2023
HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy
Chen M, Menon M, Wang W, Fu J, Yi Z, Sun Z, Liu J, Li Z, Mou L, Banu K, Lee S, Dai Y, Anandakrishnan N, Azeloglu E, Lee K, Zhang W, Das B, He J, Wei C. HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy. Nature Communications 2023, 14: 4297. PMID: 37463911, PMCID: PMC10354075, DOI: 10.1038/s41467-023-40086-3.Peer-Reviewed Original ResearchConceptsChronic kidney diseasePro-inflammatory polarizationBone marrow-derived macrophagesRenal inflammationKidney fibrosisMacrophage activationHematopoietic cell kinaseMacrophage pro-inflammatory activityProgressive chronic kidney diseaseIschemia-reperfusion injury modelUnilateral ureteral obstruction kidneysChronic allograft injuryReperfusion injury modelPro-inflammatory activityPro-inflammatory macrophagesHck inhibitorsMarrow-derived macrophagesSuppression of autophagyAllograft injuryUUO miceRenal fibrosisKidney diseaseDiseased kidneysMacrophage numbersInjury model
2020
A POINT MUTATION OF SHROOM3 PROMOTES CD206+ MACROPHAGE INFILTRATION AND KIDNEY FIBROSIS AFTER ISCHEMIA-REPERFUSION INJURY
Tang T, Lu B, Rogers N, Zheng G, Nicholson L, Cao Q, Menon M, Murphy B, Alexander S, Hu M, O’connell P. A POINT MUTATION OF SHROOM3 PROMOTES CD206+ MACROPHAGE INFILTRATION AND KIDNEY FIBROSIS AFTER ISCHEMIA-REPERFUSION INJURY. Transplantation 2020, 104: s166-s167. DOI: 10.1097/01.tp.0000699188.09671.c3.Peer-Reviewed Original Research