2016
The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity
Jeffery E, Wing A, Holtrup B, Sebo Z, Kaplan JL, Saavedra-Peña R, Church CD, Colman L, Berry R, Rodeheffer MS. The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity. Cell Metabolism 2016, 24: 142-150. PMID: 27320063, PMCID: PMC4945385, DOI: 10.1016/j.cmet.2016.05.012.Peer-Reviewed Original ResearchConceptsVisceral white adipose tissueHigh-fat dietAdipose tissueAdipocyte precursorsAdipocyte hyperplasiaDepot-specific adipogenesisDifferential fat distributionObesity-associated pathologiesWhite adipose tissueAdipose tissue microenvironmentSubcutaneous adipose tissueAdipose tissue growthCell-intrinsic mechanismsMetabolic healthFat distributionMale miceHormone-dependent mannerDimorphic distributionObesityHyperplasiaAdipogenesisTissue microenvironmentTissueMicroenvironmentPlastic cells
2015
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
Jeffery E, Church CD, Holtrup B, Colman L, Rodeheffer MS. Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity. Nature Cell Biology 2015, 17: 376-385. PMID: 25730471, PMCID: PMC4380653, DOI: 10.1038/ncb3122.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytes, WhiteAdipogenesisAdipose Tissue, WhiteAndrostadienesAnimalsCell ProliferationDiet, High-FatEatingMaleMiceMice, Inbred C57BLMice, KnockoutObesityPhosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProto-Oncogene Proteins c-aktRandom AllocationTamoxifenWortmanninConceptsWhite adipose tissueAdipocyte precursorsMolecular mechanismsWAT growthNew adipocytesHigh-fat diet feedingCharacteristics of obesityOnset of obesityDistinct molecular mechanismsActivation of adipogenesisAdipocyte precursor cellsWAT massVisceral depotsDiet feedingMale miceAdipose tissueObesityAkt2 pathwayMature adipocytesPrecursor cellsAdipogenesisAdipocytesExcessive accumulationMiceActivation
2013
Weighing in on Adipocyte Precursors
Berry R, Jeffery E, Rodeheffer MS. Weighing in on Adipocyte Precursors. Cell Metabolism 2013, 19: 8-20. PMID: 24239569, PMCID: PMC3947170, DOI: 10.1016/j.cmet.2013.10.003.Peer-Reviewed Original Research
2008
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer MS, Birsoy K, Friedman JM. Identification of White Adipocyte Progenitor Cells In Vivo. Cell 2008, 135: 240-249. PMID: 18835024, DOI: 10.1016/j.cell.2008.09.036.Peer-Reviewed Original ResearchConceptsAdipocyte progenitor cellsWhite adipocyte progenitor cellsWhite adipose tissue massProgenitor cellsAdipose tissue massHypertrophy of adipocytesAdipose tissue stromaLipodystrophic miceWAT depotsDiabetic phenotypeAdipocyte numberAdipose depotsCells residentTissue massFat padTissue stromaNoninvasive assayVivoCellsReportObesityHyperplasiaDepotsHypertrophyMice