2024
Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial
Brown J, Spielmann G, Yang S, Compton S, Jones L, Irwin M, Ligibel J, Meyerhardt J. Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1520-1527. PMID: 38887915, PMCID: PMC11294014, DOI: 10.1002/jcsm.13509.Peer-Reviewed Original ResearchAerobic exerciseMyokine concentrationsStage I-III breastColorectal cancer survivorsEffects of exerciseColorectal cancerLinear mixed-effects regression modelsMixed-effects regression modelsCancer survivorsPhysical activityType I error rateExerciseMyokinesPilot studyRegression modelsCancer patientsRandomized trialsHypothesis-generating analysisMultiple comparisonsBreastSkeletal muscleInterleukin-15Clinical outcomesCancerPatients
2021
Effect of exercise on peritoneal microenvironment and progression of ovarian cancer.
Morrisson M, Bi F, Yang K, Cady S, Hartwich T, Cerchia A, Li Z, Kim J, Irwin M, Yang-Hartwich Y. Effect of exercise on peritoneal microenvironment and progression of ovarian cancer. American Journal Of Cancer Research 2021, 11: 5045-5062. PMID: 34765311, PMCID: PMC8569339.Peer-Reviewed Original ResearchEffects of exerciseOvarian cancerPeritoneal microenvironmentChemotherapy outcomesPatients' health-related qualityBlood urea nitrogen levelsMouse ovarian cancer modelIncidence of neutropeniaIntraperitoneal fat tissueProduction of CCL2Role of CCL2Health-related qualityDeadliest gynecological malignancyMetastatic ovarian cancerExercise-induced changesUrea nitrogen levelsOvarian cancer modelOvarian carcinoma progressionPotential beneficial effectsCancer cell viabilityPeritoneal colonizationCo-culture modelChronic exerciseClinical outcomesGynecological malignancies
2020
Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial
Brown JC, Zhang S, Ligibel JA, Irwin ML, Jones LW, Campbell N, Pollak MN, Sorrentino A, Cartmel B, Harrigan M, Tolaney SM, Winer EP, Ng K, Abrams TA, Sanft T, Douglas PS, Hu FB, Fuchs CS, Meyerhardt JA. Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial. Cancer Prevention Research 2020, 13: 1055-1062. PMID: 32859615, PMCID: PMC7718298, DOI: 10.1158/1940-6207.capr-20-0188.Peer-Reviewed Original ResearchConceptsHs-CRPColorectal cancerPhysical activityHigh-sensitivity C-reactive proteinLow baseline physical activitySurvivors of breastTrial product estimandBaseline physical activityBiomarkers of inflammationC-reactive proteinMeasures of inflammationImproved clinical outcomesEffects of exerciseType 2 diabetesCombination of exerciseStandard therapyClinical outcomesCancer recurrenceObservational studyTreatment groupsInflammation outcomesMetforminIL6Factorial trialInflammation