueGlomerulonephritisHemolysisHumansImmunoelectrophoresis, Two-DimensionalKidneyLipodystrophyMagnesiumMaleMicroscopy, ElectronConceptsC3 nephritic factorNephritic factorPartial lipodystrophyClassic complement pathwayDense deposit diseaseDense intramembranous depositsRenal diseaseDeposit diseaseIntramembranous depositsPatientsFactor assaysComplement pathwayComplement componentsUltrastructural evidenceCurrent criteriaLipodystrophyDiseaseType IHemolytic assayMCGNAssaysThe importance of nonrenal involvement in hemolytic-uremic syndrome.
Upadhyaya K, Barwick K, Fishaut M, Kashgarian M, Siegel N. The importance of nonrenal involvement in hemolytic-uremic syndrome. Pediatrics 1980, 65: 115-20. PMID: 7355005, DOI: 10.1542/peds.65.1.115.Peer-Reviewed Original ResearchThe significance of electron dense deposits in mild lupus nephritis.
Domoto D, Kashgarian M, Hayslett J, Adler M, Siegel N. The significance of electron dense deposits in mild lupus nephritis. The Yale Journal Of Biology And Medicine 1980, 53: 317-24. PMID: 7445538, PMCID: PMC2595828.Peer-Reviewed Original ResearchConceptsMild lupusSubendothelial depositsDiffuse proliferative lesionsPercent of patientsDiffuse proliferative glomerulonephritisRate of progressionElectron-dense depositsLupus nephritisSubsequent biopsyPoor prognosisProliferative glomerulonephritisDeteriorating courseMild lesionsProliferative lesionsPatientsProgressionDense depositsLupusLesionsLight microscopyWide variationGlomerulonephritisNephritisBiopsyPrognosis
1977
SEQUENTIAL HISTOLOGIC CHANGES IN UNTREATED MESANGIALCAPILLARY GLOMERULONEPHRITIS (MCGN)
Siegel N, Kashgarian M. SEQUENTIAL HISTOLOGIC CHANGES IN UNTREATED MESANGIALCAPILLARY GLOMERULONEPHRITIS (MCGN). Pediatric Research 1977, 11: 557-557. DOI: 10.1203/00006450-197704000-01126.Peer-Reviewed Original ResearchInterstitial fibrosisMesangial sclerosisSubendothelial depositsSecond renal biopsyDiffuse mesangial proliferationHistologic improvementSteroid therapyImmunosuppressive agentsRenal biopsyInitial diagnosisMesangial proliferationPatientsSubepithelial depositsSequential histologicSclerosisBasement membraneFibrosisRecent dataSignificant changesProliferationProgressive changesGlomerulonephritisBiopsyHistologicTherapy
1975
Minimal-lesion nephrotic syndrome with early resistance to steroid therapy
Siegel N, Gur A, Krassner L, Kashgarian M. Minimal-lesion nephrotic syndrome with early resistance to steroid therapy. The Journal Of Pediatrics 1975, 87: 377-380. PMID: 1165516, DOI: 10.1016/s0022-3476(75)80639-1.Peer-Reviewed Original ResearchConceptsMinimal lesion nephrotic syndromeNephrotic syndromeLong-term clinical courseEarly resistanceMinimal glomerular lesionsClinical courseSteroid responsivenessClinical outcomesPrompt remissionCyclophosphamide treatmentGlomerular lesionsHistopathologic lesionsPatientsRemissionCyclophosphamideSyndromeTherapyLesionsUltimate outcomeOutcomesChildrenCorticosteroidsPrednisoneRelapseSteroidsClinical Aspects of Bilateral Renal Dysplasia in Children
Gur A, Siegel N, Davis C, Kashgarian M, Hayslett J. Clinical Aspects of Bilateral Renal Dysplasia in Children. Nephron 1975, 15: 50-61. PMID: 236522, DOI: 10.1159/000180492.Peer-Reviewed Original ResearchConceptsBilateral renal dysplasiaRenal dysplasiaClinical featuresClinical aspectsProgressive renal deteriorationLong-term prognosisRenal deteriorationBilateral involvementClinical courseUrinary concentrationsLaurence-MoonBiedl syndromePathogenic mechanismsDysplasiaPaucity of informationPatientsChildrenLarge proportionPrognosisSyndromeImpairment
