2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2020
Nanima
Juthani-Mehta M. Nanima. New England Journal Of Medicine 2020, 384: 1488-1489. PMID: 33108099, DOI: 10.1056/nejmp2028693.Peer-Reviewed Original Research
2019
Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2016
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial
Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA 2016, 316: 1879-1887. PMID: 27787564, PMCID: PMC5300771, DOI: 10.1001/jama.2016.16141.Peer-Reviewed Original ResearchConceptsUrinary tract infectionPresence of bacteriuriaSymptomatic urinary tract infectionCranberry capsulesNursing homesOlder womenTreatment groupsControl groupPlacebo-controlled efficacy trialSignificant differencesRate of deathAntibiotic-resistant organismsControl group participantsCause deathStudy surveillanceCause hospitalizationSecondary outcomesTract infectionsPrimary outcomeOverall adherenceAntimicrobial utilizationClinical trialsEfficacy trialsPyuriaUnadjusted results
2015
Antibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo
Madden GR, Argraves SM, Van Ness PH, Juthani-Mehta M. Antibiotic Susceptibility of Urinary Isolates in Nursing Home Residents Consuming Cranberry Capsules Versus Placebo. Infection Control And Hospital Epidemiology 2015, 36: 356-357. PMID: 25695180, PMCID: PMC4336946, DOI: 10.1017/ice.2014.66.Peer-Reviewed Original Research
2014
A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders
Juthani-Mehta M, Van Ness PH, McGloin J, Argraves S, Chen S, Charpentier P, Miller L, Williams K, Wall D, Baker D, Tinetti M, Peduzzi P, Quagliarello VJ. A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders. Clinical Infectious Diseases 2014, 60: 849-857. PMID: 25520333, PMCID: PMC4415071, DOI: 10.1093/cid/ciu935.Peer-Reviewed Original ResearchConceptsNursing home residentsUsual careHome residentsIntervention protocolFirst pneumoniaControl armClinical trialsNursing homesMultivariable Cox regression modelsElderly nursing home residentsCluster-randomized clinical trialImportant public health problemChlorhexidine oral rinseModifiable risk factorsRespiratory tract infectionsCox regression modelNursing home eldersPublic health problemHazard ratioPneumonia preventionSecondary outcomesTract infectionsControlled TrialsPrimary outcomeOral rinseTests for Urinary Tract Infection in Nursing Home Residents
Juthani-Mehta M, Datunashvili A, Tinetti M. Tests for Urinary Tract Infection in Nursing Home Residents. JAMA 2014, 312: 1687-1688. PMID: 25335152, DOI: 10.1001/jama.2014.13554.Peer-Reviewed Original Research
2013
Lack of Positive Association Between Falls and Bacteriuria Plus Pyuria in Older Nursing Home Residents
Rowe T, Towle V, Van Ness P, Juthani‐Mehta M. Lack of Positive Association Between Falls and Bacteriuria Plus Pyuria in Older Nursing Home Residents. Journal Of The American Geriatrics Society 2013, 61: 653-654. PMID: 23581923, PMCID: PMC3628627, DOI: 10.1111/jgs.12177.Peer-Reviewed Original Research
2011
Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. PMID: 21091203, PMCID: PMC3089439, DOI: 10.1086/657664.Peer-Reviewed Original Research
2010
Infectious Diseases in the Nursing Home Setting: Challenges and Opportunities for Clinical Investigation
High K, Juthani-Mehta M, Quagliarello V. Infectious Diseases in the Nursing Home Setting: Challenges and Opportunities for Clinical Investigation. Clinical Infectious Diseases 2010, 51: 931-936. PMID: 20822459, PMCID: PMC3083824, DOI: 10.1086/656411.Peer-Reviewed Original ResearchConceptsNursing home residentsHome residentsInfectious diseasesNursing homesNursing home settingMultiple comorbid diseasesPublic health problemComorbid diseasesHigh prevalenceFunctional declineClinical investigationPhysician investigatorsHealth problemsDiseaseHome settingOlder AmericansUnique issuesResidentsImmunosenescencePrognosisDementiaInfectionPrevalenceDiagnosis
2009
Antimicrobial Susceptibility of Bacteria Isolated from Urine Samples Obtained from Nursing Home Residents
Das R, Perrelli E, Towle V, Van Ness PH, Juthani-Mehta M. Antimicrobial Susceptibility of Bacteria Isolated from Urine Samples Obtained from Nursing Home Residents. Infection Control And Hospital Epidemiology 2009, 30: 1116-1119. PMID: 19785518, PMCID: PMC2866029, DOI: 10.1086/647981.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAnti-Bacterial AgentsDrug Resistance, BacterialEnterobacteriaceaeEnterobacteriaceae InfectionsEscherichia coliEscherichia coli InfectionsFemaleHomes for the AgedHumansMaleMicrobial Sensitivity TestsNitrofurantoinNursing HomesTrimethoprim, Sulfamethoxazole Drug CombinationUrinary Tract InfectionsUrineConceptsUrinary tract infectionNursing home residentsTract infectionsHome residentsUrine samplesEmpiric antimicrobial therapyOral antibioticsAntibiotic therapyIndwelling catheterTrimethoprim-sulfamethoxazoleAntimicrobial therapyResistance patternsAntimicrobial susceptibilityPredominant organismTherapyInfectionResidentsCatheterNitrofurantoinPilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents
