2016
The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity
Jeffery E, Wing A, Holtrup B, Sebo Z, Kaplan JL, Saavedra-Peña R, Church CD, Colman L, Berry R, Rodeheffer MS. The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity. Cell Metabolism 2016, 24: 142-150. PMID: 27320063, PMCID: PMC4945385, DOI: 10.1016/j.cmet.2016.05.012.Peer-Reviewed Original ResearchConceptsVisceral white adipose tissueHigh-fat dietAdipose tissueAdipocyte precursorsAdipocyte hyperplasiaDepot-specific adipogenesisDifferential fat distributionObesity-associated pathologiesWhite adipose tissueAdipose tissue microenvironmentSubcutaneous adipose tissueAdipose tissue growthCell-intrinsic mechanismsMetabolic healthFat distributionMale miceHormone-dependent mannerDimorphic distributionObesityHyperplasiaAdipogenesisTissue microenvironmentTissueMicroenvironmentPlastic cells
2008
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer MS, Birsoy K, Friedman JM. Identification of White Adipocyte Progenitor Cells In Vivo. Cell 2008, 135: 240-249. PMID: 18835024, DOI: 10.1016/j.cell.2008.09.036.Peer-Reviewed Original ResearchConceptsAdipocyte progenitor cellsWhite adipocyte progenitor cellsWhite adipose tissue massProgenitor cellsAdipose tissue massHypertrophy of adipocytesAdipose tissue stromaLipodystrophic miceWAT depotsDiabetic phenotypeAdipocyte numberAdipose depotsCells residentTissue massFat padTissue stromaNoninvasive assayVivoCellsReportObesityHyperplasiaDepotsHypertrophyMice