2024
Advancing mouse models for transplantation research
Cravedi P, Riella L, Ford M, Valujskikh A, Menon M, Kirk A, Alegre M, Alessandrini A, Feng S, Kehn P, Najafian N, Hancock W, Heeger P, Maltzman J, Mannon R, Nadig S, Odim J, Turnquist H, Shaw J, West L, Luo X, Chong A, Bromberg J, group A. Advancing mouse models for transplantation research. American Journal Of Transplantation 2024, 24: 1362-1368. PMID: 38219866, PMCID: PMC11239793, DOI: 10.1016/j.ajt.2024.01.006.Peer-Reviewed Original ResearchMouse modelMechanisms of transplant rejectionTranslation to clinical trialsFood and Drug Administration-approved drugsMouse transplantation modelEffective clinical therapiesAdvanced mouse modelsTranslation of experimental findingsClinical outcomesTransplantation modelTransplant rejectionClinical trialsMouse studiesClinical therapyTransplantationClinical researchPhysician-scientistsGenetic variabilityTherapyStatistical power analysis
2023
Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival
Sun Z, Zhang Z, Banu K, Gibson I, Colvin R, Yi Z, Zhang W, De Kumar B, Reghuvaran A, Pell J, Manes T, Djamali A, Gallon L, O'Connell P, He J, Pober J, Heeger P, Menon M. Multiscale genetic architecture of donor-recipient differences reveals intronic LIMS1 mismatches associated with kidney transplant survival. Journal Of Clinical Investigation 2023, 133: e170420. PMID: 37676733, PMCID: PMC10617779, DOI: 10.1172/jci170420.Peer-Reviewed Original ResearchConceptsDeath-censored graft lossHuman leukocyte antigenExpression quantitative trait lociT cellsTGF-β1TGF-β1/Smad pathwayDonor-recipient differencesKidney allograft lossChronic allograft rejectionKidney transplant survivalDonor-recipient mismatchActive TGF-β1Allograft lossGraft lossAllograft rejectionTransplant cohortPeripheral bloodLeukocyte antigenClinical trialsImmune cellsHaplotype mismatchGenome-wide scaleTransplant survivalQuantitative trait lociSingle nucleotide polymorphism data
2021
Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes
Zhang Z, Sun Z, Fu J, Lin Q, Banu K, Chauhan K, Planoutene M, Wei C, Salem F, Yi Z, Liu R, Cravedi P, Cheng H, Hao K, O’Connell P, Ishibe S, Zhang W, Coca SG, Gibson IW, Colvin RB, He J, Heeger PS, Murphy B, Menon MC. Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes. Journal Of Clinical Investigation 2021, 131 PMID: 34499625, PMCID: PMC8592534, DOI: 10.1172/jci146643.Peer-Reviewed Original ResearchConceptsDeath-censored allograft lossAPOL1 risk allelesRisk allelesTransplant outcomesDeath-censored renal allograft survivalRenal allograft survivalChronic allograft rejectionKidney transplant waitlistKidney transplant cohortRisk allele carriersAllograft lossAllograft survivalGraft lossRejection episodesTransplant cohortAllograft rejectionDonor kidneysNative kidneysNK cellsImmunomodulatory roleTransplant waitlistAPOL1 genotypeClinical trialsHealthy controlsHispanic recipients