1974
Clinical spectrum of postpartum renal failure
Finkelstein F, Kashgarian M, Hayslett J. Clinical spectrum of postpartum renal failure. The American Journal Of Medicine 1974, 57: 649-654. PMID: 4432867, DOI: 10.1016/0002-9343(74)90019-9.Peer-Reviewed Original ResearchConceptsPostpartum renal failureRenal failureFibrin depositionExtensive fibrin depositionFulminant renal failureMinor renal dysfunctionRenal functional abnormalitiesSpectrum of diseaseRenal dysfunctionFatal courseClinical spectrumPostpartum periodRenal abnormalitiesRenal vasculatureFunctional abnormalitiesPatientsAbnormalitiesFailureDysfunctionDiseaseVasculatureSHWARTZMAN REACTION IN AN HL-A-IDENTICAL RENAL ALLOGRAFT
SCHIFF M, GOFFINET J, HENDLER E, RUDDLE N, Kashgarian M, LYTTON B. SHWARTZMAN REACTION IN AN HL-A-IDENTICAL RENAL ALLOGRAFT. Transplantation 1974, 17: 580-583. PMID: 4208389, DOI: 10.1097/00007890-197406000-00006.Peer-Reviewed Original ResearchConceptsShwartzman reactionDiffuse intravascular coagulationIdentical sibling donorsEvidence of sensitizationAntigen mismatchesRenal allograftsIntravascular coagulationKidney transplantSibling donorsNegative bacteremiaHistological examinationSkin transplantationIrreversible cessationSame donorTransplantAllograftsPatientsTransplantationKidneyBacteremiaSteroidsDonorsAntibodiesSensitizationCessationCYCLOPHOSPHAMIDE IN THE TREATMENT OF STEROID-RESISTANT MINIMAL-CHANGE NEPHROTIC SYNDROME
Siegel N, Gur A, Krassner L, Kashgarian M, Cook C. CYCLOPHOSPHAMIDE IN THE TREATMENT OF STEROID-RESISTANT MINIMAL-CHANGE NEPHROTIC SYNDROME. Pediatric Research 1974, 8: 461-461. DOI: 10.1203/00006450-197404000-00724.Peer-Reviewed Original ResearchNephrotic syndromeComplete remissionSteroid-resistant minimal change nephrotic syndromeMinimal change nephrotic syndromeSteroid-resistant nephrotic syndromeCourses of cyclophosphamideMinimal change lesionChange nephrotic syndromeTreatment of childrenSteroid therapyGonadal toxicityInitial treatmentSuch therapyCyclophosphamideWeek courseSyndromeLittle dataPrednisoneRemissionTreatmentPatientsChildrenTherapyGlucosteroidsRelapse
1972
CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA
Hendler E, Kashgarian M, Hayslett J. CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA. The Lancet 1972, 299: 458-463. PMID: 4109816, DOI: 10.1016/s0140-6736(72)90121-3.Peer-Reviewed Original ResearchConceptsRenal diseaseProliferative glomerulonephritisPathological lesionsMild proliferative glomerulonephritisUrinary tract lesionsUrinary protein excretionGroup of patientsTypes of glomerulonephritisSevere proliferative glomerulonephritisType of lesionIntercurrent infectionRenal functionRenal biopsyProtein excretionPrimary lesionClinicopathological correlationDistribution of ageCorrect diagnosisPatientsGlomerulonephritisLesionsYoung adultsDiseaseHæmorrhageUseful index
1971
Effect of azathioprine in patients with lupus glomerulonephritis
Hayslett J, Cook C, Kashgarian M, Spargo B. Effect of azathioprine in patients with lupus glomerulonephritis. Pediatric Research 1971, 5: 384-385. DOI: 10.1203/00006450-197108000-00058.Peer-Reviewed Original ResearchSevere glomerulonephritisRenal failureLupus glomerulonephritisNephrotic syndromeRenal lesionsMonths of therapyEvidence of progressionSevere renal failureMonths of treatmentEffect of azathioprinePatient's proteinuriaMembranous nephropathySevere nephritisHistological featuresIntensive treatmentMembranous changesGlomerulonephritisInexorable progressionProliferative lesionsPatientsLow dosesLesionsStriking decreaseAzathioprineMonths