2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2020
Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients
Gaston DC, Malinis M, Osborn R, Peaper DR, Landry M, Juthani-Mehta M, Azar MM. Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients. American Journal Of Transplantation 2020, 21: 1304-1311. PMID: 33043603, PMCID: PMC7675520, DOI: 10.1111/ajt.16357.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsClinical implicationsCycle threshold valuesSOT patientsTransplant recipientsSymptom onsetYale New Haven Health SystemUpper respiratory tract samplesSARS-CoV-2 viral RNASARS-CoV-2 viral dynamicsAdult SOT recipientsRetrospective chart reviewRespiratory tract samplesSARS-CoV-2 cycle threshold valuesInfection prevention measuresCOVID-19 severityViral RNAHigher clinical acuityPrimary diagnostic testRT-PCR assaysSOT recipientsChart reviewViral loadAdmission severityNanima
Juthani-Mehta M. Nanima. New England Journal Of Medicine 2020, 384: 1488-1489. PMID: 33108099, DOI: 10.1056/nejmp2028693.Peer-Reviewed Original ResearchEducation needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey
Datta R, Topal J, McManus D, Sanft T, Dembry LM, Morrison LJ, Quagliarello V, Juthani-Mehta M. Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey. Palliative Medicine 2020, 35: 236-241. PMID: 32928066, DOI: 10.1177/0269216320956811.Peer-Reviewed Original ResearchConceptsEscalation of careAdvance care planningLife careAdvanced cancerCross-sectional surveyIntravenous antimicrobialsOlder adultsAntimicrobial useCare planningSingle-center cross-sectional surveyEducational interventionAdvance care plansRole of antimicrobialsClinical deteriorationPercent of respondentsAdverse eventsOral antimicrobialsMedicine subspecialistsCare plansInpatient medicineCareCancerPatientsAdultsSubspecialistsInconsistent Addiction Treatment for Patients Undergoing Cardiac Surgery for Injection Drug Use-associated Infective Endocarditis.
Nguemeni Tiako MJ, Hong S, Bin Mahmood SU, Mori M, Mangi A, Yun J, Juthani-Mehta M, Geirsson A. Inconsistent Addiction Treatment for Patients Undergoing Cardiac Surgery for Injection Drug Use-associated Infective Endocarditis. Journal Of Addiction Medicine 2020, 14: e350-e354. PMID: 32732685, DOI: 10.1097/adm.0000000000000710.Peer-Reviewed Original ResearchConceptsActive drug useInjection drug use-associated infective endocarditisOpioid use disorderPsychosocial consultationAddiction treatmentDrug rehabilitation programInfective endocarditisRehabilitation programUse disordersDrug use-associated infective endocarditisDrug useEvidence of enrollmentTertiary care centerInjection drug useUS opioid epidemicDrug rehabilitationRehabilitation attendanceMost patientsCardiac surgeryRetrospective reviewCare centerOpioid epidemicPatientsMedicationsIDUsRepurposing antimicrobial stewardship tools in the electronic medical record for the management of COVID-19 patients
Davis MW, McManus D, Koff A, Jaszczur GR, Malinis M, Dela Cruz C, Britto CJ, Price C, Azmy V, Kaman K, Gaston D, Early K, DeWitt M, Song JS, Ortiz C, Juthani-Mehta M, Topal JE. Repurposing antimicrobial stewardship tools in the electronic medical record for the management of COVID-19 patients. Infection Control And Hospital Epidemiology 2020, 41: 1335-1337. PMID: 32507113, PMCID: PMC7308631, DOI: 10.1017/ice.2020.281.Peer-Reviewed Original Research
2019
Involving Physicians-in-Training in the Care of Patients During Epidemics
Pepe D, Martinello RA, Juthani-Mehta M. Involving Physicians-in-Training in the Care of Patients During Epidemics. Journal Of Graduate Medical Education 2019, 11: 632-634. PMID: 31871560, PMCID: PMC6919171, DOI: 10.4300/jgme-d-19-00354.1.Peer-Reviewed Original ResearchPerspectives on antimicrobial use at the end of life among antibiotic stewardship programs: A survey of the Society for Healthcare Epidemiology of America Research Network
