2024
Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia
Lee S, Benson J, Cohen A, Quagliarello V, Juthani-Mehta M, Datta R. Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia. Antimicrobial Stewardship & Healthcare Epidemiology 2024, 4: e48. PMID: 38655023, PMCID: PMC11036428, DOI: 10.1017/ash.2024.54.Peer-Reviewed Original ResearchNon-ventilator hospital-acquired pneumoniaAdvanced cancerPalliative care settingHospital-acquired pneumoniaCohort study of patientsCare settingsOlder adultsAdjusted oddsDuration of antibiotic therapyAssociated with reduced adjusted oddsSingle-center observational studyCohort studyProlonged antibiotic durationObservational studyStudy of patientsAntimicrobial stewardship effortsAntibiotic durationAntibiotic therapyStewardship effortsPneumoniaCancerOddsReadmissionAdultsCohort
2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2022
National Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship
Datta R, Fried T, O’Leary J, Zullo AR, Allore H, Han L, Juthani-Mehta M, Cohen A. National Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship. Open Forum Infectious Diseases 2022, 9: ofac453. PMID: 36147594, PMCID: PMC9487603, DOI: 10.1093/ofid/ofac453.Peer-Reviewed Original ResearchHome-based primary careDays of therapyAntibiotic use ratesAntibiotic useHomebound personsOverall median lengthPhysician home visitsNational cohort studyAntibiotic prescribing trendsVeterans Health AdministrationUse ratesProvider visitsAntibiotic prescriptionsCohort studyPrescribing trendsTelephone visitsMedian agePrescription fillsMedian lengthAntibiotic stewardshipNational cohortPrimary careHome visitsHealth AdministrationPrescribed class
2016
Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit
Rowe T, Araujo KL, Van Ness PH, Pisani MA, Juthani-Mehta M. Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit. Open Forum Infectious Diseases 2016, 3: ofw010. PMID: 26925430, PMCID: PMC4766385, DOI: 10.1093/ofid/ofw010.Peer-Reviewed Original ResearchAssociation of sepsisICU admissionOlder adultsBaseline characteristicsSystemic inflammatory response syndrome criteriaIntensive care unit admissionCox proportional hazards modelImpact of sepsisCare unit admissionProspective cohort studyDiagnosis of sepsisDefinition of sepsisIntensive care unitMain outcome measuresProportional hazards modelUnit admissionSyndrome criteriaCohort studyCare unitOutcome measuresSepsisHazards modelAdmissionMortalityEarly use
2015
Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia
Barakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia. HIV Medicine 2015, 16: 421-430. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaVeterans Aging Cohort StudyVACS IndexCAP outcomesAntiretroviral therapyOlder adultsHigher VACS indexDays of dischargeAging Cohort StudyUninfected participantsCohort studyMean LOSHIV infectionLonger LOSClinical outcomesUnadjusted analysesUninfected groupMultivariable modelEligibility criteriaHIVMale veteransMortality rateART useMortalityOutcomes
2013
Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study
Juthani‐Mehta M, De Rekeneire N, Allore H, Chen S, O'Leary JR, Bauer DC, Harris TB, Newman AB, Yende S, Weyant RJ, Kritchevsky S, Quagliarello V, Study F. Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study. Journal Of The American Geriatrics Society 2013, 61: 1111-1118. PMID: 23772872, PMCID: PMC3714374, DOI: 10.1111/jgs.12325.Peer-Reviewed Original ResearchConceptsModifiable risk factorsIncident mobility limitationCommunity-dwelling older adultsBody Composition StudyRisk factorsPlaque scoresMobility limitationsOlder adultsNovel modifiable risk factorsProspective observational cohort studyObservational cohort studyNonmodifiable risk factorsCases of pneumoniaHistory of pneumoniaCommunity-dwelling adultsAverage attributable fractionMonths of baselineCohort studyExpiratory volumePneumonia preventionDental examinationPrimary outcomeOral hygieneMale sexAttributable fraction
2009
Clinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study
Juthani‐Mehta M, Quagliarello V, Perrelli E, Towle V, Van Ness PH, Tinetti M. Clinical Features to Identify Urinary Tract Infection in Nursing Home Residents: A Cohort Study. Journal Of The American Geriatrics Society 2009, 57: 963-970. PMID: 19490243, PMCID: PMC2692075, DOI: 10.1111/j.1532-5415.2009.02227.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsClinical featuresHome residentsCohort studyTract infectionsMental statusPresence of dysuriaObservational cohort studyArea nursing homesUrine culturePyuriaClinical definitionBacteriuriaHigh riskLower riskDiagnostic uncertaintyNursing homesCombined outcomeDysuriaInfectionUrineOutcomesEpisodesRisk
2007
Diagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*
Juthani‐Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Diagnostic Accuracy of Criteria for Urinary Tract Infection in a Cohort of Nursing Home Residents*. Journal Of The American Geriatrics Society 2007, 55: 1072-1077. PMID: 17608881, DOI: 10.1111/j.1532-5415.2007.01217.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionNursing home residentsNegative predictive valuePositive predictive valueConsensus-based criteriaLaboratory evidenceHome residentsTract infectionsPredictive valueEvidence-based clinical criteriaDiagnostic accuracyProspective cohort studySimilar test characteristicsMcGeer criteriaUTI criteriaCohort studyProspective surveillanceUrine cultureClinical criteriaNursing homesTest characteristicsInfectionLoeb criteriaParticipantsSpecificity