Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes
Fazel Darbandi S, An J, Lim K, Page N, Liang L, Young D, Ypsilanti A, State M, Nord A, Sanders S, Rubenstein J. Five autism-associated transcriptional regulators target shared loci proximal to brain-expressed genes. Cell Reports 2024, 43: 114329. PMID: 38850535, PMCID: PMC11235582, DOI: 10.1016/j.celrep.2024.114329.Peer-Reviewed Original ResearchBrain-expressed genesTranscriptional regulationChromatin immunoprecipitation sequencingTranscription start siteASD-associated genesChIP-seqImmunoprecipitation sequencingStart sitePromoter regionMouse cortical culturesRegulatory targetsGenesPostmortem brain samplesFunctional convergenceBinding sitesTranscriptomic signaturesChromatinARID1BBrain samplesCortical culturesRegulationTbr1Mouse cortexCRISPRiCells