Datta R, Topal J, McManus D, Dembry LM, Quagliarello V, Juthani-Mehta M. Perspectives on antimicrobial use at the end of life among antibiotic stewardship programs: A survey of the Society for Healthcare Epidemiology of America Research Network. Infection Control And Hospital Epidemiology 2019, 40: 1074-1076. PMID: 31328703, PMCID: PMC7165360, DOI: 10.1017/ice.2019.194.Peer-Reviewed Original ResearchIncreased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: 1611-1615. PMID: 31506700, DOI: 10.1093/cid/ciz021.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenAntibiotic-sparing agents for uncomplicated cystitis: uva-ursi and ibuprofen not ready for primetime
Datta R, Juthani-Mehta M. Antibiotic-sparing agents for uncomplicated cystitis: uva-ursi and ibuprofen not ready for primetime. Clinical Microbiology And Infection 2019, 25: 922-924. PMID: 31035018, PMCID: PMC6612576, DOI: 10.1016/j.cmi.2019.04.022.Commentaries, Editorials and LettersClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: e83-e110. PMID: 30895288, DOI: 10.1093/cid/ciy1121.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfectionOlder men may benefit from antimicrobial prophylaxis for recurrent urinary tract infections
Mody L, Juthani-Mehta M. Older men may benefit from antimicrobial prophylaxis for recurrent urinary tract infections. Age And Ageing 2019, 48: 167-168. PMID: 30715095, DOI: 10.1093/ageing/afy195.Peer-Reviewed Original Research
2018
Uncomplicated Cystitis in Nursing Home Residents: A Practical Guide to Diagnosis and Management
Datta R, Juthani-Mehta M. Uncomplicated Cystitis in Nursing Home Residents: A Practical Guide to Diagnosis and Management. Journal Of The American Medical Directors Association 2018, 19: 733-735. PMID: 30149841, PMCID: PMC6510384, DOI: 10.1016/j.jamda.2018.07.015.Commentaries, Editorials and LettersNitrofurantoin vs Fosfomycin: Rendering a Verdict in a Trial of Acute Uncomplicated Cystitis
Datta R, Juthani-Mehta M. Nitrofurantoin vs Fosfomycin: Rendering a Verdict in a Trial of Acute Uncomplicated Cystitis. JAMA 2018, 319: 1771-1772. PMID: 29710273, PMCID: PMC6565436, DOI: 10.1001/jama.2018.4654.Commentaries, Editorials and Letters
2017
Antimicrobial Use at the End of Life
Baghban A, Juthani-Mehta M. Antimicrobial Use at the End of Life. Infectious Disease Clinics Of North America 2017, 31: 639-647. PMID: 29079153, DOI: 10.1016/j.idc.2017.07.009.Peer-Reviewed Original ResearchCranberry Capsules for bacteriuria Plus Pyuria in Nursing Home Residents—Reply
Juthani-Mehta M, Van Ness PH, Peduzzi P. Cranberry Capsules for bacteriuria Plus Pyuria in Nursing Home Residents—Reply. JAMA 2017, 317: 1078-1079. PMID: 28291888, DOI: 10.1001/jama.2017.0092.Peer-Reviewed Original Research
2016
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial
Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA 2016, 316: 1879-1887. PMID: 27787564, PMCID: PMC5300771, DOI: 10.1001/jama.2016.16141.Peer-Reviewed Original ResearchConceptsUrinary tract infectionPresence of bacteriuriaSymptomatic urinary tract infectionCranberry capsulesNursing homesOlder womenTreatment groupsControl groupPlacebo-controlled efficacy trialSignificant differencesRate of deathAntibiotic-resistant organismsControl group participantsCause deathStudy surveillanceCause hospitalizationSecondary outcomesTract infectionsPrimary outcomeOverall adherenceAntimicrobial utilizationClinical trialsEfficacy trialsPyuriaUnadjusted resultsStatus of the Prevention of Multidrug-Resistant Organisms in International Settings: A Survey of the Society for Healthcare Epidemiology of America Research Network
Safdar N, Sengupta S, Musuuza JS, Juthani-Mehta M, Drees M, Abbo LM, Milstone AM, Furuno JP, Varman M, Anderson DJ, Morgan DJ, Miller LG, Snyder GM. Status of the Prevention of Multidrug-Resistant Organisms in International Settings: A Survey of the Society for Healthcare Epidemiology of America Research Network. Infection Control And Hospital Epidemiology 2016, 38: 53-60. PMID: 27817759, DOI: 10.1017/ice.2016.242.Peer-Reviewed Original Research