Quagliarello V, Juthani‐Mehta M, Ginter S, Towle V, Allore H, Tinetti M. Pilot Testing of Intervention Protocols to Prevent Pneumonia in Nursing Home Residents. Journal Of The American Geriatrics Society 2009, 57: 1226-1231. PMID: 19558483, PMCID: PMC2779042, DOI: 10.1111/j.1532-5415.2009.02311.x.Peer-Reviewed Original ResearchConceptsNursing home residentsChlorhexidine oral rinseOral brushingHome residentsOral hygieneStaff adherenceOral rinseIntervention protocolImproved oral hygienePneumonia risk factorsRisk factor reductionPlaque score reductionPrevent PneumoniaChlorhexidine rinseProspective studyRisk factorsScore reductionNursing homesSwallowing techniquesAdherenceBrushingFactor reductionPneumoniaHygieneMonthsClinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study
Juthani‐Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study. Journal Of The American Geriatrics Society 2009, 57: 963-970. PMID: 19490243, PMCID: PMC2692075, DOI: 10.1111/j.1532-5415.2009.02227.x.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overBacteriuriaCohort StudiesDysuriaFemaleHumansMaleNursing HomesPyuriaUrinalysisUrinary Tract InfectionsUrineConceptsUrinary tract infectionNursing home residentsClinical featuresHome residentsCohort studyTract infectionsMental statusPresence of dysuriaObservational cohort studyArea nursing homesUrine culturePyuriaClinical definitionBacteriuriaHigh riskLower riskDiagnostic uncertaintyNursing homesCombined outcomeDysuriaInfectionUrineOutcomesEpisodesRisk
2008
Interobserver Variability in the Assessment of Clinical Criteria for Suspected Urinary Tract Infection in Nursing Home Residents
Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Interobserver Variability in the Assessment of Clinical Criteria for Suspected Urinary Tract Infection in Nursing Home Residents. Infection Control And Hospital Epidemiology 2008, 29: 446-449. PMID: 18419369, PMCID: PMC2671070, DOI: 10.1086/586721.Peer-Reviewed Original Research
2007
Asymptomatic Bacteriuria and Urinary Tract Infection in Older Adults
Juthani-Mehta M. Asymptomatic Bacteriuria and Urinary Tract Infection in Older Adults. Clinics In Geriatric Medicine 2007, 23: 585-594. PMID: 17631235, DOI: 10.1016/j.cger.2007.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnti-Infective Agents, UrinaryBacteriuriaGlobal HealthHumansMorbidityPrognosisRisk FactorsUrinary Tract InfectionsDiagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*
Juthani‐Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Diagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*. Journal Of The American Geriatrics Society 2007, 55: 1072-1077. PMID: 17608881, DOI: 10.1111/j.1532-5415.2007.01217.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsNegative predictive valuePositive predictive valueConsensus-based criteriaLaboratory evidenceHome residentsTract infectionsPredictive valueEvidence-based clinical criteriaDiagnostic accuracyProspective cohort studySimilar test characteristicsMcGeer criteriaUTI criteriaCohort studyProspective surveillanceUrine cultureClinical criteriaNursing homesTest characteristicsInfectionLoeb criteriaParticipantsSpecificity
2005
Nursing Home Practitioner Survey of Diagnostic Criteria for Urinary Tract Infections
Juthani‐Mehta M, Drickamer MA, Towle V, Zhang Y, Tinetti ME, Quagliarello VJ. Nursing Home Practitioner Survey of Diagnostic Criteria for Urinary Tract Infections. Journal Of The American Geriatrics Society 2005, 53: 1986-1990. PMID: 16274383, DOI: 10.1111/j.1532-5415.2005.00470.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsTract infectionsLaboratory criteriaHome residentsDiagnostic criteriaClinical practiceConsensus criteriaInfection control practitionersFirst diagnostic stepMcGeer criteriaNoncatheterized patientsUrine cultureProspective dataMental statusNineteen physiciansSurveillance criteriaNursing homesPrevention strategiesSelf-administered surveyDipstick analysisDiagnostic stepsPhysician assistantsCharge nursesNurses
2004
Prognostic Scoring Systems for Infectious Diseases: Their Applicability to the Care of Older Adults
High K, Juthani-Mehta M, Quagliarello V. Prognostic Scoring Systems for Infectious Diseases: Their Applicability to the Care of Older Adults. Clinical Infectious Diseases 2004, 38: 692-696. PMID: 14986254, DOI: 10.1086/381688.Peer-Reviewed Original ResearchConceptsPrognostic scoring systemOlder adultsScoring systemAdult populationInfectious diseasesPrimary end pointNumber of patientsGeneral adult populationHealth care needsHealth care costsHeterogeneous adult populationClinical outcomesBloodstream infectionsIndividual patientsCare needsCare costsRelevant outcomesEnd pointClinical predictionDiseasePatientsAdultsFurther investigationCareOutcomes