2023
Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeIntervention
2021
Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer
Lisevick A, Cartmel B, Harrigan M, Li F, Sanft T, Fogarasi M, Irwin ML, Ferrucci LM. Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer. Nutrients 2021, 13: 3265. PMID: 34579142, PMCID: PMC8469752, DOI: 10.3390/nu13093265.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsLong-term weight loss maintenanceUsual care groupWeight loss maintenanceCancer survivorsStudy completionCare groupLoss maintenanceWeight lossBody weightLong-term weight maintenanceShort-term weight lossLong-term weight gainModest weight lossOverweight/obesityElectronic health recordsLifestyle interventionWeight maintenanceBreast cancerWeight trajectoriesWeight gainCurve analysisNutrition studiesWeight changeHealth recordsRandomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
Puklin L, Cartmel B, Harrigan M, Lu L, Li FY, Sanft T, Irwin ML. Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors. Npj Breast Cancer 2021, 7: 49. PMID: 33976224, PMCID: PMC8113314, DOI: 10.1038/s41523-021-00260-6.Peer-Reviewed Original ResearchBreast cancer survivorsBody mass indexCancer survivorsGhrelin levelsLifestyle interventionUsual careWeight lossPg/Higher ghrelin levelsWeight loss interventionLean body massSix-month changesGreater weight lossWeight regainLoss interventionStudy armsMass indexWeight maintenanceBlood biomarkersHormone ghrelinBlood samplesGhrelinBody compositionBody weightBaseline associations
2015
Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis
Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. Journal Of The National Cancer Institute 2015, 107: djv275. PMID: 26424778, PMCID: PMC4715249, DOI: 10.1093/jnci/djv275.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer-specific mortalityCancer-specific mortalityCause mortalityWeight gainBreast cancer diagnosisBreast cancerStage I-IIIC breast cancerSystematic reviewPrediagnosis body mass indexWomen age 18 yearsPostdiagnosis weight gainCancer diagnosisCause mortality ratesBreast cancer mortalityAge 18 yearsWeb of ScienceCohort studyRecurrence outcomesMass indexCancer mortalityClinical trialsHigh riskMortality rateBody weight
2010
Physical Activity, Weight Control, and Cancer Prognosis
Schmitz K, Irwin M, Speck R. Physical Activity, Weight Control, and Cancer Prognosis. Energy Balance And Cancer 2010, 165-182. DOI: 10.1007/978-1-4419-7551-5_8.Peer-Reviewed Original ResearchPhysical activityExercise programCancer prognosisWeight controlMortality of cancerMajority of evidenceGastric cardiaCancer survivorsPoor prognosisBreast cancerBody weightColon cancerPrognosisCancerCancer treatmentWeight lossCancer diagnosisDiagnosisPatientsPersistent effectsEvidenceObesityCardiaEndometriumRecurrence
2003
Physical activity levels before and after a diagnosis of breast carcinoma
Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard‐Barbash R. Physical activity levels before and after a diagnosis of breast carcinoma. Cancer 2003, 97: 1746-1757. PMID: 12655532, PMCID: PMC3034406, DOI: 10.1002/cncr.11227.Peer-Reviewed Original ResearchConceptsBody mass indexPhysical activityBreast carcinomaIncident breast carcinomaPopulation-based studyRisk of recurrenceTotal physical activitySport physical activityPrediagnosis levelsAdjuvant treatmentPatient ageMass indexType of sportAdverse outcomesDisease stageTime patientsBaseline interviewBody weightPA levelsWeight gainPatientsDiagnosisCarcinomaWomenChemotherapyEffect of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial
Irwin ML, Yasui Y, Ulrich CM, Bowen D, Rudolph RE, Schwartz RS, Yukawa M, Aiello E, Potter JD, McTiernan A. Effect of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial. JAMA 2003, 289: 323-330. PMID: 12525233, DOI: 10.1001/jama.289.3.323.Peer-Reviewed Original ResearchConceptsSubcutaneous abdominal fatBody fat lossEffects of exercisePostmenopausal womenBody fatBody weightHome-based moderate-intensity exerciseAbdominal fatFat lossGreater body fat lossMajor public health concernSports/recreational activitiesObese postmenopausal womenIntra-abdominal fatPrevalence of obesityReduced body weightDuration of exerciseMin/wkModerate-intensity exerciseSignificant dose responseTotal body fatLevel of exerciseTwelve-month dataPublic health concernExercise group
2002
Exercise Effect on Body Weight in Postmenopausal Women: The Physical Activity for Total Health Study
Irwin M, McTiernan A. Exercise Effect on Body Weight in Postmenopausal Women: The Physical Activity for Total Health Study. Medical Science Symposia Series 2002, 17: 345-352. DOI: 10.1007/978-1-4615-1061-1_41.Peer-Reviewed Original ResearchTotal Health studyPrevalence of overweightAdult American populationObese 1Postmenopausal womenObesity comorbiditiesCardiovascular diseasePhysical activitySedentary lifestyleHealth StudyBody weightOlder personsCertain cancersOverweightObesityPrevalenceLevel 4American populationHypertensionComorbiditiesDiabetesStrokeCancerDiseaseWomen
2001
Estimation of Energy Expenditure from Physical Activity Measures: Determinants of Accuracy
Irwin M, Ainsworth B, Conway J. Estimation of Energy Expenditure from Physical Activity Measures: Determinants of Accuracy. Obesity 2001, 9: 517-525. PMID: 11557832, DOI: 10.1038/oby.2001.68.Peer-Reviewed Original ResearchConceptsBody fatPA recordsEnergy expenditureOverestimation of EESeven-Day Physical Activity RecallEstimation of EEMen 50 yearsBody mass indexHigher body fatnessPhysical activity levelsPhysical activity measuresPhysical activity recallYears of agePA assessment methodsEstimates of EEMass indexActivity recallBody fatnessBody weightOlder agePA levelsActivity measuresPA behaviorAdditional studiesPA measures
2000
Compendium of Physical Activities: an update of activity codes and MET intensities
AINSWORTH B, HASKELL W, WHITT M, IRWIN M, SWARTZ A, STRATH S, O’BRIEN W, BASSETT D, SCHMITZ K, EMPLAINCOURT P, JACOBS D, LEON A. Compendium of Physical Activities: an update of activity codes and MET intensities. Medicine & Science In Sports & Exercise 2000, 32: s498-s516. PMID: 10993420, DOI: 10.1097/00005768-200009001-00009.Peer-Reviewed Original Research